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Pharmacological up-regulation of heart rate in ex vivo heart evaluation

Steen, Erik LU orcid ; Soltesz, Kristian LU orcid ; Li, Mei LU orcid ; Pigot, Henry LU orcid ; Paskevicius, Audrius LU ; Liao, Qiuming LU and Steen, Stig LU (2026) 10th IEEE Conference on Control Technology and Applications, CCTA 2026
Abstract
In this paper, we present the development of a closed-loop drug delivery system for heart rate up-regulation in a novel ex vivo setup for functional evaluation of donor hearts. Such up-regulation is required to enable physiological testing aimed at supporting transplant decision-making. Clinical constraints prioritize safety over setpoint tracking performance. Accordingly, we develop a minimal dynamical model capturing the relevant response characteristics and use it to derive a closed-form upper bound on overshoot and tune a simple integrate-reset controller. We describe the real-time control system, which estimates heart rate from blood pressure measurements and regulates adrenaline infusion via a clinically certified pump. The... (More)
In this paper, we present the development of a closed-loop drug delivery system for heart rate up-regulation in a novel ex vivo setup for functional evaluation of donor hearts. Such up-regulation is required to enable physiological testing aimed at supporting transplant decision-making. Clinical constraints prioritize safety over setpoint tracking performance. Accordingly, we develop a minimal dynamical model capturing the relevant response characteristics and use it to derive a closed-form upper bound on overshoot and tune a simple integrate-reset controller. We describe the real-time control system, which estimates heart rate from blood pressure measurements and regulates adrenaline infusion via a clinically certified pump. The controller design and modeling framework are discussed. Finally, the system is demonstrated in three ex vivo experiments on porcine hearts, showing closed-loop performance comparable to carefully executed manual drug titration. The controller is now used routinely in our ongoing evaluations. (Less)
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author
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Proceedings of the 10th IEEE Coinference on Control Technology and Applications (CCTA) 2026
publisher
IEEE Press
conference name
10th IEEE Conference on Control Technology and Applications, CCTA 2026
conference location
Vancouver, Canada
conference dates
2026-08-12 - 2026-08-14
ISBN
979-8-3195-3146-9
DOI
10.1109/CCTA62090.2026.11684254
project
Functional ex vivo heart evaluation
language
English
LU publication?
yes
id
71843ef2-5a3d-4bbe-8ff5-9e058f05524e
date added to LUP
2026-05-08 10:37:28
date last changed
2026-09-17 15:59:43
@inproceedings{71843ef2-5a3d-4bbe-8ff5-9e058f05524e,
  abstract     = {{In this paper, we present the development of a closed-loop drug delivery system for heart rate up-regulation in a novel ex vivo setup for functional evaluation of donor hearts. Such up-regulation is required to enable physiological testing aimed at supporting transplant decision-making. Clinical constraints prioritize safety over setpoint tracking performance. Accordingly, we develop a minimal dynamical model capturing the relevant response characteristics and use it to derive a closed-form upper bound on overshoot and tune a simple integrate-reset controller. We describe the real-time control system, which estimates heart rate from blood pressure measurements and regulates adrenaline infusion via a clinically certified pump. The controller design and modeling framework are discussed. Finally, the system is demonstrated in three ex vivo experiments on porcine hearts, showing closed-loop performance comparable to carefully executed manual drug titration. The controller is now used routinely in our ongoing evaluations.}},
  author       = {{Steen, Erik and Soltesz, Kristian and Li, Mei and Pigot, Henry and Paskevicius, Audrius and Liao, Qiuming and Steen, Stig}},
  booktitle    = {{Proceedings of the 10th IEEE Coinference on Control Technology and Applications (CCTA) 2026}},
  isbn         = {{979-8-3195-3146-9}},
  language     = {{eng}},
  publisher    = {{IEEE Press}},
  title        = {{Pharmacological up-regulation of heart rate in ex vivo heart evaluation}},
  url          = {{https://lup.lub.lu.se/search/files/252611396/HR_CCTA_2026-final.pdf}},
  doi          = {{10.1109/CCTA62090.2026.11684254}},
  year         = {{2026}},
}