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Environment Matters: Synaptic Properties of Neurons Born in the Epileptic Adult Brain Develop to Reduce Excitability.

Jakubs, Katherine LU ; Nanobashvili, Avtandil LU ; Bonde, Sara LU ; Ekdahl Clementson, Christine LU ; Kokaia, Zaal LU ; Kokaia, Merab LU and Lindvall, Olle LU (2006) In Neuron 52(6). p.1047-1059
Abstract
Neural progenitors in the adult dentate gyrus continuously produce new functional granule cells. Here we used whole-cell patch-clamp recordings to explore whether a pathological environment influences synaptic properties of new granule cells labeled with a GFP-retroviral vector. Rats were exposed to a physiological stimulus, i.e., running, or a brain insult, i.e., status epilepticus, which gave rise to neuronal death, inflammation, and chronic seizures. Granule cells formed after these stimuli exhibited similar intrinsic membrane properties. However, the new neurons born into the pathological environment differed with respect to synaptic drive and short-term plasticity of both excitatory and inhibitory afferents. The new granule cells... (More)
Neural progenitors in the adult dentate gyrus continuously produce new functional granule cells. Here we used whole-cell patch-clamp recordings to explore whether a pathological environment influences synaptic properties of new granule cells labeled with a GFP-retroviral vector. Rats were exposed to a physiological stimulus, i.e., running, or a brain insult, i.e., status epilepticus, which gave rise to neuronal death, inflammation, and chronic seizures. Granule cells formed after these stimuli exhibited similar intrinsic membrane properties. However, the new neurons born into the pathological environment differed with respect to synaptic drive and short-term plasticity of both excitatory and inhibitory afferents. The new granule cells formed in the epileptic brain exhibited functional connectivity consistent with reduced excitability. We demonstrate a high degree of plasticity in synaptic inputs to adult-born new neurons, which could act to mitigate pathological brain function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuron
volume
52
issue
6
pages
1047 - 1059
publisher
Cell Press
external identifiers
  • wos:000243115100012
  • scopus:33845414645
ISSN
0896-6273
DOI
10.1016/j.neuron.2006.11.004
language
English
LU publication?
yes
id
b38149cf-edca-4818-a2a9-21cf7e4b40b4 (old id 163887)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17178407&dopt=Abstract
date added to LUP
2007-07-16 09:07:20
date last changed
2019-10-08 01:35:19
@article{b38149cf-edca-4818-a2a9-21cf7e4b40b4,
  abstract     = {Neural progenitors in the adult dentate gyrus continuously produce new functional granule cells. Here we used whole-cell patch-clamp recordings to explore whether a pathological environment influences synaptic properties of new granule cells labeled with a GFP-retroviral vector. Rats were exposed to a physiological stimulus, i.e., running, or a brain insult, i.e., status epilepticus, which gave rise to neuronal death, inflammation, and chronic seizures. Granule cells formed after these stimuli exhibited similar intrinsic membrane properties. However, the new neurons born into the pathological environment differed with respect to synaptic drive and short-term plasticity of both excitatory and inhibitory afferents. The new granule cells formed in the epileptic brain exhibited functional connectivity consistent with reduced excitability. We demonstrate a high degree of plasticity in synaptic inputs to adult-born new neurons, which could act to mitigate pathological brain function.},
  author       = {Jakubs, Katherine and Nanobashvili, Avtandil and Bonde, Sara and Ekdahl Clementson, Christine and Kokaia, Zaal and Kokaia, Merab and Lindvall, Olle},
  issn         = {0896-6273},
  language     = {eng},
  number       = {6},
  pages        = {1047--1059},
  publisher    = {Cell Press},
  series       = {Neuron},
  title        = {Environment Matters: Synaptic Properties of Neurons Born in the Epileptic Adult Brain Develop to Reduce Excitability.},
  url          = {http://dx.doi.org/10.1016/j.neuron.2006.11.004},
  volume       = {52},
  year         = {2006},
}