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Intra-Patient Evolution of HIV-2 Molecular Properties

Palm, Angelica A. LU ; Esbjörnsson, Joakim LU orcid ; Kvist, Anders LU ; Månsson, Fredrik LU ; Biague, Antonio ; Norrgren, Hans LU ; Jansson, Marianne LU and Medstrand, Patrik LU orcid (2022) In Viruses 14(11).
Abstract

Limited data are available on the pathogenesis of HIV-2, and the evolution of Env molecular properties during disease progression is not fully elucidated. We investigated the intra-patient evolution of molecular properties of HIV-2 Env regions (V1–C3) during the asymptomatic, treatment-naïve phase of the infection in 16 study participants, stratified into faster or slower progressors. Most notably, the rate of change in the number of potential N-linked glycosylation sites (PNGS) within the Env (V1–C3) regions differed between progressor groups. With declining CD4+ T-cell levels, slower progressors showed, on average, a decrease in the number of PNGSs, while faster progressors showed no significant change. Furthermore,... (More)

Limited data are available on the pathogenesis of HIV-2, and the evolution of Env molecular properties during disease progression is not fully elucidated. We investigated the intra-patient evolution of molecular properties of HIV-2 Env regions (V1–C3) during the asymptomatic, treatment-naïve phase of the infection in 16 study participants, stratified into faster or slower progressors. Most notably, the rate of change in the number of potential N-linked glycosylation sites (PNGS) within the Env (V1–C3) regions differed between progressor groups. With declining CD4+ T-cell levels, slower progressors showed, on average, a decrease in the number of PNGSs, while faster progressors showed no significant change. Furthermore, diversity increased significantly with time in faster progressors, whereas no such change was observed in slower progressors. No differences were identified between the progressor groups in the evolution of length or charge of the analyzed Env regions. Predicted virus CXCR4 use was rare and did not emerge as a dominating viral population during the studied disease course (median 7.9 years, interquartile range [IQR]: 5.2–14.0) in either progressor groups. Further work building on our observations may explain molecular hallmarks of HIV-2 disease progression and differences in pathogenesis between HIV-1 and HIV-2.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coreceptor, disease progression, evolution, HIV-1, HIV-2, molecular properties, PNGS
in
Viruses
volume
14
issue
11
article number
2447
publisher
MDPI AG
external identifiers
  • pmid:36366545
  • scopus:85141797574
ISSN
1999-4915
DOI
10.3390/v14112447
language
English
LU publication?
yes
id
7358dde3-b2ff-4e07-b6dd-730b526dd351
date added to LUP
2022-11-30 08:46:55
date last changed
2024-05-28 17:49:59
@article{7358dde3-b2ff-4e07-b6dd-730b526dd351,
  abstract     = {{<p>Limited data are available on the pathogenesis of HIV-2, and the evolution of Env molecular properties during disease progression is not fully elucidated. We investigated the intra-patient evolution of molecular properties of HIV-2 Env regions (V1–C3) during the asymptomatic, treatment-naïve phase of the infection in 16 study participants, stratified into faster or slower progressors. Most notably, the rate of change in the number of potential N-linked glycosylation sites (PNGS) within the Env (V1–C3) regions differed between progressor groups. With declining CD4<sup>+</sup> T-cell levels, slower progressors showed, on average, a decrease in the number of PNGSs, while faster progressors showed no significant change. Furthermore, diversity increased significantly with time in faster progressors, whereas no such change was observed in slower progressors. No differences were identified between the progressor groups in the evolution of length or charge of the analyzed Env regions. Predicted virus CXCR4 use was rare and did not emerge as a dominating viral population during the studied disease course (median 7.9 years, interquartile range [IQR]: 5.2–14.0) in either progressor groups. Further work building on our observations may explain molecular hallmarks of HIV-2 disease progression and differences in pathogenesis between HIV-1 and HIV-2.</p>}},
  author       = {{Palm, Angelica A. and Esbjörnsson, Joakim and Kvist, Anders and Månsson, Fredrik and Biague, Antonio and Norrgren, Hans and Jansson, Marianne and Medstrand, Patrik}},
  issn         = {{1999-4915}},
  keywords     = {{coreceptor; disease progression; evolution; HIV-1; HIV-2; molecular properties; PNGS}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{MDPI AG}},
  series       = {{Viruses}},
  title        = {{Intra-Patient Evolution of HIV-2 Molecular Properties}},
  url          = {{http://dx.doi.org/10.3390/v14112447}},
  doi          = {{10.3390/v14112447}},
  volume       = {{14}},
  year         = {{2022}},
}