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Low serum levels of short-chain fatty acids after lactulose ingestion may indicate impaired colonic fermentation in patients with irritable bowel syndrome.

Undseth, Ragnhild; Jakobsdottir, Greta LU ; Nyman, Margareta LU ; Berstad, Arnold and Valeur, Jørgen (2015) In Clinical and Experimental Gastroenterology 8. p.303-308
Abstract
Ingestion of low-digestible carbohydrates triggers symptoms in patients with irritable bowel syndrome (IBS). These carbohydrates become substrates for microbial fermentation in the colon, yielding short-chain fatty acids (SCFAs) that are readily absorbed. Aiming to compare colonic fermentation in patients with IBS and healthy controls, we analyzed the concentrations of SCFA in serum at fasting and 90 minutes following ingestion of an unabsorbable, but fermentable carbohydrate, lactulose.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Experimental Gastroenterology
volume
8
pages
303 - 308
publisher
Dove Press
external identifiers
  • pmid:26664152
  • scopus:84949505107
ISSN
1178-7023
DOI
10.2147/CEG.S94084
language
English
LU publication?
yes
id
b0290d3d-78fa-4a96-ba13-b0d122cda822 (old id 8504880)
date added to LUP
2016-01-08 10:48:44
date last changed
2017-02-12 03:41:21
@article{b0290d3d-78fa-4a96-ba13-b0d122cda822,
  abstract     = {Ingestion of low-digestible carbohydrates triggers symptoms in patients with irritable bowel syndrome (IBS). These carbohydrates become substrates for microbial fermentation in the colon, yielding short-chain fatty acids (SCFAs) that are readily absorbed. Aiming to compare colonic fermentation in patients with IBS and healthy controls, we analyzed the concentrations of SCFA in serum at fasting and 90 minutes following ingestion of an unabsorbable, but fermentable carbohydrate, lactulose.},
  author       = {Undseth, Ragnhild and Jakobsdottir, Greta and Nyman, Margareta and Berstad, Arnold and Valeur, Jørgen},
  issn         = {1178-7023},
  language     = {eng},
  pages        = {303--308},
  publisher    = {Dove Press},
  series       = {Clinical and Experimental Gastroenterology},
  title        = {Low serum levels of short-chain fatty acids after lactulose ingestion may indicate impaired colonic fermentation in patients with irritable bowel syndrome.},
  url          = {http://dx.doi.org/10.2147/CEG.S94084},
  volume       = {8},
  year         = {2015},
}