Consumption of ultraprocessed food and development of chronic kidney disease : the Tianjin Chronic Low-Grade Systemic Inflammation and Health and UK Biobank Cohort Studies
(2023) In The American journal of clinical nutrition 117(2). p.373-382- Abstract
- Background
Many ultraprocessed food (UPF)-derived by-products may play a role in the development of chronic kidney disease (CKD). Although several studies have assessed the association of UPFs with kidney function decline or CKD in various countries, no evidence has been shown in China and the United Kingdom.
Objectives
This study aims to evaluate the association between UPF consumption and risk of CKD in 2 large cohort studies from China and the United Kingdom.
Methods
In total, 23,775 and 102,332 participants without baseline CKD were enrolled in the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) and UK Biobank cohort studies, respectively. Information on UPF consumption was obtained... (More) - Background
Many ultraprocessed food (UPF)-derived by-products may play a role in the development of chronic kidney disease (CKD). Although several studies have assessed the association of UPFs with kidney function decline or CKD in various countries, no evidence has been shown in China and the United Kingdom.
Objectives
This study aims to evaluate the association between UPF consumption and risk of CKD in 2 large cohort studies from China and the United Kingdom.
Methods
In total, 23,775 and 102,332 participants without baseline CKD were enrolled in the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) and UK Biobank cohort studies, respectively. Information on UPF consumption was obtained from a validated food frequency questionnaire in the TCLSIH and 24-h dietary recalls in the UK Biobank cohort. CKD was defined as an estimated glomerular filtration rate of
Results
After a median follow-up of 4.0 and 10.1 y, the incidence rates of CKD were around 1.1% and 1.7% in the TCLSIH and UK Biobank cohorts, respectively. The multivariable hazard ratio [95% confidence interval] of CKD across increasing quartiles (quartiles 1–4) of UPF consumption were 1 (reference), 1.24 (0.89, 1.72), 1.30 (0.91, 1.87), and 1.58 (1.07, 2.34) (P for trend = 0.02) in the TCLSIH cohort and 1 (reference), 1.14 (1.00, 1.31), 1.16 (1.01, 1.33), and 1.25 (1.09, 1.43) (P for trend < 0.01) in the UK Biobank cohort, respectively.
Conclusions
Our finding indicated that higher UPF consumption is associated with a higher risk of CKD. Moreover, restricting UPF consumption may potentially benefit the prevention of CKD. Further clinical trials are required to clarify the causality. (Less)
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- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The American journal of clinical nutrition
- volume
- 117
- issue
- 2
- pages
- 373 - 382
- publisher
- Oxford University Press
- external identifiers
-
- pmid:36811571
- scopus:85149427417
- ISSN
- 1938-3207
- DOI
- 10.1016/j.ajcnut.2022.11.005
- language
- English
- LU publication?
- yes
- id
- b542123f-4c27-423c-8bf5-8865224c13af
- date added to LUP
- 2023-01-25 08:35:32
- date last changed
- 2023-09-01 15:43:40
@article{b542123f-4c27-423c-8bf5-8865224c13af,
abstract = {{Background<br/>Many ultraprocessed food (UPF)-derived by-products may play a role in the development of chronic kidney disease (CKD). Although several studies have assessed the association of UPFs with kidney function decline or CKD in various countries, no evidence has been shown in China and the United Kingdom.<br/><br/>Objectives<br/>This study aims to evaluate the association between UPF consumption and risk of CKD in 2 large cohort studies from China and the United Kingdom.<br/><br/>Methods<br/>In total, 23,775 and 102,332 participants without baseline CKD were enrolled in the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) and UK Biobank cohort studies, respectively. Information on UPF consumption was obtained from a validated food frequency questionnaire in the TCLSIH and 24-h dietary recalls in the UK Biobank cohort. CKD was defined as an estimated glomerular filtration rate of <br/>Results<br/>After a median follow-up of 4.0 and 10.1 y, the incidence rates of CKD were around 1.1% and 1.7% in the TCLSIH and UK Biobank cohorts, respectively. The multivariable hazard ratio [95% confidence interval] of CKD across increasing quartiles (quartiles 1–4) of UPF consumption were 1 (reference), 1.24 (0.89, 1.72), 1.30 (0.91, 1.87), and 1.58 (1.07, 2.34) (P for trend = 0.02) in the TCLSIH cohort and 1 (reference), 1.14 (1.00, 1.31), 1.16 (1.01, 1.33), and 1.25 (1.09, 1.43) (P for trend < 0.01) in the UK Biobank cohort, respectively.<br/><br/>Conclusions<br/>Our finding indicated that higher UPF consumption is associated with a higher risk of CKD. Moreover, restricting UPF consumption may potentially benefit the prevention of CKD. Further clinical trials are required to clarify the causality.}},
author = {{Gu, Yeqing and Li, Huiping and Ma, Hao and Zhang, Shunming and Meng, Ge and Zhang, Qing and Liu, Li and Wu, Hongmei and Zhang, Tingjing and Wang, Xuena and Zhang, Juanjuan and Sun, Shaomei and Wang, Xing and Zhou, Ming and Jia, Qiyu and Song, Kun and Liu, Qiang and Huang, Tao and Borné, Yan and Wang, Yaogang and Qi, Lu and Niu, Kaijun}},
issn = {{1938-3207}},
language = {{eng}},
number = {{2}},
pages = {{373--382}},
publisher = {{Oxford University Press}},
series = {{The American journal of clinical nutrition}},
title = {{Consumption of ultraprocessed food and development of chronic kidney disease : the Tianjin Chronic Low-Grade Systemic Inflammation and Health and UK Biobank Cohort Studies}},
url = {{http://dx.doi.org/10.1016/j.ajcnut.2022.11.005}},
doi = {{10.1016/j.ajcnut.2022.11.005}},
volume = {{117}},
year = {{2023}},
}