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Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Solans, Marta; Benavente, Yolanda; Saez, Marc; Agudo, Antonio; Jakszyn, Paula; Naudin, Sabine; Hosnijeh, Fatemeh Saberi; Gunter, Marc; Huybrechts, Inge and Ferrari, Pietro, et al. (2019) In European Journal of Nutrition
Abstract

Introduction: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. Methods: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory... (More)

Introduction: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. Methods: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. Results: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). Conclusions: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.

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Chronic inflammation, Inflammatory score of the diet, Lymphoma, Nutrition, Prospective studies
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European Journal of Nutrition
publisher
Springer
external identifiers
  • scopus:85064081118
ISSN
1436-6207
DOI
10.1007/s00394-019-01947-0
language
English
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yes
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b411c9fa-9caf-4e4b-885a-9a51f0cd7682
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2019-05-09 13:40:28
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2019-05-23 12:48:16
@article{b411c9fa-9caf-4e4b-885a-9a51f0cd7682,
  abstract     = {<p>Introduction: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. Methods: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. Results: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). Conclusions: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.</p>},
  author       = {Solans, Marta and Benavente, Yolanda and Saez, Marc and Agudo, Antonio and Jakszyn, Paula and Naudin, Sabine and Hosnijeh, Fatemeh Saberi and Gunter, Marc and Huybrechts, Inge and Ferrari, Pietro and Besson, Caroline and Mahamat-Saleh, Yahya and Boutron-Ruault, Marie Christine and Kühn, Tilman and Kaaks, Rudolf and Boeing, Heiner and Lasheras, Cristina and Sánchez, Maria Jose and Amiano, Pilar and Chirlaque, María Dolores and Ardanaz, Eva and Schmidt, Julie A. and Vineis, Paolo and Riboli, Elio and Trichopoulou, Antonia and Karakatsani, Anna and Valanou, Elisavet and Masala, Giovanna and Agnoli, Claudia and Tumino, Rosario and Sacerdote, Carlotta and Mattiello, Amalia and Skeie, Guri and Weiderpass, Elisabete and Jerkeman, Mats and Dias, Joana Alves and Späth, Florentin and Nilsson, Lena Maria and Dahm, Christina C. and Overvad, Kim and Petersen, Kristina Elin Nielsen and Tjønneland, Anne and de Sanjose, Silvia and Vermeulen, Roel and Nieters, Alexandra and Casabonne, Delphine},
  issn         = {1436-6207},
  keyword      = {Chronic inflammation,Inflammatory score of the diet,Lymphoma,Nutrition,Prospective studies},
  language     = {eng},
  publisher    = {Springer},
  series       = {European Journal of Nutrition},
  title        = {Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1007/s00394-019-01947-0},
  year         = {2019},
}