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Fish consumption and breast cancer risk. The European Prospective Investigation into Cancer and Nutrition (EPIC)

Engeset, D; Alsaker, E; Lund, E; Welch, A; Khaw, KT; Clavel-Chapelon, F; Thiebaut, A; Chajes, V; Key, TJ and Allen, NE, et al. (2006) In International Journal of Cancer 119(1). p.175-182
Abstract
There is current interest in fish consumption and marine omega-3 (n-3) fatty acids and breast cancer risk. Some in vitro and animal studies have suggested an inhibitory effect of marine n-3 fatty acids on breast cancer growth, but the results from epidemiological studies that have examined the association between fish consumption and breast cancer risk in humans are inconsistent. We examined fish consumption and breast cancer risk in 310,671 women aged between 25 and 70 yr at recruitment into the European Prospective Investigation Into Cancer and Nutrition (EPIC). The participants completed a dietary questionnaire between 1992-98 and were followed up for incidence of breast cancer for a median of 6.4 yr. Hazard ratio for breast cancer by... (More)
There is current interest in fish consumption and marine omega-3 (n-3) fatty acids and breast cancer risk. Some in vitro and animal studies have suggested an inhibitory effect of marine n-3 fatty acids on breast cancer growth, but the results from epidemiological studies that have examined the association between fish consumption and breast cancer risk in humans are inconsistent. We examined fish consumption and breast cancer risk in 310,671 women aged between 25 and 70 yr at recruitment into the European Prospective Investigation Into Cancer and Nutrition (EPIC). The participants completed a dietary questionnaire between 1992-98 and were followed up for incidence of breast cancer for a median of 6.4 yr. Hazard ratio for breast cancer by intake of total and lean and fatty fish were estimated, stratified by study centre and adjusted for established breast cancer risk factors. During follow-up, 4,776 invasive incident breast cancers were reported. No significant associations between intake of total fish and breast cancer risk were observed, hazard ratio (HR) 1.01 (95% confidence interval [CI] 0.99-1.02; p = 0.28 per 10 g fish/day). When examining lean and ratty fish separately, we round a positive significant association only in the highest quintile for fatty fish (HR 1.13, 95% CI 1.01-1.26), but test for trend was not significant (p = 0.10). No associations with breast cancer risk were observed when the study participants were subdivided by menopausal status. Although the period of follow-up is relatively short, the results provide no evidence for an association between fish intake and breast cancer risk. (c) 2006 Wiley-Liss, Inc. (Less)
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published
subject
keywords
EPIC, fish consumption, breast cancer
in
International Journal of Cancer
volume
119
issue
1
pages
175 - 182
publisher
John Wiley & Sons
external identifiers
  • wos:000237430200025
  • pmid:16470807
  • scopus:33646500807
ISSN
0020-7136
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language
English
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yes
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c91d84b2-b9dc-4e1a-a046-c2f572567f26 (old id 409590)
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2007-10-02 17:16:14
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2018-05-29 12:05:36
@article{c91d84b2-b9dc-4e1a-a046-c2f572567f26,
  abstract     = {There is current interest in fish consumption and marine omega-3 (n-3) fatty acids and breast cancer risk. Some in vitro and animal studies have suggested an inhibitory effect of marine n-3 fatty acids on breast cancer growth, but the results from epidemiological studies that have examined the association between fish consumption and breast cancer risk in humans are inconsistent. We examined fish consumption and breast cancer risk in 310,671 women aged between 25 and 70 yr at recruitment into the European Prospective Investigation Into Cancer and Nutrition (EPIC). The participants completed a dietary questionnaire between 1992-98 and were followed up for incidence of breast cancer for a median of 6.4 yr. Hazard ratio for breast cancer by intake of total and lean and fatty fish were estimated, stratified by study centre and adjusted for established breast cancer risk factors. During follow-up, 4,776 invasive incident breast cancers were reported. No significant associations between intake of total fish and breast cancer risk were observed, hazard ratio (HR) 1.01 (95% confidence interval [CI] 0.99-1.02; p = 0.28 per 10 g fish/day). When examining lean and ratty fish separately, we round a positive significant association only in the highest quintile for fatty fish (HR 1.13, 95% CI 1.01-1.26), but test for trend was not significant (p = 0.10). No associations with breast cancer risk were observed when the study participants were subdivided by menopausal status. Although the period of follow-up is relatively short, the results provide no evidence for an association between fish intake and breast cancer risk. (c) 2006 Wiley-Liss, Inc.},
  author       = {Engeset, D and Alsaker, E and Lund, E and Welch, A and Khaw, KT and Clavel-Chapelon, F and Thiebaut, A and Chajes, V and Key, TJ and Allen, NE and Amiano, P and Dorronsoro, M and Tjonneland, A and Stripp, C and Peeters, PHM and van Gils, CH and Chirlaque, MD and Nagel, G and Linseisen, J and Ocke, MC and Bueno-De-Mesquita, HB and Sacerdote, C and Tumino, R and Ardanaz, E and Sanchez, MJ and Panico, S and Palli, D and Trichopoulou, A and Kalapothaki, V and Benetou, V and Quiros, JR and Agudo, A and Overvad, K and Bjerregaard, L and Wirfält, Elisabet and Schulz, M and Boeing, H and Slimani, N and Riboli, E},
  issn         = {0020-7136},
  keyword      = {EPIC,fish consumption,breast cancer},
  language     = {eng},
  number       = {1},
  pages        = {175--182},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Fish consumption and breast cancer risk. The European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/},
  volume       = {119},
  year         = {2006},
}