Inhalation and dermal uptake of particle and gas phase phthalates - A human chamber exposure study
(2018) 15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018 In 15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018- Abstract
We have exposed sixteen test subjects to particle and gas phase phthalates in the controlled chamber exposure study. Deuterium labelled phthalates were used to generate particle D4-DEHP (di(2-ethylhexyl) phthalate) and gas phase D4-DEP (diethyl phthalate) for exposures scenarios allowed studying the dermal only and combined inhalational and dermal uptake. Metabolites were measured in urine samples before and after three hours of exposure. The inhalation was the dominant route of uptake for both DEHP and DEP in this study design and exposure settings. Larger uptake of DEP compared to DEHP both via inhalation and dermal uptake was observed. Dermal uptake of DEHP was not observed in this study. Inhalational urinary excretion factors of the... (More)
We have exposed sixteen test subjects to particle and gas phase phthalates in the controlled chamber exposure study. Deuterium labelled phthalates were used to generate particle D4-DEHP (di(2-ethylhexyl) phthalate) and gas phase D4-DEP (diethyl phthalate) for exposures scenarios allowed studying the dermal only and combined inhalational and dermal uptake. Metabolites were measured in urine samples before and after three hours of exposure. The inhalation was the dominant route of uptake for both DEHP and DEP in this study design and exposure settings. Larger uptake of DEP compared to DEHP both via inhalation and dermal uptake was observed. Dermal uptake of DEHP was not observed in this study. Inhalational urinary excretion factors of the metabolites were found to be 0.73 for DEHP and 0.53 for DEP. This study also highlights the importance of taking into consideration the deposited dose of inhaled particles in studies of uptake of particles.
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- author
- Andersen, Christina LU ; Krais, Annette M. LU ; Eriksson, Axel C. LU ; Jakobsson, Jonas LU ; Löndahl, Jakob LU ; Lindh, Christian H. LU ; Pagels, Joakim LU ; Nielsen, Jörn LU ; Gudmundsson, Anders LU and Wierzbicka, Aneta LU
- organization
- publishing date
- 2018
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Dermal exposure, Inhalation, Lung deposition, Semi-volatile organic compounds (SVOCs)
- host publication
- 15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
- series title
- 15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
- publisher
- International Society of Indoor Air Quality and Climate (ISIAQ)
- conference name
- 15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
- conference location
- Philadelphia, United States
- conference dates
- 2018-07-22 - 2018-07-27
- external identifiers
-
- scopus:85105644498
- ISBN
- 9781713826514
- language
- English
- LU publication?
- yes
- id
- 9fa076e0-57e1-4d21-9cbb-83d4ab370e70
- date added to LUP
- 2021-05-28 14:58:04
- date last changed
- 2023-08-29 21:05:14
@inproceedings{9fa076e0-57e1-4d21-9cbb-83d4ab370e70, abstract = {{<p>We have exposed sixteen test subjects to particle and gas phase phthalates in the controlled chamber exposure study. Deuterium labelled phthalates were used to generate particle D4-DEHP (di(2-ethylhexyl) phthalate) and gas phase D4-DEP (diethyl phthalate) for exposures scenarios allowed studying the dermal only and combined inhalational and dermal uptake. Metabolites were measured in urine samples before and after three hours of exposure. The inhalation was the dominant route of uptake for both DEHP and DEP in this study design and exposure settings. Larger uptake of DEP compared to DEHP both via inhalation and dermal uptake was observed. Dermal uptake of DEHP was not observed in this study. Inhalational urinary excretion factors of the metabolites were found to be 0.73 for DEHP and 0.53 for DEP. This study also highlights the importance of taking into consideration the deposited dose of inhaled particles in studies of uptake of particles.</p>}}, author = {{Andersen, Christina and Krais, Annette M. and Eriksson, Axel C. and Jakobsson, Jonas and Löndahl, Jakob and Lindh, Christian H. and Pagels, Joakim and Nielsen, Jörn and Gudmundsson, Anders and Wierzbicka, Aneta}}, booktitle = {{15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018}}, isbn = {{9781713826514}}, keywords = {{Dermal exposure; Inhalation; Lung deposition; Semi-volatile organic compounds (SVOCs)}}, language = {{eng}}, publisher = {{International Society of Indoor Air Quality and Climate (ISIAQ)}}, series = {{15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018}}, title = {{Inhalation and dermal uptake of particle and gas phase phthalates - A human chamber exposure study}}, year = {{2018}}, }