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Dietary Fat, Fat Subtypes and Hepatocellular Carcinoma in a Large European Cohort.

Duarte-Salles, Talita; Fedirko, Veronika; Stepien, Magdalena; Aleksandrova, Krasimira; Bamia, Christina; Lagiou, Pagona; Laursen, Anne Sofie Dam; Hansen, Louise; Overvad, Kim and Tjønneland, Anne, et al. (2015) In International Journal of Cancer 137(11). p.2715-2728
Abstract
The role of amount and type of dietary fat consumption in the aetiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95%CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and... (More)
The role of amount and type of dietary fat consumption in the aetiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95%CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC=122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/d, HR=0.80, 95%CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/d, HR=0.71, 95%CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/d, HR=0.92, 95%CI: 0.68-1.25). There was no association between saturated fats (HR=1.08, 95%CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR=0.86, 95%CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk. This article is protected by copyright. All rights reserved. (Less)
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International Journal of Cancer
volume
137
issue
11
pages
2715 - 2728
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John Wiley & Sons
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  • pmid:26081477
  • wos:000362843000017
  • scopus:84941746153
ISSN
0020-7136
DOI
10.1002/ijc.29643
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English
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yes
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http://www.ncbi.nlm.nih.gov/pubmed/26081477?dopt=Abstract
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2015-07-08 18:36:28
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@article{7d2be5ab-18f0-44d3-b66e-d722a6a7ead4,
  abstract     = {The role of amount and type of dietary fat consumption in the aetiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95%CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC=122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/d, HR=0.80, 95%CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/d, HR=0.71, 95%CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/d, HR=0.92, 95%CI: 0.68-1.25). There was no association between saturated fats (HR=1.08, 95%CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR=0.86, 95%CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk. This article is protected by copyright. All rights reserved.},
  author       = {Duarte-Salles, Talita and Fedirko, Veronika and Stepien, Magdalena and Aleksandrova, Krasimira and Bamia, Christina and Lagiou, Pagona and Laursen, Anne Sofie Dam and Hansen, Louise and Overvad, Kim and Tjønneland, Anne and Boutron-Ruault, Marie-Christine and Fagherazzi, Guy and His, Mathilde and Boeing, Heiner and Katzke, Verena and Kühn, Tilman and Trichopoulou, Antonia and Valanou, Elissavet and Kritikou, Maria and Masala, Giovanna and Panico, Salvatore and Sieri, Sabina and Ricceri, Fulvio and Tumino, Rosario and Bueno-de-Mesquita, H Bas and Peeters, Petra H and Hjartåker, Anette and Skeie, Guri and Weiderpass, Elisabete and Ardanaz, Eva and Bonet, Catalina and Chirlaque, Maria-Dolores and Dorronsoro, Miren and Quirós, J Ramón and Johansson, Ingegerd and Ohlsson, Bodil and Sjöberg, Klas and Wennberg, Maria and Khaw, Kay-Tee and Travis, Ruth C and Wareham, Nick and Ferrari, Pietro and Freisling, Heinz and Romieu, Isabelle and Cross, Amanda J and Gunter, Marc and Lu, Yunxia and Jenab, Mazda},
  issn         = {0020-7136},
  language     = {eng},
  number       = {11},
  pages        = {2715--2728},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Dietary Fat, Fat Subtypes and Hepatocellular Carcinoma in a Large European Cohort.},
  url          = {http://dx.doi.org/10.1002/ijc.29643},
  volume       = {137},
  year         = {2015},
}