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Economic Evaluation of Interventions for Screening of Dementia

Saha, Sanjib LU ; Gerdtham, Ulf-Göran LU orcid ; Toresson, Håkan LU ; Minthon, Lennart LU and Jarl, Johan LU orcid (2018) In Working Papers
Abstract
OBJECTIVE: The objective is to systematically review the literature on economic evaluations of screening interventions for early diagnosis of dementia disorders. METHODS: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and we assessed if the conclusions made in terms of cost-effectiveness were supported by the reported evidence. The included studies were also assessed for reporting quality using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. RESULTS: Fourteen studies were identified and broadly... (More)
OBJECTIVE: The objective is to systematically review the literature on economic evaluations of screening interventions for early diagnosis of dementia disorders. METHODS: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and we assessed if the conclusions made in terms of cost-effectiveness were supported by the reported evidence. The included studies were also assessed for reporting quality using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. RESULTS: Fourteen studies were identified and broadly fell into two groups: screening without biomarkers and screening using biomarkers. There was a considerable heterogeneity in methodological approaches, target populations, study time frames, and perspectives as well as types of biomarkers used. The sensitivity and specificity of screening instruments are one of the important aspects in estimating the cost-effectiveness of the interventions. Cost-effectiveness of non-biomarker based interventions cannot be judged due to lack of information. The biomarkers based screening have the potential to be cost-effective but their effectiveness has to be established first. CONCLUSION: More economic evaluations studies as well as good quality effectiveness studies are required in screening strategies before these can be implemented in the clinical practice. (Less)
Abstract (Swedish)
Objective: The objective is to systematically review the literature on economic evaluations of screening interventions for early diagnosis of dementia disorders.
Methods: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and we assessed if the conclusions made in terms of cost-effectiveness were supported by the reported evidence. The included studies were also assessed for reporting quality using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: Fourteen studies were identified and... (More)
Objective: The objective is to systematically review the literature on economic evaluations of screening interventions for early diagnosis of dementia disorders.
Methods: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and we assessed if the conclusions made in terms of cost-effectiveness were supported by the reported evidence. The included studies were also assessed for reporting quality using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: Fourteen studies were identified and broadly fell into two groups: screening without biomarkers and screening using biomarkers. There was a considerable heterogeneity in methodological approaches, target populations, study time frames, and perspectives as well as types of biomarkers used. The sensitivity and specificity of screening instruments are one of the important aspects in estimating the cost-effectiveness of the interventions. Cost- effectivness of non-biomarker based interventions can not be judged due to lack of information. The biomarkers based screening have the potential to be cost-effective but their effectiveness has to be established first.
Conclusion: More economic evaluations studies as well as good quality effectiveness studies are required in screening strategies before these can be implemented in the clinical practice. Key words: Dementia, Screening, early diagnostic, economic evaluation (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Working paper/Preprint
publication status
published
subject
keywords
Dementia, Screening, early diagnostic, economic evaluation, Dementia, Screening, Early diagnostic, Economic evaluation, H43, I10, I18
in
Working Papers
issue
2018:20
pages
35 pages
language
English
LU publication?
yes
id
c599acbc-09f9-4086-9d3a-9a8fc189cacc
alternative location
https://swopec.hhs.se/lunewp/abs/lunewp2018_020.htm
date added to LUP
2018-09-04 12:31:51
date last changed
2019-10-17 02:21:21
@misc{c599acbc-09f9-4086-9d3a-9a8fc189cacc,
  abstract     = {OBJECTIVE: The objective is to systematically review the literature on economic evaluations of screening interventions for early diagnosis of dementia disorders. METHODS: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incremental cost-effectiveness ratio) and we assessed if the conclusions made in terms of cost-effectiveness were supported by the reported evidence. The included studies were also assessed for reporting quality using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. RESULTS: Fourteen studies were identified and broadly fell into two groups: screening without biomarkers and screening using biomarkers. There was a considerable heterogeneity in methodological approaches, target populations, study time frames, and perspectives as well as types of biomarkers used. The sensitivity and specificity of screening instruments are one of the important aspects in estimating the cost-effectiveness of the interventions. Cost-effectiveness of non-biomarker based interventions cannot be judged due to lack of information. The biomarkers based screening have the potential to be cost-effective but their effectiveness has to be established first. CONCLUSION: More economic evaluations studies as well as good quality effectiveness studies are required in screening strategies before these can be implemented in the clinical practice.},
  author       = {Saha, Sanjib and Gerdtham, Ulf-Göran and Toresson, Håkan and Minthon, Lennart and Jarl, Johan},
  language     = {eng},
  month        = {09},
  note         = {Working Paper},
  number       = {2018:20},
  series       = {Working Papers},
  title        = {Economic Evaluation of Interventions for Screening of Dementia},
  url          = {https://lup.lub.lu.se/search/files/50586475/wp18_20.pdf},
  year         = {2018},
}