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Extending imaging range in magnetomotive ultrasound with tailored magnetic nanoparticles

Evertsson, Maria LU ; Sjostrand, Sandra LU ; Kranemann, Tim C. ; Mousavi, Arefeh ; Svensson, Ingrid LU ; Cinthio, Magnus LU and Jansson, Tomas LU (2020) 2020 IEEE International Ultrasonics Symposium, IUS 2020 In IEEE International Ultrasonics Symposium, IUS 2020-September.
Abstract

In magnetomotive ultrasound (MMUS), magnetic nanoparticles (MNPs) are used as a contrast agent. A time-varying magnetic field displaces the MNPs which in turn move their closest surrounding - a motion detected with ultrasound. A limiting factor for MMUS is the magnetic force magnitude decay with depth, which restricts the imaging area. Several attempts to extend the imaging depth have been suggested, such as magnetic field generator configuration or choice of MNP core materials. In this study we present a new approach by modifying the design of the contrast agent using a commercially available nanoparticle with a nano-flower shaped iron oxide core (synomag®-D, micromod, Germany). In order to evaluate the performance of this particle, a... (More)

In magnetomotive ultrasound (MMUS), magnetic nanoparticles (MNPs) are used as a contrast agent. A time-varying magnetic field displaces the MNPs which in turn move their closest surrounding - a motion detected with ultrasound. A limiting factor for MMUS is the magnetic force magnitude decay with depth, which restricts the imaging area. Several attempts to extend the imaging depth have been suggested, such as magnetic field generator configuration or choice of MNP core materials. In this study we present a new approach by modifying the design of the contrast agent using a commercially available nanoparticle with a nano-flower shaped iron oxide core (synomag®-D, micromod, Germany). In order to evaluate the performance of this particle, a conventional particle (perimag®, micromod, Germany), was used for comparison. Using an electromagnet with a cone shaped iron core as a field generator, the induced MMUS displacement of the two MNP varieties where analyzed when altering the magnetic field strength and magnetic field frequency. Further, by using a more clinically relevant magnetic field setup, the depth where the synomag MNPs could produce significant MMUS displacement, was evaluated. The synomag MNPs produced a 1.8 times larger displacement than the perimag MNPs. At 52mm, MMUS displacement was still detectable using synomag MNPs. This indicates that the particle design plays an important role in MMUS imaging. Moreover, this study also confirms that MMUS imaging at clinically relevant depths is possible.

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author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Contrast agents, Magnetomotive ultrasound, Nanoparticle design, Nanoparticles
host publication
IUS 2020 - International Ultrasonics Symposium, Proceedings
series title
IEEE International Ultrasonics Symposium, IUS
volume
2020-September
article number
9251490
publisher
IEEE Computer Society
conference name
2020 IEEE International Ultrasonics Symposium, IUS 2020
conference location
Las Vegas, United States
conference dates
2020-09-07 - 2020-09-11
external identifiers
  • scopus:85097894114
ISSN
1948-5727
1948-5719
ISBN
9781728154480
DOI
10.1109/IUS46767.2020.9251490
language
English
LU publication?
yes
id
d34d00e5-952f-466a-8af7-80f426ea8f49
date added to LUP
2021-01-08 09:51:56
date last changed
2021-02-23 01:27:37
@inproceedings{d34d00e5-952f-466a-8af7-80f426ea8f49,
  abstract     = {<p>In magnetomotive ultrasound (MMUS), magnetic nanoparticles (MNPs) are used as a contrast agent. A time-varying magnetic field displaces the MNPs which in turn move their closest surrounding - a motion detected with ultrasound. A limiting factor for MMUS is the magnetic force magnitude decay with depth, which restricts the imaging area. Several attempts to extend the imaging depth have been suggested, such as magnetic field generator configuration or choice of MNP core materials. In this study we present a new approach by modifying the design of the contrast agent using a commercially available nanoparticle with a nano-flower shaped iron oxide core (synomag®-D, micromod, Germany). In order to evaluate the performance of this particle, a conventional particle (perimag®, micromod, Germany), was used for comparison. Using an electromagnet with a cone shaped iron core as a field generator, the induced MMUS displacement of the two MNP varieties where analyzed when altering the magnetic field strength and magnetic field frequency. Further, by using a more clinically relevant magnetic field setup, the depth where the synomag MNPs could produce significant MMUS displacement, was evaluated. The synomag MNPs produced a 1.8 times larger displacement than the perimag MNPs. At 52mm, MMUS displacement was still detectable using synomag MNPs. This indicates that the particle design plays an important role in MMUS imaging. Moreover, this study also confirms that MMUS imaging at clinically relevant depths is possible.</p>},
  author       = {Evertsson, Maria and Sjostrand, Sandra and Kranemann, Tim C. and Mousavi, Arefeh and Svensson, Ingrid and Cinthio, Magnus and Jansson, Tomas},
  booktitle    = {IUS 2020 - International Ultrasonics Symposium, Proceedings},
  isbn         = {9781728154480},
  issn         = {1948-5727},
  language     = {eng},
  publisher    = {IEEE Computer Society},
  series       = {IEEE International Ultrasonics Symposium, IUS},
  title        = {Extending imaging range in magnetomotive ultrasound with tailored magnetic nanoparticles},
  url          = {http://dx.doi.org/10.1109/IUS46767.2020.9251490},
  doi          = {10.1109/IUS46767.2020.9251490},
  volume       = {2020-September},
  year         = {2020},
}