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Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

Geidenstam, Nina LU ; Magnusson, Martin LU orcid ; Danielsson, Anders P H LU ; Gerszten, Robert E ; Wang, Thomas J ; Reinius, Lovisa E ; Mulder, Hindrik LU orcid ; Melander, Olle LU orcid and Ridderstråle, Martin LU (2017) In International Journal of Endocrinology 2017.
Abstract

Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n = 83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine... (More)

Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n = 83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the ≥10% weight loss group with an associated change in BMI (R(2) = 0.16-0.22, p < 0.002), whereas the scores increased in the <10% weight loss group (p < 0.0004). Conclusions. Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
International Journal of Endocrinology
volume
2017
article number
6490473
publisher
Hindawi Limited
external identifiers
  • scopus:85018993935
  • wos:000399373700001
  • pmid:28484491
ISSN
1687-8337
DOI
10.1155/2017/6490473
project
The use of Genomics and Proteomics for the Detection and Prevention of Cardiometabolic Disease
language
English
LU publication?
yes
id
dc4635e8-5f2f-4837-8099-fc5c57004867
date added to LUP
2017-05-12 14:48:32
date last changed
2025-01-07 13:19:15
@article{dc4635e8-5f2f-4837-8099-fc5c57004867,
  abstract     = {{<p>Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n = 83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the ≥10% weight loss group with an associated change in BMI (R(2) = 0.16-0.22, p &lt; 0.002), whereas the scores increased in the &lt;10% weight loss group (p &lt; 0.0004). Conclusions. Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss.</p>}},
  author       = {{Geidenstam, Nina and Magnusson, Martin and Danielsson, Anders P H and Gerszten, Robert E and Wang, Thomas J and Reinius, Lovisa E and Mulder, Hindrik and Melander, Olle and Ridderstråle, Martin}},
  issn         = {{1687-8337}},
  keywords     = {{Journal Article}},
  language     = {{eng}},
  publisher    = {{Hindawi Limited}},
  series       = {{International Journal of Endocrinology}},
  title        = {{Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss}},
  url          = {{http://dx.doi.org/10.1155/2017/6490473}},
  doi          = {{10.1155/2017/6490473}},
  volume       = {{2017}},
  year         = {{2017}},
}