Anti-prothrombin antibodies are associated with thrombosis in children.
Rask, Olof LU ; Hillarp, Andreas LU ; Berntorp, Erik LU and Ljung, Rolf LU
(2010)
In Thrombosis Research
125.
p.19-24
- Abstract
- INTRODUCTION: This investigation aimed to evaluate thrombotic risk factors in children, with special reference to autoantibodies against prothrombin and protein S. MATERIALS AND METHODS: We studied 57 consecutive Swedish children and adolescents referred with a radiologically confirmed acute thrombotic event. Clinical data were collected and a thrombophilia investigation was performed, including analysis of autoantibodies against protein S (anti-PS) and prothrombin (anti-PT). The anti-PS and anti-PT autoantibodies were also investigated in sera from 47 healthy controls. Detection of autoantibodies was performed by quantitative enzyme-linked immunosorbent assays. RESULTS: Results for anti-PT antibodies were positive in 21% (12/57) of the... (More)
- INTRODUCTION: This investigation aimed to evaluate thrombotic risk factors in children, with special reference to autoantibodies against prothrombin and protein S. MATERIALS AND METHODS: We studied 57 consecutive Swedish children and adolescents referred with a radiologically confirmed acute thrombotic event. Clinical data were collected and a thrombophilia investigation was performed, including analysis of autoantibodies against protein S (anti-PS) and prothrombin (anti-PT). The anti-PS and anti-PT autoantibodies were also investigated in sera from 47 healthy controls. Detection of autoantibodies was performed by quantitative enzyme-linked immunosorbent assays. RESULTS: Results for anti-PT antibodies were positive in 21% (12/57) of the patients and 2.1% (1/47) of the controls (OR 12.0, 95% CI 1.7-534; p=0.005). Seven percent (4/57) of the patients and 2.1% (1/47) of the controls were positive for anti-PS antibodies (OR 3.4, 95% CI 0.3-174; p>0.30). The FV G1691A mutation was found in 25% (14/57), and 44% (25/57) had 2 or more prothrombotic risk factors. Sixty percent (34/57) of the thrombosis patients were female. Peaks in frequency of thromboembolic events were found in the neonatal and the adolescent periods. Fifty-three percent (30/57) had thrombosis in the lower venous system. Associated clinical conditions occurred in 91% (52/57): systemic illness in 31% (18/57), infections in 26% (15/57), and oral contraceptive use in 25% (14/57). Four percent (2/57) had no apparent clinical or prothrombotic risk factors. CONCLUSIONS: This study suggests that anti-PT autoantibodies may be common risk factors for thrombosis in children, and it confirms the multifactorial nature of pediatric thrombosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1367584
- author
- Rask, Olof
LU
; Hillarp, Andreas
LU
; Berntorp, Erik
LU
and Ljung, Rolf
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thrombosis Research
- volume
- 125
- pages
- 19 - 24
- publisher
- Elsevier
- external identifiers
-
- wos:000274937100006
- pmid:19303627
- scopus:76449084887
- ISSN
- 1879-2472
- DOI
- 10.1016/j.thromres.2009.02.007
- language
- English
- LU publication?
- yes
- id
- 864daa38-5091-4e32-8281-62197370c416 (old id 1367584)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19303627?dopt=Abstract
- date added to LUP
- 2016-04-04 08:34:40
- date last changed
- 2022-02-20 21:50:42
@article{864daa38-5091-4e32-8281-62197370c416,
abstract = {{INTRODUCTION: This investigation aimed to evaluate thrombotic risk factors in children, with special reference to autoantibodies against prothrombin and protein S. MATERIALS AND METHODS: We studied 57 consecutive Swedish children and adolescents referred with a radiologically confirmed acute thrombotic event. Clinical data were collected and a thrombophilia investigation was performed, including analysis of autoantibodies against protein S (anti-PS) and prothrombin (anti-PT). The anti-PS and anti-PT autoantibodies were also investigated in sera from 47 healthy controls. Detection of autoantibodies was performed by quantitative enzyme-linked immunosorbent assays. RESULTS: Results for anti-PT antibodies were positive in 21% (12/57) of the patients and 2.1% (1/47) of the controls (OR 12.0, 95% CI 1.7-534; p=0.005). Seven percent (4/57) of the patients and 2.1% (1/47) of the controls were positive for anti-PS antibodies (OR 3.4, 95% CI 0.3-174; p>0.30). The FV G1691A mutation was found in 25% (14/57), and 44% (25/57) had 2 or more prothrombotic risk factors. Sixty percent (34/57) of the thrombosis patients were female. Peaks in frequency of thromboembolic events were found in the neonatal and the adolescent periods. Fifty-three percent (30/57) had thrombosis in the lower venous system. Associated clinical conditions occurred in 91% (52/57): systemic illness in 31% (18/57), infections in 26% (15/57), and oral contraceptive use in 25% (14/57). Four percent (2/57) had no apparent clinical or prothrombotic risk factors. CONCLUSIONS: This study suggests that anti-PT autoantibodies may be common risk factors for thrombosis in children, and it confirms the multifactorial nature of pediatric thrombosis.}},
author = {{Rask, Olof and Hillarp, Andreas and Berntorp, Erik and Ljung, Rolf}},
issn = {{1879-2472}},
language = {{eng}},
pages = {{19--24}},
publisher = {{Elsevier}},
series = {{Thrombosis Research}},
title = {{Anti-prothrombin antibodies are associated with thrombosis in children.}},
url = {{http://dx.doi.org/10.1016/j.thromres.2009.02.007}},
doi = {{10.1016/j.thromres.2009.02.007}},
volume = {{125}},
year = {{2010}},
}