Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Heath, Alicia K. ; Muller, David C. ; van den Brandt, Piet A. ; Papadimitriou, Nikos ; Critselis, Elena ; Gunter, Marc ; Vineis, Paolo ; Weiderpass, Elisabete ; Fagherazzi, Guy and Boeing, Heiner , et al. (2020) In Breast cancer research : BCR 22(1).
Abstract

BACKGROUND: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. METHODS: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients... (More)

BACKGROUND: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. METHODS: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). RESULTS: Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. CONCLUSIONS: Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alcohol, Breast cancer, Diet, Fibre, Foods, Nutrients
in
Breast cancer research : BCR
volume
22
issue
1
article number
5
publisher
BioMed Central (BMC)
external identifiers
  • pmid:31931881
  • scopus:85077786013
ISSN
1465-5411
DOI
10.1186/s13058-019-1244-7
language
English
LU publication?
yes
id
75174e86-e7ae-455c-8737-cb303a8570b9
date added to LUP
2020-01-27 09:18:12
date last changed
2024-02-16 09:34:38
@article{75174e86-e7ae-455c-8737-cb303a8570b9,
  abstract     = {{<p>BACKGROUND: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. METHODS: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). RESULTS: Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03-1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03-1.06 and 1.04, 95% CI 1.02-1.06, respectively), whereas higher intakes of fibre, apple/pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94-0.98; 0.96, 95% CI 0.94-0.99; and 0.96, 95% CI 0.95-0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. CONCLUSIONS: Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk.</p>}},
  author       = {{Heath, Alicia K. and Muller, David C. and van den Brandt, Piet A. and Papadimitriou, Nikos and Critselis, Elena and Gunter, Marc and Vineis, Paolo and Weiderpass, Elisabete and Fagherazzi, Guy and Boeing, Heiner and Ferrari, Pietro and Olsen, Anja and Tjønneland, Anne and Arveux, Patrick and Boutron-Ruault, Marie Christine and Mancini, Francesca Romana and Kühn, Tilman and Turzanski-Fortner, Renée and Schulze, Matthias B. and Karakatsani, Anna and Thriskos, Paschalis and Trichopoulou, Antonia and Masala, Giovanna and Contiero, Paolo and Ricceri, Fulvio and Panico, Salvatore and Bueno-de-Mesquita, Bas and Bakker, Marije F. and van Gils, Carla H. and Olsen, Karina Standahl and Skeie, Guri and Lasheras, Cristina and Agudo, Antonio and Rodríguez-Barranco, Miguel and Sánchez, Maria José and Amiano, Pilar and Chirlaque, María Dolores and Barricarte, Aurelio and Drake, Isabel and Ericson, Ulrika and Johansson, Ingegerd and Winkvist, Anna and Key, Tim and Freisling, Heinz and His, Mathilde and Huybrechts, Inge and Christakoudi, Sofia and Ellingjord-Dale, Merete and Riboli, Elio and Tsilidis, Konstantinos K. and Tzoulaki, Ioanna}},
  issn         = {{1465-5411}},
  keywords     = {{Alcohol; Breast cancer; Diet; Fibre; Foods; Nutrients}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Breast cancer research : BCR}},
  title        = {{Nutrient-wide association study of 92 foods and nutrients and breast cancer risk}},
  url          = {{http://dx.doi.org/10.1186/s13058-019-1244-7}},
  doi          = {{10.1186/s13058-019-1244-7}},
  volume       = {{22}},
  year         = {{2020}},
}