Serum levels of biomarkers related to severity staging of Raynaud’s phenomenon, neurosensory manifestations, and vibration exposure in patients with hand-arm vibration injury
(2024) In Scientific Reports 14(1).- Abstract
Our aim was to explore possible relationships between serum levels of biomarkers in patients with hand-arm vibration injury in relation to the severity of the vascular, i.e., Raynaud’s phenomenon (RP), and neurosensory manifestations, the current exposure level, and the duration of exposure. This study was of case series design and involved 92 patients diagnosed with hand-arm vibration injury. Jonckheere’s trend test was used to assess any association between serum levels of biomarkers and RP as well as neurosensory manifestations, graded by the International Consensus Criteria. Generalized linear models with adjustment for possible confounders were also used for associations between serum levels of biomarkers and; (1) severity of RP... (More)
Our aim was to explore possible relationships between serum levels of biomarkers in patients with hand-arm vibration injury in relation to the severity of the vascular, i.e., Raynaud’s phenomenon (RP), and neurosensory manifestations, the current exposure level, and the duration of exposure. This study was of case series design and involved 92 patients diagnosed with hand-arm vibration injury. Jonckheere’s trend test was used to assess any association between serum levels of biomarkers and RP as well as neurosensory manifestations, graded by the International Consensus Criteria. Generalized linear models with adjustment for possible confounders were also used for associations between serum levels of biomarkers and; (1) severity of RP recorded as the extent of finger blanching calculated with Griffin score, (2) vibration perception thresholds, (3) magnitude of current exposure as [A(8); (m/s2)] value, and (4) the duration of exposure in years. Serum levels of thrombomodulin, von Willebrand factor, calcitonin gene related peptide (CGRP), heat shock protein 27, and caspase-3 were positively associated with severity of RP. Serum levels of CGRP were positively associated with the neurosensory component. No associations with exposure were shown for these biomarkers. For Intercellular adhesion molecule 1 and monocyte chemoattractant protein 1, no associations were found with neither severity nor exposure. Levels of serum biomarkers associated with endothelial injury or dysfunction, inflammation, vasodilation, neuroprotection, and apoptosis were positively associated with the severity of hand-arm vibration injury.
(Less)
- author
- Tekavec, Eva
LU
; Nilsson, Tohr
; Dahlin, Lars B.
LU
; Huynh, Elizabeth LU ; Nordander, Catarina LU
; Riddar, Jakob LU and Kåredal, Monica LU
- organization
-
- Work-related musculoskeletal disorders (research group)
- Hand Surgery, Malmö (research group)
- EpiHealth: Epidemiology for Health
- Division of Occupational and Environmental Medicine, Lund University
- Metalund
- NanoLund: Centre for Nanoscience
- Genetic Occupational and Environmental Medicine (research group)
- LTH Profile Area: Nanoscience and Semiconductor Technology
- LTH Profile Area: Aerosols
- LU Profile Area: Light and Materials
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aβ fibers, Aδ fibers, C-fibers, Cold intolerance, Endothelial dysfunction, Grading of injury, Hand-arm vibration syndrome (HAVS), Neuroprotection, Occupational, Serum biomarkers, Vibration exposure
- in
- Scientific Reports
- volume
- 14
- issue
- 1
- article number
- 18128
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:39103464
- scopus:85200468190
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-024-68846-1
- language
- English
- LU publication?
- yes
- id
- 94a49e82-546e-4f04-8fb2-668a14f8c941
- date added to LUP
- 2024-08-27 15:33:41
- date last changed
- 2024-08-28 03:00:05
@article{94a49e82-546e-4f04-8fb2-668a14f8c941, abstract = {{<p>Our aim was to explore possible relationships between serum levels of biomarkers in patients with hand-arm vibration injury in relation to the severity of the vascular, i.e., Raynaud’s phenomenon (RP), and neurosensory manifestations, the current exposure level, and the duration of exposure. This study was of case series design and involved 92 patients diagnosed with hand-arm vibration injury. Jonckheere’s trend test was used to assess any association between serum levels of biomarkers and RP as well as neurosensory manifestations, graded by the International Consensus Criteria. Generalized linear models with adjustment for possible confounders were also used for associations between serum levels of biomarkers and; (1) severity of RP recorded as the extent of finger blanching calculated with Griffin score, (2) vibration perception thresholds, (3) magnitude of current exposure as [A(8); (m/s<sup>2</sup>)] value, and (4) the duration of exposure in years. Serum levels of thrombomodulin, von Willebrand factor, calcitonin gene related peptide (CGRP), heat shock protein 27, and caspase-3 were positively associated with severity of RP. Serum levels of CGRP were positively associated with the neurosensory component. No associations with exposure were shown for these biomarkers. For Intercellular adhesion molecule 1 and monocyte chemoattractant protein 1, no associations were found with neither severity nor exposure. Levels of serum biomarkers associated with endothelial injury or dysfunction, inflammation, vasodilation, neuroprotection, and apoptosis were positively associated with the severity of hand-arm vibration injury.</p>}}, author = {{Tekavec, Eva and Nilsson, Tohr and Dahlin, Lars B. and Huynh, Elizabeth and Nordander, Catarina and Riddar, Jakob and Kåredal, Monica}}, issn = {{2045-2322}}, keywords = {{Aβ fibers; Aδ fibers; C-fibers; Cold intolerance; Endothelial dysfunction; Grading of injury; Hand-arm vibration syndrome (HAVS); Neuroprotection; Occupational; Serum biomarkers; Vibration exposure}}, language = {{eng}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Serum levels of biomarkers related to severity staging of Raynaud’s phenomenon, neurosensory manifestations, and vibration exposure in patients with hand-arm vibration injury}}, url = {{http://dx.doi.org/10.1038/s41598-024-68846-1}}, doi = {{10.1038/s41598-024-68846-1}}, volume = {{14}}, year = {{2024}}, }