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Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

Kliemann, Nathalie ; Murphy, Neil ; Viallon, Vivian ; Freisling, Heinz ; Tsilidis, Konstantinos K. ; Rinaldi, Sabina ; Mancini, Francesca R. ; Fagherazzi, Guy ; Boutron-Ruault, Marie Christine and Boeing, Heiner , et al. (2020) In International Journal of Cancer 147(3). p.648-661
Abstract

Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of... (More)

Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
basal metabolic rate, cancer, metabolic disorder, obesity
in
International Journal of Cancer
volume
147
issue
3
pages
14 pages
publisher
John Wiley and Sons
external identifiers
  • scopus:85075421128
  • pmid:31652358
ISSN
0020-7136
DOI
10.1002/ijc.32753
language
English
LU publication?
yes
id
6fb13269-15f5-4342-99e9-6d48aeacf174
date added to LUP
2019-12-12 09:54:43
date last changed
2021-06-13 06:50:09
@article{6fb13269-15f5-4342-99e9-6d48aeacf174,
  abstract     = {<p>Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR<sub>1-SD</sub>]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR<sub>1-SD</sub>: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR<sub>1-SD</sub>: 1.16; 95% CI 1.01; 1.35), pancreatic (HR<sub>1-SD</sub>: 1.37; 95% CI 1.13; 1.66), thyroid (HR<sub>1-SD</sub>: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR<sub>1-SD</sub>: 1.17; 95% CI 1.11; 1.22) and endometrial (HR<sub>1-SD</sub>: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.</p>},
  author       = {Kliemann, Nathalie and Murphy, Neil and Viallon, Vivian and Freisling, Heinz and Tsilidis, Konstantinos K. and Rinaldi, Sabina and Mancini, Francesca R. and Fagherazzi, Guy and Boutron-Ruault, Marie Christine and Boeing, Heiner and Schulze, Matthias B. and Masala, Giovanna and Krogh, Vittorio and Sacerdote, Carlotta and de Magistris, Maria S. and Bueno-de-Mesquita, Bas and Weiderpass, Elisabete and Kühn, Tilman and Kaaks, Rudolf and Jakszyn, Paula and Redondo-Sánchez, Daniel and Amiano, Pilar and Chirlaque, Maria Dolores and Gurrea, Aurelio B. and Ericson, Ulrica and Drake, Isabel and Nøst, Therese H. and Aune, Dagfinn and May, Anne M. and Tjønneland, Anne and Dahm, Christina C. and Overvad, Kim and Tumino, Rosario and Quirós, Jose R. and Trichopoulou, Antonia and Karakatsani, Anna and La Vecchia, Carlo and Nilsson, Lena M. and Riboli, Elio and Huybrechts, Inge and Gunter, Marc J.},
  issn         = {0020-7136},
  language     = {eng},
  month        = {08},
  number       = {3},
  pages        = {648--661},
  publisher    = {John Wiley and Sons},
  series       = {International Journal of Cancer},
  title        = {Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.32753},
  doi          = {10.1002/ijc.32753},
  volume       = {147},
  year         = {2020},
}