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Parkinson’s disease laterality : a 11C-PE2I PET imaging study

Roussakis, Andreas Antonios ; Zeng, Zhou ; Lao-Kaim, Nicholas P. ; Martin-Bastida, Antonio ; Piccini, Paola ; Barker, Roger A. LU ; Farrell, Krista ; Guzman, Natalie Valle ; He, Xiaoling and Lazic, Stanley E. , et al. (2020) In Journal of Neurology
Abstract

Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11C-PE2I BPND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement... (More)

Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11C-PE2I BPND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.

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type
Contribution to journal
publication status
published
subject
keywords
Asymmetry, Dopamine transporter, Parkinson’s disease, Positron emission tomography, Striatum
in
Journal of Neurology
publisher
Springer
external identifiers
  • pmid:32880071
  • scopus:85090092361
ISSN
0340-5354
DOI
10.1007/s00415-020-10204-y
language
English
LU publication?
yes
id
8968ecee-83fb-4fda-ade4-3b28a4d45d70
date added to LUP
2020-09-24 09:30:18
date last changed
2024-09-06 03:43:48
@article{8968ecee-83fb-4fda-ade4-3b28a4d45d70,
  abstract     = {{<p>Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. <sup>11</sup>C-PE2I non-displaceable binding potential (BP<sub>ND</sub>) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal <sup>11</sup>C-PE2I BP<sub>ND</sub> over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.</p>}},
  author       = {{Roussakis, Andreas Antonios and Zeng, Zhou and Lao-Kaim, Nicholas P. and Martin-Bastida, Antonio and Piccini, Paola and Barker, Roger A. and Farrell, Krista and Guzman, Natalie Valle and He, Xiaoling and Lazic, Stanley E. and Moore, Sarah and Morris, Robert and Tyers, Pamela and Wijeyekoon, Ruwani and Daft, Danielle and Hewitt, Sam and Dayal, Biswas and Foltynie, Thomas and Kefalopoulou, Zenobia and Mahlknecht, Philipp and Bjartmarz, Hjalmar and Björklund, Anders and Lindvall, Olle and Nelander-Wahlestedt, Jenny and Parmar, Malin and Paul, Gesine and Widner, Hakan and Church, Alistair and Dunnett, Stephen and Peall, Kathryn and Rosser, Anne and Gurruchaga, Jean Marc and Palfi, Stéphane and Piroth, Tobias and Winkler, Christian}},
  issn         = {{0340-5354}},
  keywords     = {{Asymmetry; Dopamine transporter; Parkinson’s disease; Positron emission tomography; Striatum}},
  language     = {{eng}},
  publisher    = {{Springer}},
  series       = {{Journal of Neurology}},
  title        = {{Parkinson’s disease laterality : a <sup>11</sup>C-PE2I PET imaging study}},
  url          = {{http://dx.doi.org/10.1007/s00415-020-10204-y}},
  doi          = {{10.1007/s00415-020-10204-y}},
  year         = {{2020}},
}