The EAT-Lancet Diet Index, Plasma Proteins, and Risk of Heart Failure in a Population-Based Cohort
Zhang, Shunming LU ; Marken, Ida ; Stubbendorff, Anna LU
; Ericson, Ulrika
LU
; Qi, Lu
; Sonestedt, Emily
LU
and Borné, Yan
LU
(2024)
In JACC. Heart failure
p.1-12
- Abstract
BACKGROUND: The landmark EAT-Lancet Commission proposed that a planetary health diet is comprised mainly of plant-based foods. However, studies examining whether this diet is associated with heart failure (HF) are currently lacking. In addition, the potential proteomics mechanism on the association between diet and HF warrants further elucidation.
OBJECTIVES: This study aims to both examine the association between the EAT-Lancet diet index and risk of HF and identify plasma proteins underlying such an association.
METHODS: This prospective cohort study included 23,260 participants. HF cases during the follow-up were identified through the Swedish national register. An EAT-Lancet diet index (score range: 0-42) was created to... (More)
BACKGROUND: The landmark EAT-Lancet Commission proposed that a planetary health diet is comprised mainly of plant-based foods. However, studies examining whether this diet is associated with heart failure (HF) are currently lacking. In addition, the potential proteomics mechanism on the association between diet and HF warrants further elucidation.
OBJECTIVES: This study aims to both examine the association between the EAT-Lancet diet index and risk of HF and identify plasma proteins underlying such an association.
METHODS: This prospective cohort study included 23,260 participants. HF cases during the follow-up were identified through the Swedish national register. An EAT-Lancet diet index (score range: 0-42) was created to assess adherence to the EAT-Lancet reference diet. In a subcohort (n = 4,742), fasting plasma proteins were quantified.
RESULTS: During a median follow-up of 25.0 years, 1,768 incident HF cases were documented. After adjusting for sociodemographic, lifestyle, diabetes, hypertension, use of lipid-lowering drugs, and body mass index, the HR per 3-point increase of the EAT-Lancet diet index was 0.93 (95% CI: 0.88-0.97). This association was robust in several sensitivity analyses. Among the included 136 plasma proteins, a total of 8 proteins (AM, GDF15, IL6, TIM, CTSD, CCL20, FS, and FUR) were both inversely associated with the EAT-Lancet diet index and positively associated with risk of HF; the overall proteomic score mediated 9.4% (95% CI: 2.2%-32.1%) of the association.
CONCLUSIONS: Higher adherence to the EAT-Lancet diet was associated with a lower risk of HF. The identified eight plasma proteins provide information on potential pathways mediating such an association.
(Less)
- author
- Zhang, Shunming
LU
; Marken, Ida
; Stubbendorff, Anna
LU
; Ericson, Ulrika
LU
; Qi, Lu
; Sonestedt, Emily
LU
and Borné, Yan
LU
- organization
- publishing date
- 2024-03-22
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- JACC. Heart failure
- pages
- 1 - 12
- publisher
- Elsevier
- external identifiers
-
- pmid:38573265
- ISSN
- 2213-1779
- DOI
- 10.1016/j.jchf.2024.02.017
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
- id
- 7a0bfa77-c5d5-4c18-ac15-e5a8a9d6315a
- date added to LUP
- 2024-04-06 11:42:18
- date last changed
- 2024-04-08 07:20:36
@article{7a0bfa77-c5d5-4c18-ac15-e5a8a9d6315a,
abstract = {{<p>BACKGROUND: The landmark EAT-Lancet Commission proposed that a planetary health diet is comprised mainly of plant-based foods. However, studies examining whether this diet is associated with heart failure (HF) are currently lacking. In addition, the potential proteomics mechanism on the association between diet and HF warrants further elucidation.</p><p>OBJECTIVES: This study aims to both examine the association between the EAT-Lancet diet index and risk of HF and identify plasma proteins underlying such an association.</p><p>METHODS: This prospective cohort study included 23,260 participants. HF cases during the follow-up were identified through the Swedish national register. An EAT-Lancet diet index (score range: 0-42) was created to assess adherence to the EAT-Lancet reference diet. In a subcohort (n = 4,742), fasting plasma proteins were quantified.</p><p>RESULTS: During a median follow-up of 25.0 years, 1,768 incident HF cases were documented. After adjusting for sociodemographic, lifestyle, diabetes, hypertension, use of lipid-lowering drugs, and body mass index, the HR per 3-point increase of the EAT-Lancet diet index was 0.93 (95% CI: 0.88-0.97). This association was robust in several sensitivity analyses. Among the included 136 plasma proteins, a total of 8 proteins (AM, GDF15, IL6, TIM, CTSD, CCL20, FS, and FUR) were both inversely associated with the EAT-Lancet diet index and positively associated with risk of HF; the overall proteomic score mediated 9.4% (95% CI: 2.2%-32.1%) of the association.</p><p>CONCLUSIONS: Higher adherence to the EAT-Lancet diet was associated with a lower risk of HF. The identified eight plasma proteins provide information on potential pathways mediating such an association.</p>}},
author = {{Zhang, Shunming and Marken, Ida and Stubbendorff, Anna and Ericson, Ulrika and Qi, Lu and Sonestedt, Emily and Borné, Yan}},
issn = {{2213-1779}},
language = {{eng}},
month = {{03}},
pages = {{1--12}},
publisher = {{Elsevier}},
series = {{JACC. Heart failure}},
title = {{The EAT-Lancet Diet Index, Plasma Proteins, and Risk of Heart Failure in a Population-Based Cohort}},
url = {{http://dx.doi.org/10.1016/j.jchf.2024.02.017}},
doi = {{10.1016/j.jchf.2024.02.017}},
year = {{2024}},
}