Recurring urothelial carcinomas show genomic rearrangements incompatible with a direct relationship
(2020) In Scientific Reports 10(1).- Abstract
We used the fact that patients with non-muscle invasive bladder tumors show local recurrences and multiple tumors to study re-initiation of tumor growth from the same urothelium. By extensive genomic analyses we show that tumors from the same patient are clonal. We show that gross genomic chromosomal aberrations may be detected in one tumor, only to be undetected in a recurrent tumor. By analyses of incompatible changes i.e., genomic alterations that cannot be reversed, we show that almost all tumors from a single patient may show such changes, thus the tumors cannot have originated from each other. As recurring tumors share both genomic alterations and driver gene mutations, these must have been present in the urothelium in periods... (More)
We used the fact that patients with non-muscle invasive bladder tumors show local recurrences and multiple tumors to study re-initiation of tumor growth from the same urothelium. By extensive genomic analyses we show that tumors from the same patient are clonal. We show that gross genomic chromosomal aberrations may be detected in one tumor, only to be undetected in a recurrent tumor. By analyses of incompatible changes i.e., genomic alterations that cannot be reversed, we show that almost all tumors from a single patient may show such changes, thus the tumors cannot have originated from each other. As recurring tumors share both genomic alterations and driver gene mutations, these must have been present in the urothelium in periods with no tumor growth. We present a model that includes a growing and evolving field of urothelial cells that occasionally, and locally, produce bursts of cellular growth leading to overt tumors.
(Less)
- author
- Marzouka, Nour Al Dain LU ; Lindgren, David LU ; Eriksson, Pontus LU ; Sjödahl, Gottfrid LU ; Bernardo, Carina LU ; Liedberg, Fredrik LU ; Axelson, Håkan LU and Höglund, Mattias LU
- organization
- publishing date
- 2020-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 10
- issue
- 1
- article number
- 19539
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:33177554
- scopus:85095851705
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-020-75854-4
- language
- English
- LU publication?
- yes
- id
- bcf6da3b-8177-46f5-b112-e1f6873e318b
- date added to LUP
- 2020-12-09 14:52:09
- date last changed
- 2024-09-19 11:45:43
@article{bcf6da3b-8177-46f5-b112-e1f6873e318b, abstract = {{<p>We used the fact that patients with non-muscle invasive bladder tumors show local recurrences and multiple tumors to study re-initiation of tumor growth from the same urothelium. By extensive genomic analyses we show that tumors from the same patient are clonal. We show that gross genomic chromosomal aberrations may be detected in one tumor, only to be undetected in a recurrent tumor. By analyses of incompatible changes i.e., genomic alterations that cannot be reversed, we show that almost all tumors from a single patient may show such changes, thus the tumors cannot have originated from each other. As recurring tumors share both genomic alterations and driver gene mutations, these must have been present in the urothelium in periods with no tumor growth. We present a model that includes a growing and evolving field of urothelial cells that occasionally, and locally, produce bursts of cellular growth leading to overt tumors.</p>}}, author = {{Marzouka, Nour Al Dain and Lindgren, David and Eriksson, Pontus and Sjödahl, Gottfrid and Bernardo, Carina and Liedberg, Fredrik and Axelson, Håkan and Höglund, Mattias}}, issn = {{2045-2322}}, language = {{eng}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Recurring urothelial carcinomas show genomic rearrangements incompatible with a direct relationship}}, url = {{http://dx.doi.org/10.1038/s41598-020-75854-4}}, doi = {{10.1038/s41598-020-75854-4}}, volume = {{10}}, year = {{2020}}, }