Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Cognitive interference processing in adults with childhood craniopharyngioma using functional magnetic resonance imaging

Svärd, Daniel LU ; Follin, Cecilia LU ; Fjalldal, Sigridur LU ; Hellerstedt, Robin LU ; Mannfolk, Peter LU ; Mårtensson, Johan LU ; Sundgren, Pia LU orcid and Erfurth, Eva Marie LU (2021) In Endocrine 74(3). p.714-722
Abstract

PURPOSE: To assess cognitive interference processing in adults with childhood craniopharyngioma (CP), with and without hypothalamic injury, respectively, in terms of behavioral performance and functional magnetic resonance imaging (fMRI) activity, using the multi-source interference task (MSIT).

METHODS: Twenty-eight CP patients (median age 34.5 [29.0-39.5] years) were investigated at median 20.5 (16.3-28.8) years after treatment with surgical resection and in some cases additional radiotherapy (n = 10) and compared to 29 matched controls (median age 37.0 [32.5-42.0] years). The subjects performed the MSIT during fMRI acquisition and behavioral performance in terms of response times (ms) and accuracy performance (%) were... (More)

PURPOSE: To assess cognitive interference processing in adults with childhood craniopharyngioma (CP), with and without hypothalamic injury, respectively, in terms of behavioral performance and functional magnetic resonance imaging (fMRI) activity, using the multi-source interference task (MSIT).

METHODS: Twenty-eight CP patients (median age 34.5 [29.0-39.5] years) were investigated at median 20.5 (16.3-28.8) years after treatment with surgical resection and in some cases additional radiotherapy (n = 10) and compared to 29 matched controls (median age 37.0 [32.5-42.0] years). The subjects performed the MSIT during fMRI acquisition and behavioral performance in terms of response times (ms) and accuracy performance (%) were recorded.

RESULTS: The MSIT activated the cingulo-fronto-parietal (CFP) attention network in both CP patients and controls. No differences were found in behavioral performance nor fMRI activity between CP patients (interference effect 333.9 [287.3-367.1] ms and 3.1 [1.6-5.6]%, respectively) and controls (309.1 [276.4-361.0] ms and 2.6 [1.6-4.9]%). No differences were found in behavioral performance nor fMRI activity between the two subgroups with (332.0 [283.6-353.4] ms and 4.2 [2.3-5.7]%, respectively) and without hypothalamic injury (355.7 [293.7-388.7] ms and 2.1 [1.0-5.2]%, respectively), respectively, and controls.

CONCLUSION: Adults with childhood CP performed cognitive interference processing equally well as controls and demonstrated no compensatory fMRI activity in the CFP attention network compared to controls. This was also true for the two subgroups with and without hypothalamic injury. The results can be useful to better characterize this condition, and to optimize treatment and support for these individuals.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Endocrine
volume
74
issue
3
pages
714 - 722
publisher
Humana Press
external identifiers
  • pmid:34292485
  • scopus:85111136133
ISSN
1355-008X
DOI
10.1007/s12020-021-02824-9
language
English
LU publication?
yes
id
8489bbdd-3f20-4aec-8dc5-bd8f68a8a080
date added to LUP
2021-07-29 18:51:01
date last changed
2022-08-04 18:02:16
@article{8489bbdd-3f20-4aec-8dc5-bd8f68a8a080,
  abstract     = {{<p>PURPOSE: To assess cognitive interference processing in adults with childhood craniopharyngioma (CP), with and without hypothalamic injury, respectively, in terms of behavioral performance and functional magnetic resonance imaging (fMRI) activity, using the multi-source interference task (MSIT).</p><p>METHODS: Twenty-eight CP patients (median age 34.5 [29.0-39.5] years) were investigated at median 20.5 (16.3-28.8) years after treatment with surgical resection and in some cases additional radiotherapy (n = 10) and compared to 29 matched controls (median age 37.0 [32.5-42.0] years). The subjects performed the MSIT during fMRI acquisition and behavioral performance in terms of response times (ms) and accuracy performance (%) were recorded.</p><p>RESULTS: The MSIT activated the cingulo-fronto-parietal (CFP) attention network in both CP patients and controls. No differences were found in behavioral performance nor fMRI activity between CP patients (interference effect 333.9 [287.3-367.1] ms and 3.1 [1.6-5.6]%, respectively) and controls (309.1 [276.4-361.0] ms and 2.6 [1.6-4.9]%). No differences were found in behavioral performance nor fMRI activity between the two subgroups with (332.0 [283.6-353.4] ms and 4.2 [2.3-5.7]%, respectively) and without hypothalamic injury (355.7 [293.7-388.7] ms and 2.1 [1.0-5.2]%, respectively), respectively, and controls.</p><p>CONCLUSION: Adults with childhood CP performed cognitive interference processing equally well as controls and demonstrated no compensatory fMRI activity in the CFP attention network compared to controls. This was also true for the two subgroups with and without hypothalamic injury. The results can be useful to better characterize this condition, and to optimize treatment and support for these individuals.</p>}},
  author       = {{Svärd, Daniel and Follin, Cecilia and Fjalldal, Sigridur and Hellerstedt, Robin and Mannfolk, Peter and Mårtensson, Johan and Sundgren, Pia and Erfurth, Eva Marie}},
  issn         = {{1355-008X}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{3}},
  pages        = {{714--722}},
  publisher    = {{Humana Press}},
  series       = {{Endocrine}},
  title        = {{Cognitive interference processing in adults with childhood craniopharyngioma using functional magnetic resonance imaging}},
  url          = {{http://dx.doi.org/10.1007/s12020-021-02824-9}},
  doi          = {{10.1007/s12020-021-02824-9}},
  volume       = {{74}},
  year         = {{2021}},
}