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Metabolic profiling of plasma in patients with irritable bowel syndrome after a 4-week starch- and sucrose-reduced diet

Stenlund, Hans ; Nilholm, Clara LU ; Chorell, Elin ; Roth, Bodil LU ; D’Amato, Mauro and Ohlsson, Bodil LU (2021) In Metabolites 11(7).
Abstract

A 4-week dietary intervention with a starch- and sucrose-restricted diet (SSRD) was conducted in patients with irritable bowel syndrome (IBS) to examine the metabolic profile in relation to nutrient intake and gastrointestinal symptoms. IBS patients were randomized to SSRD intervention (n = 69) or control continuing with their ordinary food habits (n = 22). Food intake was registered and the questionnaires IBS-symptoms severity scale (IBS-SSS) and visual analog scale for IBS (VAS-IBS) were completed. Metabolomics untargeted analysis was performed by gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) in positive and negative ionization modes. SSRD led to marked changes in circulating... (More)

A 4-week dietary intervention with a starch- and sucrose-restricted diet (SSRD) was conducted in patients with irritable bowel syndrome (IBS) to examine the metabolic profile in relation to nutrient intake and gastrointestinal symptoms. IBS patients were randomized to SSRD intervention (n = 69) or control continuing with their ordinary food habits (n = 22). Food intake was registered and the questionnaires IBS-symptoms severity scale (IBS-SSS) and visual analog scale for IBS (VAS-IBS) were completed. Metabolomics untargeted analysis was performed by gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) in positive and negative ionization modes. SSRD led to marked changes in circulating metabolite concentrations at the group level, most prominent for reduced starch intake and increased polyunsaturated fat, with small changes in the control group. On an individual level, the correlations were weak. The marked reduction in gastrointestinal symptoms did not correlate with the metabolic changes. SSRD was observed by clear metabolic effects mainly related to linoleic acid metabolism, fatty acid biosynthesis, and beta-oxidation.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dietary advice, IBS, Metabolic profiling, Metabolomics, Starch, Sucrose
in
Metabolites
volume
11
issue
7
article number
440
publisher
MDPI AG
external identifiers
  • pmid:34357334
  • scopus:85109844778
ISSN
2218-1989
DOI
10.3390/metabo11070440
language
English
LU publication?
yes
id
b5da0b1d-cf7c-47c6-9603-c7d19c7ac368
date added to LUP
2022-03-22 17:24:22
date last changed
2025-02-15 04:50:13
@article{b5da0b1d-cf7c-47c6-9603-c7d19c7ac368,
  abstract     = {{<p>A 4-week dietary intervention with a starch- and sucrose-restricted diet (SSRD) was conducted in patients with irritable bowel syndrome (IBS) to examine the metabolic profile in relation to nutrient intake and gastrointestinal symptoms. IBS patients were randomized to SSRD intervention (n = 69) or control continuing with their ordinary food habits (n = 22). Food intake was registered and the questionnaires IBS-symptoms severity scale (IBS-SSS) and visual analog scale for IBS (VAS-IBS) were completed. Metabolomics untargeted analysis was performed by gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) in positive and negative ionization modes. SSRD led to marked changes in circulating metabolite concentrations at the group level, most prominent for reduced starch intake and increased polyunsaturated fat, with small changes in the control group. On an individual level, the correlations were weak. The marked reduction in gastrointestinal symptoms did not correlate with the metabolic changes. SSRD was observed by clear metabolic effects mainly related to linoleic acid metabolism, fatty acid biosynthesis, and beta-oxidation.</p>}},
  author       = {{Stenlund, Hans and Nilholm, Clara and Chorell, Elin and Roth, Bodil and D’Amato, Mauro and Ohlsson, Bodil}},
  issn         = {{2218-1989}},
  keywords     = {{Dietary advice; IBS; Metabolic profiling; Metabolomics; Starch; Sucrose}},
  language     = {{eng}},
  number       = {{7}},
  publisher    = {{MDPI AG}},
  series       = {{Metabolites}},
  title        = {{Metabolic profiling of plasma in patients with irritable bowel syndrome after a 4-week starch- and sucrose-reduced diet}},
  url          = {{http://dx.doi.org/10.3390/metabo11070440}},
  doi          = {{10.3390/metabo11070440}},
  volume       = {{11}},
  year         = {{2021}},
}