Associations of the EAT-Lancet reference diet with metabolic dysfunction-associated steatotic liver disease and its severity : a multi-cohort study
(2024) In Hepatology- Abstract
BACKGROUND AIMS: The EAT-Lancet Commission devised a globally sustainable dietary pattern to jointly promote human health and sustainability. However, the extent to which this diet supports metabolic dysfunction-associated steatotic liver disease (MASLD) has not yet been assessed. This study aimed to investigate the association between the EAT-Lancet diet and risk of MASLD and its severity.
APPROACH RESULTS: This prospective multi-cohort study included 15,263 adults from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) cohort, 1,137 adults from the Guangzhou Nutrition and Health Study (GNHS) cohort, and 175,078 adults from the UK Biobank. Additionally, 228 Chinese adults from the Prospective Epidemic... (More)
BACKGROUND AIMS: The EAT-Lancet Commission devised a globally sustainable dietary pattern to jointly promote human health and sustainability. However, the extent to which this diet supports metabolic dysfunction-associated steatotic liver disease (MASLD) has not yet been assessed. This study aimed to investigate the association between the EAT-Lancet diet and risk of MASLD and its severity.
APPROACH RESULTS: This prospective multi-cohort study included 15,263 adults from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) cohort, 1,137 adults from the Guangzhou Nutrition and Health Study (GNHS) cohort, and 175,078 adults from the UK Biobank. Additionally, 228 Chinese adults from the Prospective Epidemic Research Specifically of Non-alcoholic Steatohepatitis (PERSONS) with biopsy-proven MASLD were included. An EAT-Lancet diet index was created to reflect adherence to the EAT-Lancet reference diet. The TCLSIH cohort recorded 3,010 MASLD cases during 53,575 person-years of follow-up, the GNHS cohort documented 624 MASLD cases during 6,454 person-years of follow-up, and the UK Biobank 1,350 developed MASLD cases during 1,745,432 person-years of follow-up. In multivariable models, participants in the highest tertiles of the EAT-Lancet diet index had a lower risk of MASLD compared with those in the lowest tertiles (TCLSIH: HR=0.87, 95% CI: 0.78, 0.96; GNHS: HR=0.79, 95% CI: 0.64, 0.98; UK Biobank: HR=0.73, 95% CI: 0.63, 0.85). Moreover, liver controlled attenuation parameter decreased with increasing the diet index in individuals with biopsy-proven MASLD (β=-5.895; 95% CI: -10.014, -1.775).
CONCLUSIONS: Adherence to the EAT-Lancet reference diet was inversely associated with risk of MASLD as well as its severity.
(Less)
- author
- Zhang, Shunming
LU
; Yan, Yan
; Zeng, Xu-Fen
; Gu, Yeqing
; Wu, Hongmei
; Zhang, Qing
LU
; Liu, Li
LU
; Huo, Zhenyu
; Luo, Xiaoqin
; Zhang, Rui
; Sonestedt, Emily
LU
; Borné, Yan
LU
; Qi, Lu
; Huang, Tao
; Zheng, Ming-Hua
; Chen, Yu-Ming
; Niu, Kaijun
and Ma, Le
(Less) - organization
- publishing date
- 2024-08-02
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Hepatology
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:39094016
- ISSN
- 1527-3350
- DOI
- 10.1097/HEP.0000000000001039
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2024 American Association for the Study of Liver Diseases.
- id
- c61fe142-2879-49a6-88b6-155dbbc29e2a
- date added to LUP
- 2024-08-05 22:40:21
- date last changed
- 2024-08-06 08:56:57
@article{c61fe142-2879-49a6-88b6-155dbbc29e2a,
abstract = {{<p>BACKGROUND AIMS: The EAT-Lancet Commission devised a globally sustainable dietary pattern to jointly promote human health and sustainability. However, the extent to which this diet supports metabolic dysfunction-associated steatotic liver disease (MASLD) has not yet been assessed. This study aimed to investigate the association between the EAT-Lancet diet and risk of MASLD and its severity.</p><p>APPROACH RESULTS: This prospective multi-cohort study included 15,263 adults from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) cohort, 1,137 adults from the Guangzhou Nutrition and Health Study (GNHS) cohort, and 175,078 adults from the UK Biobank. Additionally, 228 Chinese adults from the Prospective Epidemic Research Specifically of Non-alcoholic Steatohepatitis (PERSONS) with biopsy-proven MASLD were included. An EAT-Lancet diet index was created to reflect adherence to the EAT-Lancet reference diet. The TCLSIH cohort recorded 3,010 MASLD cases during 53,575 person-years of follow-up, the GNHS cohort documented 624 MASLD cases during 6,454 person-years of follow-up, and the UK Biobank 1,350 developed MASLD cases during 1,745,432 person-years of follow-up. In multivariable models, participants in the highest tertiles of the EAT-Lancet diet index had a lower risk of MASLD compared with those in the lowest tertiles (TCLSIH: HR=0.87, 95% CI: 0.78, 0.96; GNHS: HR=0.79, 95% CI: 0.64, 0.98; UK Biobank: HR=0.73, 95% CI: 0.63, 0.85). Moreover, liver controlled attenuation parameter decreased with increasing the diet index in individuals with biopsy-proven MASLD (β=-5.895; 95% CI: -10.014, -1.775).</p><p>CONCLUSIONS: Adherence to the EAT-Lancet reference diet was inversely associated with risk of MASLD as well as its severity.</p>}},
author = {{Zhang, Shunming and Yan, Yan and Zeng, Xu-Fen and Gu, Yeqing and Wu, Hongmei and Zhang, Qing and Liu, Li and Huo, Zhenyu and Luo, Xiaoqin and Zhang, Rui and Sonestedt, Emily and Borné, Yan and Qi, Lu and Huang, Tao and Zheng, Ming-Hua and Chen, Yu-Ming and Niu, Kaijun and Ma, Le}},
issn = {{1527-3350}},
language = {{eng}},
month = {{08}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Hepatology}},
title = {{Associations of the EAT-Lancet reference diet with metabolic dysfunction-associated steatotic liver disease and its severity : a multi-cohort study}},
url = {{http://dx.doi.org/10.1097/HEP.0000000000001039}},
doi = {{10.1097/HEP.0000000000001039}},
year = {{2024}},
}