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Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Zamora-Ros, Raul ; Barupal, Dinesh Kumar ; Rothwell, Joseph A. ; Jenab, Mazda ; Fedirko, Veronika ; Romieu, Isabelle ; Aleksandrova, Krasimira ; Overvad, Kim ; Kyrø, Cecilie and Tjønneland, Anne , et al. (2017) In International Journal of Cancer 140(8). p.1836-1844
Abstract

Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition... (More)

Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93–1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
colorectal cancer, diet, EPIC, flavonoids, prospective cohort
in
International Journal of Cancer
volume
140
issue
8
pages
9 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:28006847
  • wos:000395181800014
  • scopus:85010629654
ISSN
0020-7136
DOI
10.1002/ijc.30582
language
English
LU publication?
yes
id
6bc07e55-ed64-489e-8022-031a9e0b5d50
date added to LUP
2017-03-13 07:56:18
date last changed
2024-07-21 17:19:15
@article{6bc07e55-ed64-489e-8022-031a9e0b5d50,
  abstract     = {{<p>Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93–1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.</p>}},
  author       = {{Zamora-Ros, Raul and Barupal, Dinesh Kumar and Rothwell, Joseph A. and Jenab, Mazda and Fedirko, Veronika and Romieu, Isabelle and Aleksandrova, Krasimira and Overvad, Kim and Kyrø, Cecilie and Tjønneland, Anne and Affret, Aurélie and His, Mathilde and Boutron-Ruault, Marie-Christine and Katzke, Verena and Kühn, Tilman and Boeing, Heiner and Trichopoulou, Antonia and Naska, Androniki and Kritikou, Maria and Saieva, Calogero and Agnoli, Claudia and Santucci de Magistris, Maria and Tumino, Rosario and Fasanelli, Francesca and Weiderpass, Elisabete and Skeie, Guri and Merino, Susana and Jakszyn, Paula and Sánchez, Maria-José and Dorronsoro, Miren and Navarro, Carmen and Ardanaz, Eva and Sonestedt, Emily and Ericson, Ulrika and Maria Nilsson, Lena and Bodén, Stina and Bueno-De-Mesquita, Bas H. and Peeters, Petra H. and Perez-Cornago, Aurora and Wareham, Nicholas J and Khaw, Kay-Thee and Freisling, Heinz and Cross, Amanda J and Riboli, Elio and Scalbert, Augustin}},
  issn         = {{0020-7136}},
  keywords     = {{colorectal cancer; diet; EPIC; flavonoids; prospective cohort}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{8}},
  pages        = {{1836--1844}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort}},
  url          = {{http://dx.doi.org/10.1002/ijc.30582}},
  doi          = {{10.1002/ijc.30582}},
  volume       = {{140}},
  year         = {{2017}},
}