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Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures

Bengzon, Johan LU ; Hansson, Stefan R. LU orcid ; Hoffman, Beth J. and Lindvall, Olle LU (1999) In Brain Research 842(1). p.239-242
Abstract

Noradrenergic locus coeruleus (LC) efferents to the forebrain suppress seizures in several models of epilepsy. Using in situ hybridization, we demonstrate that tyrosine hydroxylase (TH) and norepinephrine transporter (NET) but not vesicular monoamine transporter 2 (VMAT2) mRNA levels are transiently elevated in LC neurons following kainic acid-induced status epilepticus. These increases of TH and NET mRNAs and presumably of the proteins themselves might enhance synthesis and reuptake of NE postictally.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epilepsy, Locus coeruleus, Monoamine transporter, Norepinephrine, Rat
in
Brain Research
volume
842
issue
1
pages
239 - 242
publisher
Elsevier
external identifiers
  • scopus:0033581345
  • pmid:10526118
ISSN
0006-8993
DOI
10.1016/S0006-8993(99)01874-0
language
English
LU publication?
yes
id
8d1b3f24-6992-4c74-a7b4-913cec435841
date added to LUP
2019-06-04 16:04:52
date last changed
2024-06-25 17:36:15
@article{8d1b3f24-6992-4c74-a7b4-913cec435841,
  abstract     = {{<p>Noradrenergic locus coeruleus (LC) efferents to the forebrain suppress seizures in several models of epilepsy. Using in situ hybridization, we demonstrate that tyrosine hydroxylase (TH) and norepinephrine transporter (NET) but not vesicular monoamine transporter 2 (VMAT2) mRNA levels are transiently elevated in LC neurons following kainic acid-induced status epilepticus. These increases of TH and NET mRNAs and presumably of the proteins themselves might enhance synthesis and reuptake of NE postictally.</p>}},
  author       = {{Bengzon, Johan and Hansson, Stefan R. and Hoffman, Beth J. and Lindvall, Olle}},
  issn         = {{0006-8993}},
  keywords     = {{Epilepsy; Locus coeruleus; Monoamine transporter; Norepinephrine; Rat}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{1}},
  pages        = {{239--242}},
  publisher    = {{Elsevier}},
  series       = {{Brain Research}},
  title        = {{Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures}},
  url          = {{http://dx.doi.org/10.1016/S0006-8993(99)01874-0}},
  doi          = {{10.1016/S0006-8993(99)01874-0}},
  volume       = {{842}},
  year         = {{1999}},
}