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Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Moskal, Aurélie ; Freisling, Heinz ; Byrnes, Graham ; Assi, Nada ; Fahey, Michael T. ; Jenab, Mazda ; Ferrari, Pietro ; Tjønneland, Anne ; Petersen, Kristina E N and Dahm, Christina C. , et al. (2016) In British Journal of Cancer 115(11). p.1430-1440
Abstract

Background:Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox... (More)

Background:Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.Results:During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk.Conclusions:Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Cancer
volume
115
issue
11
pages
11 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:84992144561
  • pmid:27764841
  • wos:000388719100022
ISSN
0007-0920
DOI
10.1038/bjc.2016.334
language
English
LU publication?
yes
id
8e5d3549-8421-4069-9d49-53af7cbee8d5
date added to LUP
2016-12-08 10:16:40
date last changed
2023-09-15 13:13:17
@article{8e5d3549-8421-4069-9d49-53af7cbee8d5,
  abstract     = {{<p>Background:Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.Results:During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk.Conclusions:Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.</p>}},
  author       = {{Moskal, Aurélie and Freisling, Heinz and Byrnes, Graham and Assi, Nada and Fahey, Michael T. and Jenab, Mazda and Ferrari, Pietro and Tjønneland, Anne and Petersen, Kristina E N and Dahm, Christina C. and Hansen, Camilla Plambeck and Affret, Aurélie and Boutron-Ruault, Marie Christine and Cadeau, Claire and Kühn, Tilman and Katzke, Verena and Iqbal, Khalid and Boeing, Heiner and Trichopoulou, Antonia and Bamia, Christina and Naska, Androniki and Masala, Giovanna and De Magistris, Maria Santucci and Sieri, Sabina and Tumino, Rosario and Sacerdote, Carlotta and Peeters, Petra H. and Bueno-De-Mesquita, Bas H. and Engeset, Dagrun and Licaj, Idlir and Skeie, Guri and Ardanaz, Eva and Buckland, Genevieve and Castaño, José M Huerta and Quirós, José R. and Amiano, Pilar and Molina-Portillo, Elena and Winkvist, Anna and Myte, Robin and Ericson, Ulrika and Sonestedt, Emily and Perez-Cornago, Aurora and Wareham, Nick and Khaw, Kay Tee and Huybrechts, Inge and Tsilidis, Konstantinos K. and Ward, Heather and Gunter, Marc J. and Slimani, Nadia}},
  issn         = {{0007-0920}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  pages        = {{1430--1440}},
  publisher    = {{Nature Publishing Group}},
  series       = {{British Journal of Cancer}},
  title        = {{Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study}},
  url          = {{http://dx.doi.org/10.1038/bjc.2016.334}},
  doi          = {{10.1038/bjc.2016.334}},
  volume       = {{115}},
  year         = {{2016}},
}