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BDNF makes cultured dentate granule cells more resistant to hypoglycaemic damage

Kokaia, Z LU ; Othberg, A LU ; Kokaia, M LU and Lindvall, O LU (1994) In NeuroReport 5(10). p.4-1241
Abstract

The aim of this study was to explore whether brain-derived neurotrophic factor (BDNF) can improve neuronal survival in cell cultures of rat dentate gyrus subjected to a hypoglycaemic insult. Glucose deprivation for 15 h caused severe neuronal loss (about 70%). BDNF added either 24 h before or 4 h after onset of hypoglycaemia completely protected granule cells against this insult-induced damage. Nerve growth factor (NGF) had similar effects. These findings support the hypothesis that the rapid upregulation of BDNF mRNA in dentate granule cells after brief periods of hypoglycaemic coma and other insults is a local protective mechanism.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Brain-Derived Neurotrophic Factor, Cell Survival, Cells, Cultured, Culture Media, Glucose, Hippocampus, Hypoglycemia, Immunohistochemistry, Nerve Growth Factors, Nerve Tissue Proteins, Neurons, Rats, Rats, Sprague-Dawley, Journal Article, Research Support, Non-U.S. Gov't
in
NeuroReport
volume
5
issue
10
pages
4 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • Scopus:0028206375
ISSN
0959-4965
language
English
LU publication?
yes
id
7803633f-2260-4e52-9c39-23c5ea02f961
date added to LUP
2016-12-11 10:08:05
date last changed
2017-01-01 08:42:56
@article{7803633f-2260-4e52-9c39-23c5ea02f961,
  abstract     = {<p>The aim of this study was to explore whether brain-derived neurotrophic factor (BDNF) can improve neuronal survival in cell cultures of rat dentate gyrus subjected to a hypoglycaemic insult. Glucose deprivation for 15 h caused severe neuronal loss (about 70%). BDNF added either 24 h before or 4 h after onset of hypoglycaemia completely protected granule cells against this insult-induced damage. Nerve growth factor (NGF) had similar effects. These findings support the hypothesis that the rapid upregulation of BDNF mRNA in dentate granule cells after brief periods of hypoglycaemic coma and other insults is a local protective mechanism.</p>},
  author       = {Kokaia, Z and Othberg, A and Kokaia, M and Lindvall, O},
  issn         = {0959-4965},
  keyword      = {Animals,Brain-Derived Neurotrophic Factor,Cell Survival,Cells, Cultured,Culture Media,Glucose,Hippocampus,Hypoglycemia,Immunohistochemistry,Nerve Growth Factors,Nerve Tissue Proteins,Neurons,Rats,Rats, Sprague-Dawley,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {06},
  number       = {10},
  pages        = {4--1241},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {BDNF makes cultured dentate granule cells more resistant to hypoglycaemic damage},
  volume       = {5},
  year         = {1994},
}