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Biological determinants of bladder cancer gene expression subtypes.

Aine, Mattias LU ; Eriksson, Pontus LU ; Liedberg, Fredrik LU ; Sjödahl, Gottfrid LU and Höglund, Mattias LU (2015) In Scientific Reports 5.
Abstract
Molecular stratification of tumors by gene expression profiling has been applied to a large number of human malignancies and holds great promise for personalized treatment. Comprehensive classification schemes for urothelial carcinoma have been proposed by three separate groups but have not previously been evaluated simultaneously in independent data. Here we map the interrelations between the proposed molecular subtypes onto the intrinsic structure of a rich independent dataset and show that subtype stratification within each scheme can be explained in terms of a set of common underlying biological processes. We highlight novel biological and genomic drivers of urothelial carcinoma molecular subtypes and show that tumors carrying genomic... (More)
Molecular stratification of tumors by gene expression profiling has been applied to a large number of human malignancies and holds great promise for personalized treatment. Comprehensive classification schemes for urothelial carcinoma have been proposed by three separate groups but have not previously been evaluated simultaneously in independent data. Here we map the interrelations between the proposed molecular subtypes onto the intrinsic structure of a rich independent dataset and show that subtype stratification within each scheme can be explained in terms of a set of common underlying biological processes. We highlight novel biological and genomic drivers of urothelial carcinoma molecular subtypes and show that tumors carrying genomic aberrations characteristic of distinct molecular pathways converge on a common top level phenotype corresponding to the two major molecular subtypes of non-muscle invasive disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
5
publisher
Nature Publishing Group
external identifiers
  • pmid:26051783
  • wos:000356067600001
  • scopus:84930959056
ISSN
2045-2322
DOI
10.1038/srep10957
language
English
LU publication?
yes
id
007d7aa8-56bd-4439-8ad3-b28f8ec3ab6b (old id 7487640)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26051783?dopt=Abstract
date added to LUP
2015-07-07 16:47:59
date last changed
2017-11-05 03:58:11
@article{007d7aa8-56bd-4439-8ad3-b28f8ec3ab6b,
  abstract     = {Molecular stratification of tumors by gene expression profiling has been applied to a large number of human malignancies and holds great promise for personalized treatment. Comprehensive classification schemes for urothelial carcinoma have been proposed by three separate groups but have not previously been evaluated simultaneously in independent data. Here we map the interrelations between the proposed molecular subtypes onto the intrinsic structure of a rich independent dataset and show that subtype stratification within each scheme can be explained in terms of a set of common underlying biological processes. We highlight novel biological and genomic drivers of urothelial carcinoma molecular subtypes and show that tumors carrying genomic aberrations characteristic of distinct molecular pathways converge on a common top level phenotype corresponding to the two major molecular subtypes of non-muscle invasive disease.},
  articleno    = {10957},
  author       = {Aine, Mattias and Eriksson, Pontus and Liedberg, Fredrik and Sjödahl, Gottfrid and Höglund, Mattias},
  issn         = {2045-2322},
  language     = {eng},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Biological determinants of bladder cancer gene expression subtypes.},
  url          = {http://dx.doi.org/10.1038/srep10957},
  volume       = {5},
  year         = {2015},
}