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Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer

Larsson, Christer LU ; Ehinger, Anna LU ; Winslow, Sofia LU ; Leandersson, Karin LU ; Klintman, Marie LU ; Dahl, Ludvig ; Vallon-christersson, Johan LU ; Häkkinen, Jari LU ; Hegardt, Cecilia LU and Manjer, Jonas LU , et al. (2020) In npj Breast Cancer 6(1).
Abstract
The extent and composition of the immune response in a breast cancer is one important prognostic factor for the disease. The aim of the current work was to refine the analysis of the humoral component of an immune response in breast tumors by quantifying mRNA expression of different immunoglobulin classes and study their association with prognosis. We used RNA-Seq data from two local population-based breast cancer cohorts to determine the expression of IGJ and immunoglobulin heavy (IGH) chain-encoding RNAs. The association with prognosis was investigated and public data sets were used to corroborate the findings. Except for IGHE and IGHD, mRNAs encoding heavy chains were generally detected at substantial levels and correlated with other... (More)
The extent and composition of the immune response in a breast cancer is one important prognostic factor for the disease. The aim of the current work was to refine the analysis of the humoral component of an immune response in breast tumors by quantifying mRNA expression of different immunoglobulin classes and study their association with prognosis. We used RNA-Seq data from two local population-based breast cancer cohorts to determine the expression of IGJ and immunoglobulin heavy (IGH) chain-encoding RNAs. The association with prognosis was investigated and public data sets were used to corroborate the findings. Except for IGHE and IGHD, mRNAs encoding heavy chains were generally detected at substantial levels and correlated with other immune-related genes. High IGHG1 mRNA was associated with factors related to poor prognosis such as estrogen receptor negativity, HER2 amplification, and high grade, whereas high IGHA2 mRNA levels were primarily associated with lower age at diagnosis. High IGHA2 and IGJ mRNA levels were associated with a more favorable prognosis both in univariable and multivariable Cox models. When adjusting for other prognostic factors, high IGHG1 mRNA levels were positively associated with improved prognosis. To our knowledge, these results are the first to demonstrate that expression of individual Ig class types has prognostic implications in breast cancer. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
npj Breast Cancer
volume
6
issue
1
article number
28
publisher
Nature Publishing Group
external identifiers
  • scopus:85087440418
  • pmid:32656317
ISSN
2374-4677
DOI
10.1038/s41523-020-0170-2
project
Sweden Cancerome Analysis Network - Breast (SCAN-B): a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine
language
English
LU publication?
yes
id
9a460b64-07cd-4f39-8ac7-cadcbcb8360c
date added to LUP
2020-07-09 10:12:59
date last changed
2021-01-06 09:04:42
@article{9a460b64-07cd-4f39-8ac7-cadcbcb8360c,
  abstract     = {The extent and composition of the immune response in a breast cancer is one important prognostic factor for the disease. The aim of the current work was to refine the analysis of the humoral component of an immune response in breast tumors by quantifying mRNA expression of different immunoglobulin classes and study their association with prognosis. We used RNA-Seq data from two local population-based breast cancer cohorts to determine the expression of IGJ and immunoglobulin heavy (IGH) chain-encoding RNAs. The association with prognosis was investigated and public data sets were used to corroborate the findings. Except for IGHE and IGHD, mRNAs encoding heavy chains were generally detected at substantial levels and correlated with other immune-related genes. High IGHG1 mRNA was associated with factors related to poor prognosis such as estrogen receptor negativity, HER2 amplification, and high grade, whereas high IGHA2 mRNA levels were primarily associated with lower age at diagnosis. High IGHA2 and IGJ mRNA levels were associated with a more favorable prognosis both in univariable and multivariable Cox models. When adjusting for other prognostic factors, high IGHG1 mRNA levels were positively associated with improved prognosis. To our knowledge, these results are the first to demonstrate that expression of individual Ig class types has prognostic implications in breast cancer.},
  author       = {Larsson, Christer and Ehinger, Anna and Winslow, Sofia and Leandersson, Karin and Klintman, Marie and Dahl, Ludvig and Vallon-christersson, Johan and Häkkinen, Jari and Hegardt, Cecilia and Manjer, Jonas and Saal, Lao and Rydén, Lisa and Malmberg, Martin and Borg, Åke and Loman, Niklas},
  issn         = {2374-4677},
  language     = {eng},
  month        = {07},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {npj Breast Cancer},
  title        = {Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer},
  url          = {http://dx.doi.org/10.1038/s41523-020-0170-2},
  doi          = {10.1038/s41523-020-0170-2},
  volume       = {6},
  year         = {2020},
}