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Serum levels of biomarkers related to severity staging of Raynaud’s phenomenon, neurosensory manifestations, and vibration exposure in patients with hand-arm vibration injury

Tekavec, Eva LU ; Nilsson, Tohr ; Dahlin, Lars B. LU orcid ; Huynh, Elizabeth LU ; Nordander, Catarina LU orcid ; Riddar, Jakob LU and Kåredal, Monica LU orcid (2024) In Scientific Reports 14(1).
Abstract

Our aim was to explore possible relationships between serum levels of biomarkers in patients with hand-arm vibration injury in relation to the severity of the vascular, i.e., Raynaud’s phenomenon (RP), and neurosensory manifestations, the current exposure level, and the duration of exposure. This study was of case series design and involved 92 patients diagnosed with hand-arm vibration injury. Jonckheere’s trend test was used to assess any association between serum levels of biomarkers and RP as well as neurosensory manifestations, graded by the International Consensus Criteria. Generalized linear models with adjustment for possible confounders were also used for associations between serum levels of biomarkers and; (1) severity of RP... (More)

Our aim was to explore possible relationships between serum levels of biomarkers in patients with hand-arm vibration injury in relation to the severity of the vascular, i.e., Raynaud’s phenomenon (RP), and neurosensory manifestations, the current exposure level, and the duration of exposure. This study was of case series design and involved 92 patients diagnosed with hand-arm vibration injury. Jonckheere’s trend test was used to assess any association between serum levels of biomarkers and RP as well as neurosensory manifestations, graded by the International Consensus Criteria. Generalized linear models with adjustment for possible confounders were also used for associations between serum levels of biomarkers and; (1) severity of RP recorded as the extent of finger blanching calculated with Griffin score, (2) vibration perception thresholds, (3) magnitude of current exposure as [A(8); (m/s2)] value, and (4) the duration of exposure in years. Serum levels of thrombomodulin, von Willebrand factor, calcitonin gene related peptide (CGRP), heat shock protein 27, and caspase-3 were positively associated with severity of RP. Serum levels of CGRP were positively associated with the neurosensory component. No associations with exposure were shown for these biomarkers. For Intercellular adhesion molecule 1 and monocyte chemoattractant protein 1, no associations were found with neither severity nor exposure. Levels of serum biomarkers associated with endothelial injury or dysfunction, inflammation, vasodilation, neuroprotection, and apoptosis were positively associated with the severity of hand-arm vibration injury.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aβ fibers, Aδ fibers, C-fibers, Cold intolerance, Endothelial dysfunction, Grading of injury, Hand-arm vibration syndrome (HAVS), Neuroprotection, Occupational, Serum biomarkers, Vibration exposure
in
Scientific Reports
volume
14
issue
1
article number
18128
publisher
Nature Publishing Group
external identifiers
  • pmid:39103464
  • scopus:85200468190
ISSN
2045-2322
DOI
10.1038/s41598-024-68846-1
language
English
LU publication?
yes
id
94a49e82-546e-4f04-8fb2-668a14f8c941
date added to LUP
2024-08-27 15:33:41
date last changed
2024-08-28 03:00:05
@article{94a49e82-546e-4f04-8fb2-668a14f8c941,
  abstract     = {{<p>Our aim was to explore possible relationships between serum levels of biomarkers in patients with hand-arm vibration injury in relation to the severity of the vascular, i.e., Raynaud’s phenomenon (RP), and neurosensory manifestations, the current exposure level, and the duration of exposure. This study was of case series design and involved 92 patients diagnosed with hand-arm vibration injury. Jonckheere’s trend test was used to assess any association between serum levels of biomarkers and RP as well as neurosensory manifestations, graded by the International Consensus Criteria. Generalized linear models with adjustment for possible confounders were also used for associations between serum levels of biomarkers and; (1) severity of RP recorded as the extent of finger blanching calculated with Griffin score, (2) vibration perception thresholds, (3) magnitude of current exposure as [A(8); (m/s<sup>2</sup>)] value, and (4) the duration of exposure in years. Serum levels of thrombomodulin, von Willebrand factor, calcitonin gene related peptide (CGRP), heat shock protein 27, and caspase-3 were positively associated with severity of RP. Serum levels of CGRP were positively associated with the neurosensory component. No associations with exposure were shown for these biomarkers. For Intercellular adhesion molecule 1 and monocyte chemoattractant protein 1, no associations were found with neither severity nor exposure. Levels of serum biomarkers associated with endothelial injury or dysfunction, inflammation, vasodilation, neuroprotection, and apoptosis were positively associated with the severity of hand-arm vibration injury.</p>}},
  author       = {{Tekavec, Eva and Nilsson, Tohr and Dahlin, Lars B. and Huynh, Elizabeth and Nordander, Catarina and Riddar, Jakob and Kåredal, Monica}},
  issn         = {{2045-2322}},
  keywords     = {{Aβ fibers; Aδ fibers; C-fibers; Cold intolerance; Endothelial dysfunction; Grading of injury; Hand-arm vibration syndrome (HAVS); Neuroprotection; Occupational; Serum biomarkers; Vibration exposure}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Serum levels of biomarkers related to severity staging of Raynaud’s phenomenon, neurosensory manifestations, and vibration exposure in patients with hand-arm vibration injury}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-68846-1}},
  doi          = {{10.1038/s41598-024-68846-1}},
  volume       = {{14}},
  year         = {{2024}},
}