Advanced

Less pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.

Ekman, Carl LU ; Elgzyri, Targ LU ; Ström, Kristoffer LU ; Almgren, Peter LU ; Parikh, Hemang LU ; Dekker Nitert, Marloes LU ; Rönn, Tina LU ; Koivula, Fiona LU ; Ling, Charlotte LU and Tornberg, Åsa LU , et al. (2015) In Journal of Applied Physiology 119(9). p.953-960
Abstract
Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility when compared to subjects without heredity for diabetes (FH-). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response to exercise compared to FH-. 16 FH+ and 19 FH- insulin sensitive men similar in age, VO2peak and BMI completed an exercise intervention with heart rate monitoration during exercise for 7 months. Before and after the exercise intervention, the participants underwent a physical examination, tests for glucose tolerance and exercise capacity and muscle biopsies were taken for expression analysis. The participants attended on average 39 training sessions during the intervention... (More)
Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility when compared to subjects without heredity for diabetes (FH-). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response to exercise compared to FH-. 16 FH+ and 19 FH- insulin sensitive men similar in age, VO2peak and BMI completed an exercise intervention with heart rate monitoration during exercise for 7 months. Before and after the exercise intervention, the participants underwent a physical examination, tests for glucose tolerance and exercise capacity and muscle biopsies were taken for expression analysis. The participants attended on average 39 training sessions during the intervention and spent 18.8 MJ on exercise. VO2peak/kg increased by 14% and the participants lost 1.2 kg of weight and 3 cm waist circumference. Given that the FH+ group expended 61% more energy during the intervention, we used regression analysis to analyze the response in the FH+ and FH- groups separately. Exercise volume had a significant effect on VO2peak, weight and waist circumference in the FH- group, but not in the FH+ group. After exercise, expression of genes involved in metabolism, oxidative phosphorylation and cellular respiration increased more in the FH-, compared to the FH+ group. This suggests that healthy, insulin sensitive FH+ and FH- participants with similar age, VO2peak and BMI may respond differently to an exercise intervention. The FH+ background might limit muscle adaptation to exercise, which may contribute to the increased susceptibility to type 2 diabetes in FH+ individuals. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Applied Physiology
volume
119
issue
9
pages
953 - 960
publisher
American Physiological Society
external identifiers
  • pmid:26338460
  • wos:000364478200001
  • scopus:84946104150
ISSN
1522-1601
DOI
10.1152/japplphysiol.01067.2014
language
English
LU publication?
yes
id
e01a7666-09d4-4045-bc61-ce6b063a79d4 (old id 8043215)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26338460?dopt=Abstract
date added to LUP
2015-10-04 18:05:00
date last changed
2017-06-25 03:02:27
@article{e01a7666-09d4-4045-bc61-ce6b063a79d4,
  abstract     = {Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility when compared to subjects without heredity for diabetes (FH-). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response to exercise compared to FH-. 16 FH+ and 19 FH- insulin sensitive men similar in age, VO2peak and BMI completed an exercise intervention with heart rate monitoration during exercise for 7 months. Before and after the exercise intervention, the participants underwent a physical examination, tests for glucose tolerance and exercise capacity and muscle biopsies were taken for expression analysis. The participants attended on average 39 training sessions during the intervention and spent 18.8 MJ on exercise. VO2peak/kg increased by 14% and the participants lost 1.2 kg of weight and 3 cm waist circumference. Given that the FH+ group expended 61% more energy during the intervention, we used regression analysis to analyze the response in the FH+ and FH- groups separately. Exercise volume had a significant effect on VO2peak, weight and waist circumference in the FH- group, but not in the FH+ group. After exercise, expression of genes involved in metabolism, oxidative phosphorylation and cellular respiration increased more in the FH-, compared to the FH+ group. This suggests that healthy, insulin sensitive FH+ and FH- participants with similar age, VO2peak and BMI may respond differently to an exercise intervention. The FH+ background might limit muscle adaptation to exercise, which may contribute to the increased susceptibility to type 2 diabetes in FH+ individuals.},
  author       = {Ekman, Carl and Elgzyri, Targ and Ström, Kristoffer and Almgren, Peter and Parikh, Hemang and Dekker Nitert, Marloes and Rönn, Tina and Koivula, Fiona and Ling, Charlotte and Tornberg, Åsa and Wollmer, Per and Eriksson, Karl-Fredrik and Groop, Leif and Hansson, Ola},
  issn         = {1522-1601},
  language     = {eng},
  number       = {9},
  pages        = {953--960},
  publisher    = {American Physiological Society},
  series       = {Journal of Applied Physiology},
  title        = {Less pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.},
  url          = {http://dx.doi.org/10.1152/japplphysiol.01067.2014},
  volume       = {119},
  year         = {2015},
}