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Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation

Zhang, Y; Danielsen, N LU ; Sundler, F LU and Mulder, H LU (1998) In NeuroReport 9(12). p.2833-2836
Abstract

The neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) is expressed in sensory neurons. Expression of several neuropeptides is up-regulated in sensory neurons following inflammation. To examine whether also PACAP expression is regulated by inflammation, PACAP expression in L5 dorsal root ganglion (DRG) was determined, using in situ hybridization, after unilateral adjuvant-induced inflammation in the rat paw. At 12 h and day 3, but not day 21, the percentage of neurons expressing PACAP mRNA was greater in the innervating L5 DRG. Similarly, PACAP mRNA expression in individual neurons was higher in the innervating L5 DRG at 12 h and day 3, but not day 21. Up-regulated PACAP expression following adjuvant injection suggests... (More)

The neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) is expressed in sensory neurons. Expression of several neuropeptides is up-regulated in sensory neurons following inflammation. To examine whether also PACAP expression is regulated by inflammation, PACAP expression in L5 dorsal root ganglion (DRG) was determined, using in situ hybridization, after unilateral adjuvant-induced inflammation in the rat paw. At 12 h and day 3, but not day 21, the percentage of neurons expressing PACAP mRNA was greater in the innervating L5 DRG. Similarly, PACAP mRNA expression in individual neurons was higher in the innervating L5 DRG at 12 h and day 3, but not day 21. Up-regulated PACAP expression following adjuvant injection suggests a role for PACAP in inflammation.

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keywords
Animals, Female, Freund's Adjuvant, Ganglia, Spinal, In Situ Hybridization, Inflammation, Neurons, Afferent, Neuropeptides, Pituitary Adenylate Cyclase-Activating Polypeptide, RNA, Messenger, Rats, Rats, Sprague-Dawley, Up-Regulation, Journal Article, Research Support, Non-U.S. Gov't
in
NeuroReport
volume
9
issue
12
pages
4 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0032563602
ISSN
0959-4965
language
English
LU publication?
yes
id
aadceb35-e2c4-401b-a913-c8d42f7fe688
date added to LUP
2017-10-13 13:13:42
date last changed
2017-11-24 13:15:28
@article{aadceb35-e2c4-401b-a913-c8d42f7fe688,
  abstract     = {<p>The neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) is expressed in sensory neurons. Expression of several neuropeptides is up-regulated in sensory neurons following inflammation. To examine whether also PACAP expression is regulated by inflammation, PACAP expression in L5 dorsal root ganglion (DRG) was determined, using in situ hybridization, after unilateral adjuvant-induced inflammation in the rat paw. At 12 h and day 3, but not day 21, the percentage of neurons expressing PACAP mRNA was greater in the innervating L5 DRG. Similarly, PACAP mRNA expression in individual neurons was higher in the innervating L5 DRG at 12 h and day 3, but not day 21. Up-regulated PACAP expression following adjuvant injection suggests a role for PACAP in inflammation.</p>},
  author       = {Zhang, Y and Danielsen, N and Sundler, F and Mulder, H},
  issn         = {0959-4965},
  keyword      = {Animals,Female,Freund's Adjuvant,Ganglia, Spinal,In Situ Hybridization,Inflammation,Neurons, Afferent,Neuropeptides,Pituitary Adenylate Cyclase-Activating Polypeptide,RNA, Messenger,Rats,Rats, Sprague-Dawley,Up-Regulation,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {08},
  number       = {12},
  pages        = {2833--2836},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation},
  volume       = {9},
  year         = {1998},
}