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Immune response in blood before and after epileptic and psychogenic non-epileptic seizures

Ahl, Matilda LU ; Taylor, Marie K LU orcid ; Avdic, Una ; Lundin, Anna LU ; Andersson, My LU orcid ; Amandusson, Åsa ; Kumlien, Eva ; Compagno Strandberg, Maria LU and Ekdahl, Christine T LU (2023) In Heliyon 9(3).
Abstract


Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of... (More)


Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling independent of co-morbidities.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Heliyon
volume
9
issue
3
article number
e13938
publisher
Elsevier
external identifiers
  • pmid:36895367
  • scopus:85148723098
ISSN
2405-8440
DOI
10.1016/j.heliyon.2023.e13938
language
English
LU publication?
yes
additional info
© 2023 The Authors. Published by Elsevier Ltd.
id
b7f8d08b-2ad5-4637-afbb-3ae178e13500
date added to LUP
2023-03-13 09:27:36
date last changed
2024-04-15 00:24:38
@article{b7f8d08b-2ad5-4637-afbb-3ae178e13500,
  abstract     = {{<p><br>
 Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling independent of co-morbidities.<br>
 </p>}},
  author       = {{Ahl, Matilda and Taylor, Marie K and Avdic, Una and Lundin, Anna and Andersson, My and Amandusson, Åsa and Kumlien, Eva and Compagno Strandberg, Maria and Ekdahl, Christine T}},
  issn         = {{2405-8440}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{Elsevier}},
  series       = {{Heliyon}},
  title        = {{Immune response in blood before and after epileptic and psychogenic non-epileptic seizures}},
  url          = {{http://dx.doi.org/10.1016/j.heliyon.2023.e13938}},
  doi          = {{10.1016/j.heliyon.2023.e13938}},
  volume       = {{9}},
  year         = {{2023}},
}