Cognitive interference processing in adult survivors of childhood acute lymphoblastic leukemia using functional magnetic resonance imaging
(2022) In Acta Oncologica 61(3). p.333-340- Abstract
- Background: Childhood acute lymphoblastic leukemia (ALL) is associated with cognitive impairment in adulthood. Cognitive interference processing and its correlated functional magnetic resonance imaging (fMRI) activity in the brain have not yet been studied in this patient group.
Material: Twenty-six adult childhood ALL survivors (median [interquartile range {IQR}] age, 40.0 [37.0-42.3] years) were investigated at median age (IQR), 35.0 (32.0-37.0) years after treatment with intrathecal and intravenous chemotherapy as well as cranial radiotherapy (24 Gy) and compared with 26 matched controls (median [IQR] age, 37.5 [33.0-41.5] years).
Methods: Cognitive interference processing was investigated in terms of behavioral... (More) - Background: Childhood acute lymphoblastic leukemia (ALL) is associated with cognitive impairment in adulthood. Cognitive interference processing and its correlated functional magnetic resonance imaging (fMRI) activity in the brain have not yet been studied in this patient group.
Material: Twenty-six adult childhood ALL survivors (median [interquartile range {IQR}] age, 40.0 [37.0-42.3] years) were investigated at median age (IQR), 35.0 (32.0-37.0) years after treatment with intrathecal and intravenous chemotherapy as well as cranial radiotherapy (24 Gy) and compared with 26 matched controls (median [IQR] age, 37.5 [33.0-41.5] years).
Methods: Cognitive interference processing was investigated in terms of behavioral performance (response times [ms] and accuracy performance [%]) and fMRI activity in the cingulo-fronto-parietal (CFP) attention network as well as other parts of the brain using the multisource interference task (MSIT).
Results: ALL survivors had longer response times and reduced accuracy performance during cognitive interference processing (median [IQR] interference effect, 371.9 [314.7-453.3] ms and 6.7 [4.2-14.7]%, respectively) comparedwith controls (303.7 [275.0-376.7] ms and 2.3 [1.6-4.3]%, respectively), but did not exhibit altered fMRI activity in the CFP attention network or elsewhere in the brain.
Conclusion: Adult childhood ALL survivors demonstrated impaired behavioral performance but no altered fMRI activity when performing cognitive interference processing when compared with controls. The results can be used to better characterize this patient group and to optimize follow-up care and support for these individuals.
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Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/9c8521cc-6e74-4ab3-a26f-badea2b1eaa9
- author
- Svärd, Daniel LU ; Erfurth, Eva Marie LU ; Hellerstedt, Robin LU ; Mannfolk, Peter LU ; Mårtensson, Johan LU ; Sundgren, Pia LU and Follin, Cecilia LU
- organization
-
- Diagnostic Radiology, (Lund)
- Endocrine (research group)
- Department of Psychology
- Medical Radiation Physics, Lund
- MR Physics (research group)
- Logopedics, Phoniatrics and Audiology
- Lund University Bioimaging Center
- LUCC: Lund University Cancer Centre
- Late effects after childhood cancer treatment (research group)
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute lymphoblastic leukemia, cognitive interference, fMRI, multisource interference task
- in
- Acta Oncologica
- volume
- 61
- issue
- 3
- pages
- 333 - 340
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:85116914285
- pmid:34637675
- ISSN
- 1651-226X
- DOI
- 10.1080/0284186X.2021.1987514
- language
- English
- LU publication?
- yes
- id
- 9c8521cc-6e74-4ab3-a26f-badea2b1eaa9
- alternative location
- https://www.tandfonline.com/doi/full/10.1080/0284186X.2021.1987514?scroll=top&needAccess=true
- date added to LUP
- 2021-10-14 10:55:47
- date last changed
- 2023-11-13 11:22:58
@article{9c8521cc-6e74-4ab3-a26f-badea2b1eaa9, abstract = {{Background: Childhood acute lymphoblastic leukemia (ALL) is associated with cognitive impairment in adulthood. Cognitive interference processing and its correlated functional magnetic resonance imaging (fMRI) activity in the brain have not yet been studied in this patient group.<br/><br/>Material: Twenty-six adult childhood ALL survivors (median [interquartile range {IQR}] age, 40.0 [37.0-42.3] years) were investigated at median age (IQR), 35.0 (32.0-37.0) years after treatment with intrathecal and intravenous chemotherapy as well as cranial radiotherapy (24 Gy) and compared with 26 matched controls (median [IQR] age, 37.5 [33.0-41.5] years).<br/><br/>Methods: Cognitive interference processing was investigated in terms of behavioral performance (response times [ms] and accuracy performance [%]) and fMRI activity in the cingulo-fronto-parietal (CFP) attention network as well as other parts of the brain using the multisource interference task (MSIT).<br/><br/>Results: ALL survivors had longer response times and reduced accuracy performance during cognitive interference processing (median [IQR] interference effect, 371.9 [314.7-453.3] ms and 6.7 [4.2-14.7]%, respectively) comparedwith controls (303.7 [275.0-376.7] ms and 2.3 [1.6-4.3]%, respectively), but did not exhibit altered fMRI activity in the CFP attention network or elsewhere in the brain.<br/><br/>Conclusion: Adult childhood ALL survivors demonstrated impaired behavioral performance but no altered fMRI activity when performing cognitive interference processing when compared with controls. The results can be used to better characterize this patient group and to optimize follow-up care and support for these individuals.<br/>}}, author = {{Svärd, Daniel and Erfurth, Eva Marie and Hellerstedt, Robin and Mannfolk, Peter and Mårtensson, Johan and Sundgren, Pia and Follin, Cecilia}}, issn = {{1651-226X}}, keywords = {{Acute lymphoblastic leukemia; cognitive interference; fMRI; multisource interference task}}, language = {{eng}}, number = {{3}}, pages = {{333--340}}, publisher = {{Taylor & Francis}}, series = {{Acta Oncologica}}, title = {{Cognitive interference processing in adult survivors of childhood acute lymphoblastic leukemia using functional magnetic resonance imaging}}, url = {{http://dx.doi.org/10.1080/0284186X.2021.1987514}}, doi = {{10.1080/0284186X.2021.1987514}}, volume = {{61}}, year = {{2022}}, }