Longitudinal prediction of falls and near falls frequencies in Parkinson's disease:a prospective cohort study
Lindholm, Beata LU ; Brogårdh, Christina LU ; Odin, Per LU
and Hagell, Peter
LU
(2021)
In Journal of Neurology
268(3).
p.997-1005
- Abstract
INTRODUCTION AND OBJECTIVE: Several prediction models for falls/near falls in Parkinson's disease (PD) have been proposed. However, longitudinal predictors of frequency of falls/near falls are poorly investigated. Therefore, we aimed to identify short- and long-term predictors of the number of falls/near falls in PD.
METHODS: A prospective cohort of 58 persons with PD was assessed at baseline (mean age and PD duration, 65 and 3.2 years, respectively) and 3.5 years later. Potential predictors were history of falls and near falls, comfortable gait speed, freezing of gate, dyskinesia, retropulsion, tandem gait (TG), pain, and cognition (Mini-Mental State Exam, MMSE). After each assessment, the participants registered a number of... (More)
INTRODUCTION AND OBJECTIVE: Several prediction models for falls/near falls in Parkinson's disease (PD) have been proposed. However, longitudinal predictors of frequency of falls/near falls are poorly investigated. Therefore, we aimed to identify short- and long-term predictors of the number of falls/near falls in PD.
METHODS: A prospective cohort of 58 persons with PD was assessed at baseline (mean age and PD duration, 65 and 3.2 years, respectively) and 3.5 years later. Potential predictors were history of falls and near falls, comfortable gait speed, freezing of gate, dyskinesia, retropulsion, tandem gait (TG), pain, and cognition (Mini-Mental State Exam, MMSE). After each assessment, the participants registered a number of falls/near falls during the following 6 months. Multivariate Poisson regression was used to identify short- and long-term predictors of a number of falls/near falls.
RESULTS: Baseline median (q1-q3) motor (UPDRS) and MMSE scores were 10 (6.75-14) and 28.5 (27-29), respectively. History of falls was the only significant short-time predictor [incidence rate ratio (IRR), 15.17] for the number of falls/near falls during 6 months following baseline. Abnormal TG (IRR, 3.77) and lower MMSE scores (IRR, 1.17) were short-term predictors 3.5 years later. Abnormal TG (IRR, 7.79) and lower MMSE scores (IRR, 1.49) at baseline were long-term predictors of the number of falls/near falls 3.5 years later.
CONCLUSION: Abnormal TG and MMSE scores predict the number of falls/near falls in short and long term, and may be indicative of disease progression. Our observations provide important additions to the evidence base for clinical fall prediction in PD.
(Less)
- author
- Lindholm, Beata
LU
; Brogårdh, Christina
LU
; Odin, Per
LU
and Hagell, Peter
LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neurology
- volume
- 268
- issue
- 3
- pages
- 997 - 1005
- publisher
- Springer
- external identifiers
-
- pmid:32970193
- scopus:85091420679
- ISSN
- 1432-1459
- DOI
- 10.1007/s00415-020-10234-6
- language
- English
- LU publication?
- yes
- id
- b0953c2a-fbf2-4dd3-bee3-a1fa6ad23018
- date added to LUP
- 2020-09-28 22:26:38
- date last changed
- 2024-06-28 00:57:00
@article{b0953c2a-fbf2-4dd3-bee3-a1fa6ad23018,
abstract = {{<p>INTRODUCTION AND OBJECTIVE: Several prediction models for falls/near falls in Parkinson's disease (PD) have been proposed. However, longitudinal predictors of frequency of falls/near falls are poorly investigated. Therefore, we aimed to identify short- and long-term predictors of the number of falls/near falls in PD.</p><p>METHODS: A prospective cohort of 58 persons with PD was assessed at baseline (mean age and PD duration, 65 and 3.2 years, respectively) and 3.5 years later. Potential predictors were history of falls and near falls, comfortable gait speed, freezing of gate, dyskinesia, retropulsion, tandem gait (TG), pain, and cognition (Mini-Mental State Exam, MMSE). After each assessment, the participants registered a number of falls/near falls during the following 6 months. Multivariate Poisson regression was used to identify short- and long-term predictors of a number of falls/near falls.</p><p>RESULTS: Baseline median (q1-q3) motor (UPDRS) and MMSE scores were 10 (6.75-14) and 28.5 (27-29), respectively. History of falls was the only significant short-time predictor [incidence rate ratio (IRR), 15.17] for the number of falls/near falls during 6 months following baseline. Abnormal TG (IRR, 3.77) and lower MMSE scores (IRR, 1.17) were short-term predictors 3.5 years later. Abnormal TG (IRR, 7.79) and lower MMSE scores (IRR, 1.49) at baseline were long-term predictors of the number of falls/near falls 3.5 years later.</p><p>CONCLUSION: Abnormal TG and MMSE scores predict the number of falls/near falls in short and long term, and may be indicative of disease progression. Our observations provide important additions to the evidence base for clinical fall prediction in PD.</p>}},
author = {{Lindholm, Beata and Brogårdh, Christina and Odin, Per and Hagell, Peter}},
issn = {{1432-1459}},
language = {{eng}},
number = {{3}},
pages = {{997--1005}},
publisher = {{Springer}},
series = {{Journal of Neurology}},
title = {{Longitudinal prediction of falls and near falls frequencies in Parkinson's disease:a prospective cohort study}},
url = {{http://dx.doi.org/10.1007/s00415-020-10234-6}},
doi = {{10.1007/s00415-020-10234-6}},
volume = {{268}},
year = {{2021}},
}