Temporal trend of autonomic nerve function and HSP27, MIF and PAI-1 in type 1 diabetes
(2017) In Journal of Clinical and Translational Endocrinology 8. p.15-21- Abstract
- Aim Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c and their possible roles in effects of diabetes on the autonomic nervous system. Methods Patients with T1D (n = 32, 41% women) were recruited in 1985 and followed up on four occasions (1989, 1993, 1998, and 2005). Autonomic function was tested using expiration/inspiration (E/I-ratio). Blood samples, i.e. HSP27 (last three occasions), MIF, PAI-1 (last two occasions) and HbA1c (five occasions), were analyzed. Results Autonomic nerve function... (More)
- Aim Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c and their possible roles in effects of diabetes on the autonomic nervous system. Methods Patients with T1D (n = 32, 41% women) were recruited in 1985 and followed up on four occasions (1989, 1993, 1998, and 2005). Autonomic function was tested using expiration/inspiration (E/I-ratio). Blood samples, i.e. HSP27 (last three occasions), MIF, PAI-1 (last two occasions) and HbA1c (five occasions), were analyzed. Results Autonomic nerve function deteriorated over time during the 20-year-period, but levels of HSP27, MIF, and PAI-1 were not associated with cardiovascular autonomic neuropathy. MIF and PAI-1 were lower in T1D than in healthy controls in 2005. Increased HbA1c correlated with a decrease in E/I-ratio. Conclusions Neither the neuroprotective substance HSP27 nor the inflammatory substances, MIF and PAI-1 were associated with measures of cardiovascular autonomic nerve function, but a deterioration of such function was observed in relation to increasing HbA1c in T1D during a 20-year follow-up period. Improved glucose control might be associated with protection against autonomic neuropathy in T1D. (Less)
- Abstract (Swedish)
- Aim: Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c and their possible roles in effects of diabetes on the autonomic nervous system.
Methods: Patients with T1D (n = 32, 41% women) were recruited in 1985 and followed up on four occasions (1989, 1993, 1998, and 2005). Autonomic function was tested using expiration/inspiration (E/I-ratio). Blood samples, i.e. HSP27 (last three occasions), MIF, PAI-1 (last two occasions) and HbA1c (five occasions), were analyzed.
Results: Autonomic nerve... (More) - Aim: Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c and their possible roles in effects of diabetes on the autonomic nervous system.
Methods: Patients with T1D (n = 32, 41% women) were recruited in 1985 and followed up on four occasions (1989, 1993, 1998, and 2005). Autonomic function was tested using expiration/inspiration (E/I-ratio). Blood samples, i.e. HSP27 (last three occasions), MIF, PAI-1 (last two occasions) and HbA1c (five occasions), were analyzed.
Results: Autonomic nerve function deteriorated over time during the 20-year-period, but levels of HSP27, MIF, and PAI-1 were not associated with cardiovascular autonomic neuropathy. MIF and PAI-1 were lower in T1D than in healthy controls in 2005. Increased HbA1c correlated with a decrease in E/I-ratio.
Conclusions: Neither the neuroprotective substance HSP27 nor the inflammatory substances, MIF and PAI-1 were associated with measures of cardiovascular autonomic nerve function, but a deterioration of such function was observed in relation to increasing HbA1c in T1D during a 20-year follow-up period.
Improved glucose control might be associated with protection against autonomic neuropathy in T1D. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/d8889b8f-fb52-415f-b9e1-f6daaf8e5fed
- author
- Zimmerman, Malin
LU
; Rolandsson Enes, Sara LU
; Skärstrand, Hanna LU ; Pourhamidi, Kaveh ; Gottsäter, Anders LU ; Wollmer, Per LU ; Rolandsson, Olov ; Westergren-Thorsson, Gunilla LU
and Dahlin, Lars LU
- organization
- publishing date
- 2017-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- diabetes, autonom neuropati, HSP27, MIF, PAI-1, HbA1c
- in
- Journal of Clinical and Translational Endocrinology
- volume
- 8
- pages
- 15 - 21
- publisher
- Elsevier
- external identifiers
-
- scopus:85016142370
- wos:000405747800003
- pmid:29067254
- ISSN
- 2214-6237
- DOI
- 10.1016/j.jcte.2017.03.001
- language
- English
- LU publication?
- yes
- id
- d8889b8f-fb52-415f-b9e1-f6daaf8e5fed
- alternative location
- http://www.sciencedirect.com/science/article/pii/S2214623716300394
- date added to LUP
- 2017-03-28 20:05:43
- date last changed
- 2024-03-17 11:13:00
@article{d8889b8f-fb52-415f-b9e1-f6daaf8e5fed, abstract = {{Aim Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c and their possible roles in effects of diabetes on the autonomic nervous system. Methods Patients with T1D (n = 32, 41% women) were recruited in 1985 and followed up on four occasions (1989, 1993, 1998, and 2005). Autonomic function was tested using expiration/inspiration (E/I-ratio). Blood samples, i.e. HSP27 (last three occasions), MIF, PAI-1 (last two occasions) and HbA1c (five occasions), were analyzed. Results Autonomic nerve function deteriorated over time during the 20-year-period, but levels of HSP27, MIF, and PAI-1 were not associated with cardiovascular autonomic neuropathy. MIF and PAI-1 were lower in T1D than in healthy controls in 2005. Increased HbA1c correlated with a decrease in E/I-ratio. Conclusions Neither the neuroprotective substance HSP27 nor the inflammatory substances, MIF and PAI-1 were associated with measures of cardiovascular autonomic nerve function, but a deterioration of such function was observed in relation to increasing HbA1c in T1D during a 20-year follow-up period. Improved glucose control might be associated with protection against autonomic neuropathy in T1D.}}, author = {{Zimmerman, Malin and Rolandsson Enes, Sara and Skärstrand, Hanna and Pourhamidi, Kaveh and Gottsäter, Anders and Wollmer, Per and Rolandsson, Olov and Westergren-Thorsson, Gunilla and Dahlin, Lars}}, issn = {{2214-6237}}, keywords = {{diabetes; autonom neuropati; HSP27; MIF; PAI-1; HbA1c}}, language = {{eng}}, pages = {{15--21}}, publisher = {{Elsevier}}, series = {{Journal of Clinical and Translational Endocrinology}}, title = {{Temporal trend of autonomic nerve function and HSP27, MIF and PAI-1 in type 1 diabetes}}, url = {{http://dx.doi.org/10.1016/j.jcte.2017.03.001}}, doi = {{10.1016/j.jcte.2017.03.001}}, volume = {{8}}, year = {{2017}}, }