Dietary oat bran reduces systemic inflammation in mice subjected to pelvic irradiation
(2020) In Nutrients 12(8).- Abstract
Patients undergoing radiotherapy to treat pelvic-organ cancer are commonly advised to follow a restricted fiber diet. However, reducing dietary fiber may promote gastrointestinal inflammation, eventually leading to deteriorated intestinal health. The goal of this study was to evaluate the influence of dietary fiber on radiation-induced inflammation. C57BL/6J male mice were fed a High-oat bran diet (15% fiber) or a No-fiber diet (0% fiber) and were either irradiated (32 Gy delivered in four fractions) to the colorectal region or only sedated (controls). The dietary intervention started at 2 weeks before irradiation and lasted for 1, 6, and 18 weeks after irradiation, at which time points mice were sacrificed and their serum samples were... (More)
Patients undergoing radiotherapy to treat pelvic-organ cancer are commonly advised to follow a restricted fiber diet. However, reducing dietary fiber may promote gastrointestinal inflammation, eventually leading to deteriorated intestinal health. The goal of this study was to evaluate the influence of dietary fiber on radiation-induced inflammation. C57BL/6J male mice were fed a High-oat bran diet (15% fiber) or a No-fiber diet (0% fiber) and were either irradiated (32 Gy delivered in four fractions) to the colorectal region or only sedated (controls). The dietary intervention started at 2 weeks before irradiation and lasted for 1, 6, and 18 weeks after irradiation, at which time points mice were sacrificed and their serum samples were assayed for 23 cytokines and chemokines. Our analyses show that irradiation increased the serum cytokine levels at all the time points analyzed. The No-fiber irradiated mice had significantly higher levels of pro-inflammatory cytokines than the High-oat irradiated mice at all time points. The results indicate that a fiber-rich oat bran diet reduces the intensity of radiation-induced inflammation, both at an early and late stage. Based on the results, it seems that the advice to follow a low-fiber diet during radiotherapy may increase the risk of decreased intestinal health in cancer survivors.
(Less)
- author
- Patel, Piyush ; Malipatlolla, Dilip Kumar ; Devarakonda, Sravani ; Bull, Cecilia ; Rascón, Ana LU ; Nyman, Margareta LU ; Stringer, Andrea ; Tremaroli, Valentina ; Steineck, Gunnar and Sjöberg, Fei
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dietary fiber, Oat bran, Pelvic radiotherapy, Radiation-induced inflammation, Serum cytokines
- in
- Nutrients
- volume
- 12
- issue
- 8
- article number
- 2172
- pages
- 26 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85088243410
- pmid:32707913
- ISSN
- 2072-6643
- DOI
- 10.3390/nu12082172
- language
- English
- LU publication?
- yes
- id
- 7b279f29-a918-4c7f-a0a2-1614acde8047
- date added to LUP
- 2020-10-01 09:54:04
- date last changed
- 2024-05-15 18:14:41
@article{7b279f29-a918-4c7f-a0a2-1614acde8047,
abstract = {{<p>Patients undergoing radiotherapy to treat pelvic-organ cancer are commonly advised to follow a restricted fiber diet. However, reducing dietary fiber may promote gastrointestinal inflammation, eventually leading to deteriorated intestinal health. The goal of this study was to evaluate the influence of dietary fiber on radiation-induced inflammation. C57BL/6J male mice were fed a High-oat bran diet (15% fiber) or a No-fiber diet (0% fiber) and were either irradiated (32 Gy delivered in four fractions) to the colorectal region or only sedated (controls). The dietary intervention started at 2 weeks before irradiation and lasted for 1, 6, and 18 weeks after irradiation, at which time points mice were sacrificed and their serum samples were assayed for 23 cytokines and chemokines. Our analyses show that irradiation increased the serum cytokine levels at all the time points analyzed. The No-fiber irradiated mice had significantly higher levels of pro-inflammatory cytokines than the High-oat irradiated mice at all time points. The results indicate that a fiber-rich oat bran diet reduces the intensity of radiation-induced inflammation, both at an early and late stage. Based on the results, it seems that the advice to follow a low-fiber diet during radiotherapy may increase the risk of decreased intestinal health in cancer survivors.</p>}},
author = {{Patel, Piyush and Malipatlolla, Dilip Kumar and Devarakonda, Sravani and Bull, Cecilia and Rascón, Ana and Nyman, Margareta and Stringer, Andrea and Tremaroli, Valentina and Steineck, Gunnar and Sjöberg, Fei}},
issn = {{2072-6643}},
keywords = {{Dietary fiber; Oat bran; Pelvic radiotherapy; Radiation-induced inflammation; Serum cytokines}},
language = {{eng}},
number = {{8}},
publisher = {{MDPI AG}},
series = {{Nutrients}},
title = {{Dietary oat bran reduces systemic inflammation in mice subjected to pelvic irradiation}},
url = {{http://dx.doi.org/10.3390/nu12082172}},
doi = {{10.3390/nu12082172}},
volume = {{12}},
year = {{2020}},
}