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A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk

Mayén, Ana Lucia ; Viallon, Vivian ; Botteri, Edoardo ; Proust-Lima, Cecile ; Bagnardi, Vincenzo ; Batista, Veronica ; Cross, Amanda J. ; Laouali, Nasser ; MacDonald, Conor J. and Severi, Gianluca , et al. (2022) In European Journal of Epidemiology 37(9). p.915-929
Abstract

Background: Alcohol intake is an established risk factor for colorectal cancer (CRC); however, there is limited knowledge on whether changing alcohol drinking habits during adulthood modifies CRC risk. Objective: Leveraging longitudinal exposure assessments on alcohol intake at different ages, we examined the relationship between change in alcohol intake and subsequent CRC risk. Methods: Within the European Prospective Investigation into Cancer and Nutrition, changes in alcohol intake comparing follow-up with baseline assessments were investigated in relation to CRC risk. The analysis included 191,180, participants and 1530 incident CRC cases, with exclusion of the first three years of follow-up to minimize reverse causation. Trajectory... (More)

Background: Alcohol intake is an established risk factor for colorectal cancer (CRC); however, there is limited knowledge on whether changing alcohol drinking habits during adulthood modifies CRC risk. Objective: Leveraging longitudinal exposure assessments on alcohol intake at different ages, we examined the relationship between change in alcohol intake and subsequent CRC risk. Methods: Within the European Prospective Investigation into Cancer and Nutrition, changes in alcohol intake comparing follow-up with baseline assessments were investigated in relation to CRC risk. The analysis included 191,180, participants and 1530 incident CRC cases, with exclusion of the first three years of follow-up to minimize reverse causation. Trajectory profiles of alcohol intake, assessed at ages 20, 30, 40, 50 years, at baseline and during follow-up, were estimated using latent class mixed models and related to CRC risk, including 407,605 participants and 5,008 incident CRC cases. Results: Mean age at baseline was 50.2 years and the follow-up assessment occurred on average 7.1 years later. Compared to stable intake, a 12 g/day increase in alcohol intake during follow-up was positively associated with CRC risk (HR = 1.15, 95%CI 1.04, 1.25), while a 12 g/day reduction was inversely associated with CRC risk (HR = 0.86, 95%CI 0.78, 0.95). Trajectory analysis showed that compared to low alcohol intake, men who increased their alcohol intake from early- to mid- and late-adulthood by up to 30 g/day on average had significantly increased CRC risk (HR = 1.24; 95%CI 1.08, 1.42), while no associations were observed in women. Results were consistent by anatomical subsite. Conclusions: Increasing alcohol intake during mid-to-late adulthood raised CRC risk, while reduction lowered risk.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alcohol change, Alcohol intake, Colorectal cancer, Latent class mixed models, Longitudinal exposure, Trajectory profile analysis
in
European Journal of Epidemiology
volume
37
issue
9
pages
15 pages
publisher
Springer
external identifiers
  • scopus:85137464825
  • pmid:36063305
ISSN
0393-2990
DOI
10.1007/s10654-022-00900-6
language
English
LU publication?
yes
id
9725bdb1-4ce6-4063-89b4-4f729af46e7a
date added to LUP
2022-11-28 12:00:18
date last changed
2024-07-11 23:15:06
@article{9725bdb1-4ce6-4063-89b4-4f729af46e7a,
  abstract     = {{<p>Background: Alcohol intake is an established risk factor for colorectal cancer (CRC); however, there is limited knowledge on whether changing alcohol drinking habits during adulthood modifies CRC risk. Objective: Leveraging longitudinal exposure assessments on alcohol intake at different ages, we examined the relationship between change in alcohol intake and subsequent CRC risk. Methods: Within the European Prospective Investigation into Cancer and Nutrition, changes in alcohol intake comparing follow-up with baseline assessments were investigated in relation to CRC risk. The analysis included 191,180, participants and 1530 incident CRC cases, with exclusion of the first three years of follow-up to minimize reverse causation. Trajectory profiles of alcohol intake, assessed at ages 20, 30, 40, 50 years, at baseline and during follow-up, were estimated using latent class mixed models and related to CRC risk, including 407,605 participants and 5,008 incident CRC cases. Results: Mean age at baseline was 50.2 years and the follow-up assessment occurred on average 7.1 years later. Compared to stable intake, a 12 g/day increase in alcohol intake during follow-up was positively associated with CRC risk (HR = 1.15, 95%CI 1.04, 1.25), while a 12 g/day reduction was inversely associated with CRC risk (HR = 0.86, 95%CI 0.78, 0.95). Trajectory analysis showed that compared to low alcohol intake, men who increased their alcohol intake from early- to mid- and late-adulthood by up to 30 g/day on average had significantly increased CRC risk (HR = 1.24; 95%CI 1.08, 1.42), while no associations were observed in women. Results were consistent by anatomical subsite. Conclusions: Increasing alcohol intake during mid-to-late adulthood raised CRC risk, while reduction lowered risk.</p>}},
  author       = {{Mayén, Ana Lucia and Viallon, Vivian and Botteri, Edoardo and Proust-Lima, Cecile and Bagnardi, Vincenzo and Batista, Veronica and Cross, Amanda J. and Laouali, Nasser and MacDonald, Conor J. and Severi, Gianluca and Katzke, Verena and Bergmann, Manuela M. and Schulze, Mattias B. and Tjønneland, Anne and Eriksen, Anne Kirstine and Dahm, Christina C. and Antoniussen, Christian S. and Jakszyn, Paula and Sánchez, Maria Jose and Amiano, Pilar and Colorado-Yohar, Sandra M. and Ardanaz, Eva and Travis, Ruth and Palli, Domenico and Sabina, Sieri and Tumino, Rosario and Ricceri, Fulvio and Panico, Salvatore and Bueno-de-Mesquita, Bas and Derksen, Jeroen W.G. and Sonestedt, Emily and Winkvist, Anna and Harlid, Sophia and Braaten, Tonje and Gram, Inger Torhild and Lukic, Marko and Jenab, Mazda and Riboli, Elio and Freisling, Heinz and Weiderpass, Elisabete and Gunter, Marc J. and Ferrari, Pietro}},
  issn         = {{0393-2990}},
  keywords     = {{Alcohol change; Alcohol intake; Colorectal cancer; Latent class mixed models; Longitudinal exposure; Trajectory profile analysis}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{9}},
  pages        = {{915--929}},
  publisher    = {{Springer}},
  series       = {{European Journal of Epidemiology}},
  title        = {{A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk}},
  url          = {{http://dx.doi.org/10.1007/s10654-022-00900-6}},
  doi          = {{10.1007/s10654-022-00900-6}},
  volume       = {{37}},
  year         = {{2022}},
}