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Health-related quality of life and physical activity in Nordic patients with moderate haemophilia A and B (the MoHem study)

Måseide, Ragnhild J. ; Berntorp, Erik LU ; Astermark, Jan LU ; Olsson, Anna ; Bruzelius, Maria ; Frisk, Tony ; Nummi, Vuokko ; Lassila, Riitta ; Tjønnfjord, Geir E. and Holme, Pål A. (2023) In Haemophilia
Abstract

Introduction: The impact of moderate haemophilia on health-related quality of life (HRQoL) and physical activity (PA) is not well known. In previous studies, persons with factor VIII/factor IX activity (FVIII/FIX:C) below 3 IU/dL were associated with a more severe bleeding phenotype than predicted. Aim: To explore HRQoL and PA in patients with moderate haemophilia A (MHA) and B (MHB). Methods: A cross-sectional, multicentre study covering patients with MHA and MHB in Sweden, Finland, and Norway. HRQoL was assessed with the EuroQoL 5-Dimensions (EQ-5D) form and PA with the International Physical Activity Questionnaire among participants aged ≥15 years. Results: We report on 104 patients aged 15–84 years from the MoHem study. Overall,... (More)

Introduction: The impact of moderate haemophilia on health-related quality of life (HRQoL) and physical activity (PA) is not well known. In previous studies, persons with factor VIII/factor IX activity (FVIII/FIX:C) below 3 IU/dL were associated with a more severe bleeding phenotype than predicted. Aim: To explore HRQoL and PA in patients with moderate haemophilia A (MHA) and B (MHB). Methods: A cross-sectional, multicentre study covering patients with MHA and MHB in Sweden, Finland, and Norway. HRQoL was assessed with the EuroQoL 5-Dimensions (EQ-5D) form and PA with the International Physical Activity Questionnaire among participants aged ≥15 years. Results: We report on 104 patients aged 15–84 years from the MoHem study. Overall, EQ-5D utility was.85 (median) (Q1–Q3 0.73–1.0) with corresponding visual analogue scale (VAS) 80 (70–90), which were similar regardless of treatment modality, FVIII/FIX:C, and MHA or MHB. Pain and mobility were most frequently affected dimensions. Utility (r = -.54), VAS (r = -.42), and PA (r = -.32) correlated negatively with arthropathy (HJHS). Only patients aged 41–50 years displayed lower utility (p =.02) and VAS (p <.01) than the Norwegian population norm. Patients on prophylaxis aged 35–54 years reported higher PA than those treated on-demand (p =.01). Conclusion: Haemophilic arthropathy had negative impact on HRQoL and PA in Nordic patients with moderate haemophilia. Middle-aged patients captured lower utility and VAS than observed in the general population. Tailored prophylaxis and improved joint health may influence positively on HRQoL and PA also in moderate haemophilia.

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author
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organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
arthropathy, haemophilia A, haemophilia B, health-related quality of life, physical activity, prophylaxis
in
Haemophilia
publisher
Wiley-Blackwell
external identifiers
  • pmid:37983883
  • scopus:85177241153
ISSN
1351-8216
DOI
10.1111/hae.14899
language
English
LU publication?
yes
id
bdd1af2d-cf51-4cda-8b7c-ea8b25c7d8d7
date added to LUP
2024-01-09 11:05:14
date last changed
2024-04-24 07:02:22
@article{bdd1af2d-cf51-4cda-8b7c-ea8b25c7d8d7,
  abstract     = {{<p>Introduction: The impact of moderate haemophilia on health-related quality of life (HRQoL) and physical activity (PA) is not well known. In previous studies, persons with factor VIII/factor IX activity (FVIII/FIX:C) below 3 IU/dL were associated with a more severe bleeding phenotype than predicted. Aim: To explore HRQoL and PA in patients with moderate haemophilia A (MHA) and B (MHB). Methods: A cross-sectional, multicentre study covering patients with MHA and MHB in Sweden, Finland, and Norway. HRQoL was assessed with the EuroQoL 5-Dimensions (EQ-5D) form and PA with the International Physical Activity Questionnaire among participants aged ≥15 years. Results: We report on 104 patients aged 15–84 years from the MoHem study. Overall, EQ-5D utility was.85 (median) (Q1–Q3 0.73–1.0) with corresponding visual analogue scale (VAS) 80 (70–90), which were similar regardless of treatment modality, FVIII/FIX:C, and MHA or MHB. Pain and mobility were most frequently affected dimensions. Utility (r = -.54), VAS (r = -.42), and PA (r = -.32) correlated negatively with arthropathy (HJHS). Only patients aged 41–50 years displayed lower utility (p =.02) and VAS (p &lt;.01) than the Norwegian population norm. Patients on prophylaxis aged 35–54 years reported higher PA than those treated on-demand (p =.01). Conclusion: Haemophilic arthropathy had negative impact on HRQoL and PA in Nordic patients with moderate haemophilia. Middle-aged patients captured lower utility and VAS than observed in the general population. Tailored prophylaxis and improved joint health may influence positively on HRQoL and PA also in moderate haemophilia.</p>}},
  author       = {{Måseide, Ragnhild J. and Berntorp, Erik and Astermark, Jan and Olsson, Anna and Bruzelius, Maria and Frisk, Tony and Nummi, Vuokko and Lassila, Riitta and Tjønnfjord, Geir E. and Holme, Pål A.}},
  issn         = {{1351-8216}},
  keywords     = {{arthropathy; haemophilia A; haemophilia B; health-related quality of life; physical activity; prophylaxis}},
  language     = {{eng}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Haemophilia}},
  title        = {{Health-related quality of life and physical activity in Nordic patients with moderate haemophilia A and B (the MoHem study)}},
  url          = {{http://dx.doi.org/10.1111/hae.14899}},
  doi          = {{10.1111/hae.14899}},
  year         = {{2023}},
}