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Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother

Anderson, H LU ; Brandt, L LU ; Ericson, A ; Olsson, Håkan LU orcid and Möller, Torgil LU (1998) In Vox Sanguinis 75(2). p.145-148
Abstract

BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).

MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.

RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).

CONCLUSIONS: Blood transfusion at delivery is... (More)

BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).

MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.

RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).

CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Blood Transfusion, Case-Control Studies, Cohort Studies, Delivery, Obstetric, Female, Hodgkin Disease, Humans, Incidence, Lymphoma, Non-Hodgkin, Postpartum Hemorrhage, Pregnancy, Risk Factors, Sweden
in
Vox Sanguinis
volume
75
issue
2
pages
145 - 148
publisher
Wiley-Blackwell
external identifiers
  • pmid:9784669
  • scopus:0031721127
ISSN
0042-9007
language
English
LU publication?
yes
id
cbb74510-c64f-437f-a9fe-45882354d6fb
date added to LUP
2016-09-18 12:35:27
date last changed
2024-04-05 06:24:45
@article{cbb74510-c64f-437f-a9fe-45882354d6fb,
  abstract     = {{<p>BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).</p><p>MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.</p><p>RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).</p><p>CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.</p>}},
  author       = {{Anderson, H and Brandt, L and Ericson, A and Olsson, Håkan and Möller, Torgil}},
  issn         = {{0042-9007}},
  keywords     = {{Adult; Blood Transfusion; Case-Control Studies; Cohort Studies; Delivery, Obstetric; Female; Hodgkin Disease; Humans; Incidence; Lymphoma, Non-Hodgkin; Postpartum Hemorrhage; Pregnancy; Risk Factors; Sweden}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{145--148}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Vox Sanguinis}},
  title        = {{Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother}},
  volume       = {{75}},
  year         = {{1998}},
}