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Vitamin D intervention and bone : A randomized clinical trial in fair- and dark-skinned children at northern latitudes

Åkeson, Pia Karlsland LU ; Åkesson, Kristina E. LU ; Lind, Torbjörn; Hernell, Olle; Silfverdal, Sven Arne and Öhlund, Inger (2018) In Journal of Pediatric Gastroenterology and Nutrition 67(3). p.388-394
Abstract

Objectives: The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter. Methods: In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n=206) with fair and dark skin in Sweden (55°N-63°N) received daily vitamin D supplements of 25μg, 10μg, or placebo (2μg) during 3 winter months. We measured BMD and BMC for total body (TB), total body less head (TBLH), femoral neck (FN), and spine at baseline and 4 months later. Intake of vitamin D and calcium, serum 25- hydroxy vitamin D (S-25[OH]D), and related parameters were analyzed. Results: Despite lower S-25(OH)D... (More)

Objectives: The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter. Methods: In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n=206) with fair and dark skin in Sweden (55°N-63°N) received daily vitamin D supplements of 25μg, 10μg, or placebo (2μg) during 3 winter months. We measured BMD and BMC for total body (TB), total body less head (TBLH), femoral neck (FN), and spine at baseline and 4 months later. Intake of vitamin D and calcium, serum 25- hydroxy vitamin D (S-25[OH]D), and related parameters were analyzed. Results: Despite lower S-25(OH)D in dark than fair-skinned children, BMD of TB (P=0.012) and TBLH (P=0.002) and BMC of TBLH (P=0.04) were higher at baseline and follow-up in those with dark skin. Delta (Δ) BMD and BMC of TB and TBLH did not differ between intervention and placebo groups, but FN-BMC increased more among dark-skinned children in the 25μg (P=0.038) and 10μg (P=0.027) groups compared to placebo. We found no associations between Δ S-25(OH)D, P-parathyroid hormone, P-alkaline phosphatase, and D BMD and BMC, respectively. Conclusions: BMD and BMC remained higher in dark- than fair-skinned children despite lower vitamin D status. Even though no difference in general was found in BMD or BMC after vitamin D intervention, the increase in FN-BMC in dark-skinned children may suggest an influence on bone in those with initially insufficient vitamin D status.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
25-hydroxyvitamin D, Bone mineral content, Bone mineral density, Child, Skin color
in
Journal of Pediatric Gastroenterology and Nutrition
volume
67
issue
3
pages
7 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85056758094
ISSN
0277-2116
DOI
10.1097/MPG.0000000000002031
language
English
LU publication?
yes
id
af7daa67-810d-47c0-a1cc-51d0b0863f53
date added to LUP
2018-11-28 10:50:45
date last changed
2019-08-14 04:28:24
@article{af7daa67-810d-47c0-a1cc-51d0b0863f53,
  abstract     = {<p>Objectives: The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter. Methods: In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n=206) with fair and dark skin in Sweden (55°N-63°N) received daily vitamin D supplements of 25μg, 10μg, or placebo (2μg) during 3 winter months. We measured BMD and BMC for total body (TB), total body less head (TBLH), femoral neck (FN), and spine at baseline and 4 months later. Intake of vitamin D and calcium, serum 25- hydroxy vitamin D (S-25[OH]D), and related parameters were analyzed. Results: Despite lower S-25(OH)D in dark than fair-skinned children, BMD of TB (P=0.012) and TBLH (P=0.002) and BMC of TBLH (P=0.04) were higher at baseline and follow-up in those with dark skin. Delta (Δ) BMD and BMC of TB and TBLH did not differ between intervention and placebo groups, but FN-BMC increased more among dark-skinned children in the 25μg (P=0.038) and 10μg (P=0.027) groups compared to placebo. We found no associations between Δ S-25(OH)D, P-parathyroid hormone, P-alkaline phosphatase, and D BMD and BMC, respectively. Conclusions: BMD and BMC remained higher in dark- than fair-skinned children despite lower vitamin D status. Even though no difference in general was found in BMD or BMC after vitamin D intervention, the increase in FN-BMC in dark-skinned children may suggest an influence on bone in those with initially insufficient vitamin D status.</p>},
  author       = {Åkeson, Pia Karlsland and Åkesson, Kristina E. and Lind, Torbjörn and Hernell, Olle and Silfverdal, Sven Arne and Öhlund, Inger},
  issn         = {0277-2116},
  keyword      = {25-hydroxyvitamin D,Bone mineral content,Bone mineral density,Child,Skin color},
  language     = {eng},
  number       = {3},
  pages        = {388--394},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Pediatric Gastroenterology and Nutrition},
  title        = {Vitamin D intervention and bone : A randomized clinical trial in fair- and dark-skinned children at northern latitudes},
  url          = {http://dx.doi.org/10.1097/MPG.0000000000002031},
  volume       = {67},
  year         = {2018},
}