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Learned response sequences in cerebellar Purkinje cells

Jirenhed, Dan Anders LU ; Rasmussen, Anders LU ; Johansson, Fredrik LU and Hesslow, Germund LU (2017) In Proceedings of the National Academy of Sciences of the United States of America 114(23). p.6127-6132
Abstract

Associative learning in the cerebellum has previously focused on single movements. In eyeblink conditioning, for instance, a subject learns to blink at the right time in response to a conditional stimulus (CS), such as a tone that is repeatedly followed by an unconditional corneal stimulus (US). During conditioning, the CS and US are transmitted by mossy/parallel fibers and climbing fibers to cerebellar Purkinje cells that acquire a precisely timed pause response that drives the overt blink response. The timing of this conditional Purkinje cell response is determined by the CS-US interval and is independent of temporal patterns in the input signal. In addition to single movements, the cerebellum is also believed to be important for... (More)

Associative learning in the cerebellum has previously focused on single movements. In eyeblink conditioning, for instance, a subject learns to blink at the right time in response to a conditional stimulus (CS), such as a tone that is repeatedly followed by an unconditional corneal stimulus (US). During conditioning, the CS and US are transmitted by mossy/parallel fibers and climbing fibers to cerebellar Purkinje cells that acquire a precisely timed pause response that drives the overt blink response. The timing of this conditional Purkinje cell response is determined by the CS-US interval and is independent of temporal patterns in the input signal. In addition to single movements, the cerebellum is also believed to be important for learning complex motor programs that require multiple precisely timed muscle contractions, such as, for example, playing the piano. In the present work, we studied Purkinje cells in decerebrate ferrets that were conditioned using electrical stimulation of mossy fiber and climbing fiber afferents as CS and US, while alternating between short and long interstimulus intervals. We found that Purkinje cells can learn double pause responses, separated by an intermediate excitation, where each pause corresponds to one interstimulus interval. The results show that individual cells can not only learn to time a single response but that they also learn an accurately timed sequential response pattern.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebellum, Classical conditioning, Learning, Purkinje cells, Timing
in
Proceedings of the National Academy of Sciences of the United States of America
volume
114
issue
23
pages
6 pages
publisher
National Acad Sciences
external identifiers
  • scopus:85020480296
  • wos:000402703800083
ISSN
0027-8424
DOI
10.1073/pnas.1621132114
language
English
LU publication?
yes
id
cdb72f93-07dd-4579-8aac-e4dd4506cce2
date added to LUP
2017-06-26 16:26:13
date last changed
2018-01-07 12:09:04
@article{cdb72f93-07dd-4579-8aac-e4dd4506cce2,
  abstract     = {<p>Associative learning in the cerebellum has previously focused on single movements. In eyeblink conditioning, for instance, a subject learns to blink at the right time in response to a conditional stimulus (CS), such as a tone that is repeatedly followed by an unconditional corneal stimulus (US). During conditioning, the CS and US are transmitted by mossy/parallel fibers and climbing fibers to cerebellar Purkinje cells that acquire a precisely timed pause response that drives the overt blink response. The timing of this conditional Purkinje cell response is determined by the CS-US interval and is independent of temporal patterns in the input signal. In addition to single movements, the cerebellum is also believed to be important for learning complex motor programs that require multiple precisely timed muscle contractions, such as, for example, playing the piano. In the present work, we studied Purkinje cells in decerebrate ferrets that were conditioned using electrical stimulation of mossy fiber and climbing fiber afferents as CS and US, while alternating between short and long interstimulus intervals. We found that Purkinje cells can learn double pause responses, separated by an intermediate excitation, where each pause corresponds to one interstimulus interval. The results show that individual cells can not only learn to time a single response but that they also learn an accurately timed sequential response pattern.</p>},
  author       = {Jirenhed, Dan Anders and Rasmussen, Anders and Johansson, Fredrik and Hesslow, Germund},
  issn         = {0027-8424},
  keyword      = {Cerebellum,Classical conditioning,Learning,Purkinje cells,Timing},
  language     = {eng},
  month        = {06},
  number       = {23},
  pages        = {6127--6132},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences of the United States of America},
  title        = {Learned response sequences in cerebellar Purkinje cells},
  url          = {http://dx.doi.org/10.1073/pnas.1621132114},
  volume       = {114},
  year         = {2017},
}