Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition
(2020) In International Journal of Cancer 147(3). p.648-661- Abstract
Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of... (More)
Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.
(Less)
- author
- organization
- publishing date
- 2020-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- basal metabolic rate, cancer, metabolic disorder, obesity
- in
- International Journal of Cancer
- volume
- 147
- issue
- 3
- pages
- 14 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:31652358
- scopus:85075421128
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.32753
- language
- English
- LU publication?
- yes
- id
- 6fb13269-15f5-4342-99e9-6d48aeacf174
- date added to LUP
- 2019-12-12 09:54:43
- date last changed
- 2024-04-17 01:10:19
@article{6fb13269-15f5-4342-99e9-6d48aeacf174,
abstract = {{<p>Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR<sub>1-SD</sub>]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR<sub>1-SD</sub>: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR<sub>1-SD</sub>: 1.16; 95% CI 1.01; 1.35), pancreatic (HR<sub>1-SD</sub>: 1.37; 95% CI 1.13; 1.66), thyroid (HR<sub>1-SD</sub>: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR<sub>1-SD</sub>: 1.17; 95% CI 1.11; 1.22) and endometrial (HR<sub>1-SD</sub>: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.</p>}},
author = {{Kliemann, Nathalie and Murphy, Neil and Viallon, Vivian and Freisling, Heinz and Tsilidis, Konstantinos K. and Rinaldi, Sabina and Mancini, Francesca R. and Fagherazzi, Guy and Boutron-Ruault, Marie Christine and Boeing, Heiner and Schulze, Matthias B. and Masala, Giovanna and Krogh, Vittorio and Sacerdote, Carlotta and de Magistris, Maria S. and Bueno-de-Mesquita, Bas and Weiderpass, Elisabete and Kühn, Tilman and Kaaks, Rudolf and Jakszyn, Paula and Redondo-Sánchez, Daniel and Amiano, Pilar and Chirlaque, Maria Dolores and Gurrea, Aurelio B. and Ericson, Ulrica and Drake, Isabel and Nøst, Therese H. and Aune, Dagfinn and May, Anne M. and Tjønneland, Anne and Dahm, Christina C. and Overvad, Kim and Tumino, Rosario and Quirós, Jose R. and Trichopoulou, Antonia and Karakatsani, Anna and La Vecchia, Carlo and Nilsson, Lena M. and Riboli, Elio and Huybrechts, Inge and Gunter, Marc J.}},
issn = {{0020-7136}},
keywords = {{basal metabolic rate; cancer; metabolic disorder; obesity}},
language = {{eng}},
month = {{08}},
number = {{3}},
pages = {{648--661}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition}},
url = {{http://dx.doi.org/10.1002/ijc.32753}},
doi = {{10.1002/ijc.32753}},
volume = {{147}},
year = {{2020}},
}