Effects of whey proteins on glycaemia and insulinaemia to an oral glucose load in healthy adults; a dose-response study.
(2013) In European Journal of Clinical Nutrition 67(7). p.749-753- Abstract
- Background/Objectives:Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses.Subjects/Methods:Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference.Results:Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest... (More)
- Background/Objectives:Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses.Subjects/Methods:Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference.Results:Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest doses, 18 g and 9 g, significantly reduced postprandial glycaemia (incremental area under the curve (iAUC) 0-120 min; P< 0.05). The 18 g dose significantly increased the insulin response (iAUC 0-120 min; P<0.05). All measured plasma AAs (15 in total), except glutamic acid, responded in a dose-dependent way, and the 9 and 18 g doses resulted in significantly higher plasma levels of AAs compared with the reference.Conclusions:Whey protein affects glycaemia, insulinaemia and plasma AAs to a glucose load in a dose-dependent manner. Comparatively low doses of whey protein (9 g) reduced postprandial glycaemia significantly when added to a carbohydrate-rich meal.European Journal of Clinical Nutrition advance online publication, 1 May 2013; doi:10.1038/ejcn.2013.88. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3805115
- author
- Gunnerud, Ulrika LU ; Östman, Elin LU and Björck, Inger LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Clinical Nutrition
- volume
- 67
- issue
- 7
- pages
- 749 - 753
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000321539800011
- pmid:23632747
- scopus:84880136206
- pmid:23632747
- ISSN
- 1476-5640
- DOI
- 10.1038/ejcn.2013.88
- project
- ANTIDIABETIC FOOD CENTRE
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300)
- id
- ad011f64-ef4e-413e-b34e-55d1e639047d (old id 3805115)
- date added to LUP
- 2016-04-01 10:57:27
- date last changed
- 2023-11-10 09:24:38
@article{ad011f64-ef4e-413e-b34e-55d1e639047d, abstract = {{Background/Objectives:Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses.Subjects/Methods:Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference.Results:Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest doses, 18 g and 9 g, significantly reduced postprandial glycaemia (incremental area under the curve (iAUC) 0-120 min; P< 0.05). The 18 g dose significantly increased the insulin response (iAUC 0-120 min; P<0.05). All measured plasma AAs (15 in total), except glutamic acid, responded in a dose-dependent way, and the 9 and 18 g doses resulted in significantly higher plasma levels of AAs compared with the reference.Conclusions:Whey protein affects glycaemia, insulinaemia and plasma AAs to a glucose load in a dose-dependent manner. Comparatively low doses of whey protein (9 g) reduced postprandial glycaemia significantly when added to a carbohydrate-rich meal.European Journal of Clinical Nutrition advance online publication, 1 May 2013; doi:10.1038/ejcn.2013.88.}}, author = {{Gunnerud, Ulrika and Östman, Elin and Björck, Inger}}, issn = {{1476-5640}}, language = {{eng}}, number = {{7}}, pages = {{749--753}}, publisher = {{Nature Publishing Group}}, series = {{European Journal of Clinical Nutrition}}, title = {{Effects of whey proteins on glycaemia and insulinaemia to an oral glucose load in healthy adults; a dose-response study.}}, url = {{http://dx.doi.org/10.1038/ejcn.2013.88}}, doi = {{10.1038/ejcn.2013.88}}, volume = {{67}}, year = {{2013}}, }