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Effects of whey proteins on glycaemia and insulinaemia to an oral glucose load in healthy adults; a dose-response study.

Gunnerud, Ulrika LU ; Östman, Elin LU and Björck, Inger LU (2013) In European Journal of Clinical Nutrition 67(7). p.749-753
Abstract
Background/Objectives:Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses.Subjects/Methods:Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference.Results:Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest... (More)
Background/Objectives:Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses.Subjects/Methods:Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference.Results:Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest doses, 18 g and 9 g, significantly reduced postprandial glycaemia (incremental area under the curve (iAUC) 0-120 min; P< 0.05). The 18 g dose significantly increased the insulin response (iAUC 0-120 min; P<0.05). All measured plasma AAs (15 in total), except glutamic acid, responded in a dose-dependent way, and the 9 and 18 g doses resulted in significantly higher plasma levels of AAs compared with the reference.Conclusions:Whey protein affects glycaemia, insulinaemia and plasma AAs to a glucose load in a dose-dependent manner. Comparatively low doses of whey protein (9 g) reduced postprandial glycaemia significantly when added to a carbohydrate-rich meal.European Journal of Clinical Nutrition advance online publication, 1 May 2013; doi:10.1038/ejcn.2013.88. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Clinical Nutrition
volume
67
issue
7
pages
749 - 753
publisher
Nature Publishing Group
external identifiers
  • wos:000321539800011
  • pmid:23632747
  • scopus:84880136206
  • pmid:23632747
ISSN
1476-5640
DOI
10.1038/ejcn.2013.88
project
ANTIDIABETIC FOOD CENTRE
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300)
id
ad011f64-ef4e-413e-b34e-55d1e639047d (old id 3805115)
date added to LUP
2016-04-01 10:57:27
date last changed
2023-11-10 09:24:38
@article{ad011f64-ef4e-413e-b34e-55d1e639047d,
  abstract     = {{Background/Objectives:Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses.Subjects/Methods:Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference.Results:Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest doses, 18 g and 9 g, significantly reduced postprandial glycaemia (incremental area under the curve (iAUC) 0-120 min; P&lt; 0.05). The 18 g dose significantly increased the insulin response (iAUC 0-120 min; P&lt;0.05). All measured plasma AAs (15 in total), except glutamic acid, responded in a dose-dependent way, and the 9 and 18 g doses resulted in significantly higher plasma levels of AAs compared with the reference.Conclusions:Whey protein affects glycaemia, insulinaemia and plasma AAs to a glucose load in a dose-dependent manner. Comparatively low doses of whey protein (9 g) reduced postprandial glycaemia significantly when added to a carbohydrate-rich meal.European Journal of Clinical Nutrition advance online publication, 1 May 2013; doi:10.1038/ejcn.2013.88.}},
  author       = {{Gunnerud, Ulrika and Östman, Elin and Björck, Inger}},
  issn         = {{1476-5640}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{749--753}},
  publisher    = {{Nature Publishing Group}},
  series       = {{European Journal of Clinical Nutrition}},
  title        = {{Effects of whey proteins on glycaemia and insulinaemia to an oral glucose load in healthy adults; a dose-response study.}},
  url          = {{http://dx.doi.org/10.1038/ejcn.2013.88}},
  doi          = {{10.1038/ejcn.2013.88}},
  volume       = {{67}},
  year         = {{2013}},
}