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Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats

Nguyen, Thao Duy LU orcid ; Watanabe, Ayako LU ; Burleigh, Stephen LU ; Ghaffarzadegan, Tannaz LU ; Kanklai, Jirapat LU ; Prykhodko, Olena LU ; Hållenius, Frida LU orcid and Nyman, Margareta LU (2022) In Scientific Reports 12.
Abstract
Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain
fatty acids (SCFAs), have been shown to positively influence lipid
profile and biomarkers in the gut and brain. This study examined whether
MB and MV in high-fat diets, affected microbiota composition and
gut–blood–brain markers in apolipoprotein E deficient (ApoE-/-) rats, a
model for studies of lipid-associated disorders, and neurodegenerative
processes in Alzheimer’s disease (AD). ApoE-/- rats fed MB and MV
increased Tenericutes and the brain neurotransmitter
γ-aminobutyric acid (GABA), while the blood stress hormone
corticosterone decreased compared to control rats. Only rats that
received MB showed a... (More)
Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain
fatty acids (SCFAs), have been shown to positively influence lipid
profile and biomarkers in the gut and brain. This study examined whether
MB and MV in high-fat diets, affected microbiota composition and
gut–blood–brain markers in apolipoprotein E deficient (ApoE-/-) rats, a
model for studies of lipid-associated disorders, and neurodegenerative
processes in Alzheimer’s disease (AD). ApoE-/- rats fed MB and MV
increased Tenericutes and the brain neurotransmitter
γ-aminobutyric acid (GABA), while the blood stress hormone
corticosterone decreased compared to control rats. Only rats that
received MB showed a significant increase in cholic acid and Adlercreutzia in the caecum. In rats fed MV, the decrease of Proteobacteria
was associated with decreased corticosterone levels. Conclusively,
dietary supplementation of SCFA glycerol esters can modulate
gut–blood–brain markers and alter gut microbiota composition in ApoE-/-
rats, suggesting that SCFAs also could counteract lipid
disorders-related diseases. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
12
article number
15454
pages
11 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85137940789
  • pmid:36104381
ISSN
2045-2322
DOI
10.1038/s41598-022-19502-z
language
English
LU publication?
yes
id
d7552d02-26a5-4c77-8e7c-57792061d0fe
date added to LUP
2022-11-16 22:05:57
date last changed
2024-03-06 07:48:42
@article{d7552d02-26a5-4c77-8e7c-57792061d0fe,
  abstract     = {{Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain <br>
fatty acids (SCFAs), have been shown to positively influence lipid <br>
profile and biomarkers in the gut and brain. This study examined whether<br>
 MB and MV in high-fat diets, affected microbiota composition and <br>
gut–blood–brain markers in apolipoprotein E deficient (ApoE-/-) rats, a <br>
model for studies of lipid-associated disorders, and neurodegenerative <br>
processes in Alzheimer’s disease (AD). ApoE-/- rats fed MB and MV <br>
increased <i>Tenericutes</i> and the brain neurotransmitter <br>
γ-aminobutyric acid (GABA), while the blood stress hormone <br>
corticosterone decreased compared to control rats. Only rats that <br>
received MB showed a significant increase in cholic acid and <i>Adlercreutzia</i> in the caecum. In rats fed MV, the decrease of <i>Proteobacteria</i><br>
 was associated with decreased corticosterone levels. Conclusively, <br>
dietary supplementation of SCFA glycerol esters can modulate <br>
gut–blood–brain markers and alter gut microbiota composition in ApoE-/- <br>
rats, suggesting that SCFAs also could counteract lipid <br>
disorders-related diseases.}},
  author       = {{Nguyen, Thao Duy and Watanabe, Ayako and Burleigh, Stephen and Ghaffarzadegan, Tannaz and Kanklai, Jirapat and Prykhodko, Olena and Hållenius, Frida and Nyman, Margareta}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats}},
  url          = {{http://dx.doi.org/10.1038/s41598-022-19502-z}},
  doi          = {{10.1038/s41598-022-19502-z}},
  volume       = {{12}},
  year         = {{2022}},
}