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Contrast enhanced magneto-motive ultrasound in lymph nodes-modelling and pre-clinical imaging using magnetic microbubbles

Sjostrand, Sandra LU ; Bacou, Marion ; Thomson, Adrian ; Kaczmarek, Katarzyna ; Evertsson, Maria LU ; Svensson, Ingrid LU ; Farrington, Susan M. ; Moug, Susan ; Jansson, Tomas LU and Moran, Carmel M. , et al. (2022) 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2022-July. p.194-197
Abstract

Despite advances in MRI, the detection and characterisation of lymph nodes in rectal cancer remains complex, especially when assessing the response to neo-adjuvant treatment. An alternative approach is functional imaging, previously shown to aid characterization of cancer tissues. We report proof-of-concept of the novel technique Contrast-Enhanced Magneto-Motive Ultrasound (CE-MMUS) to recover information relating to local perfusion and lymphatic drainage, and interrogate tissue mechanical properties through magnetically induced tissue deformations. The feasibility of the proposed application was explored using a combination of pre-clinical ultrasound imaging and finite element analysis. First, contrast enhanced ultrasound imaging on... (More)

Despite advances in MRI, the detection and characterisation of lymph nodes in rectal cancer remains complex, especially when assessing the response to neo-adjuvant treatment. An alternative approach is functional imaging, previously shown to aid characterization of cancer tissues. We report proof-of-concept of the novel technique Contrast-Enhanced Magneto-Motive Ultrasound (CE-MMUS) to recover information relating to local perfusion and lymphatic drainage, and interrogate tissue mechanical properties through magnetically induced tissue deformations. The feasibility of the proposed application was explored using a combination of pre-clinical ultrasound imaging and finite element analysis. First, contrast enhanced ultrasound imaging on one wild type mouse recorded lymphatic drainage of magnetic microbubbles after bolus injection. Second, preliminary CE-MMUS data were acquired as a proof of concept. Third, the magneto-mechanical interactions of a magnetic microbubble with an elastic solid were simulated using finite element software. Accumulation of magnetic microbubbles in the inguinal lymph node was verified using contrast enhanced ultrasound, with peak enhancement occurring 3.7 s post-injection. Preliminary CE-MMUS indicates the presence of magnetic contrast agent in the lymph node. The finite element analysis explores how the magnetic force is transferred to motion of the solid, which depends on elasticity and bubble radius, indicating an inverse relation with displacement. Combining magnetic microbubbles with MMUS could harness the advantages of both techniques, to provide perfusion information, robust lymph node delineation and characterisation based on mechanical properties. Clinical Relevance-Robust detection and characterisation of lymph nodes could be aided by visualising lymphatic drainage of magnetic microbubbles using contrast enhanced ultrasound imaging and magneto-motion, which is dependent on tissue mechanical properties.

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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
series title
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
volume
2022-July
pages
4 pages
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
conference name
44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
conference location
Glasgow, United Kingdom
conference dates
2022-07-11 - 2022-07-15
external identifiers
  • pmid:36086230
  • scopus:85138126679
ISSN
1557-170X
ISBN
9781728127828
DOI
10.1109/EMBC48229.2022.9871876
language
English
LU publication?
yes
additional info
Funding Information: This research was funded by CRUK-grant numbers A23333/24730, Program Award DRCPGM\100012 (S.M.F.), Kamprad Family Foundation, ref no 20150065, Swedish Research Council, ref no 2015-05118, and Olle Engkvist Foundation, ref no 196-0143. Funding Information: *Research supported by Cancer Research UK (A23333 / 24730). H Mulvana is with the Department of Biomedical Engineering at the University of Strathclyde, Glasgow, UK. (helen.mulvana@strath.ac.uk). Publisher Copyright: © 2022 IEEE.
id
dc92d24b-152d-4422-8be5-be7dd0c58dd0
date added to LUP
2022-12-29 13:26:58
date last changed
2024-11-01 13:18:04
@inproceedings{dc92d24b-152d-4422-8be5-be7dd0c58dd0,
  abstract     = {{<p>Despite advances in MRI, the detection and characterisation of lymph nodes in rectal cancer remains complex, especially when assessing the response to neo-adjuvant treatment. An alternative approach is functional imaging, previously shown to aid characterization of cancer tissues. We report proof-of-concept of the novel technique Contrast-Enhanced Magneto-Motive Ultrasound (CE-MMUS) to recover information relating to local perfusion and lymphatic drainage, and interrogate tissue mechanical properties through magnetically induced tissue deformations. The feasibility of the proposed application was explored using a combination of pre-clinical ultrasound imaging and finite element analysis. First, contrast enhanced ultrasound imaging on one wild type mouse recorded lymphatic drainage of magnetic microbubbles after bolus injection. Second, preliminary CE-MMUS data were acquired as a proof of concept. Third, the magneto-mechanical interactions of a magnetic microbubble with an elastic solid were simulated using finite element software. Accumulation of magnetic microbubbles in the inguinal lymph node was verified using contrast enhanced ultrasound, with peak enhancement occurring 3.7 s post-injection. Preliminary CE-MMUS indicates the presence of magnetic contrast agent in the lymph node. The finite element analysis explores how the magnetic force is transferred to motion of the solid, which depends on elasticity and bubble radius, indicating an inverse relation with displacement. Combining magnetic microbubbles with MMUS could harness the advantages of both techniques, to provide perfusion information, robust lymph node delineation and characterisation based on mechanical properties. Clinical Relevance-Robust detection and characterisation of lymph nodes could be aided by visualising lymphatic drainage of magnetic microbubbles using contrast enhanced ultrasound imaging and magneto-motion, which is dependent on tissue mechanical properties.</p>}},
  author       = {{Sjostrand, Sandra and Bacou, Marion and Thomson, Adrian and Kaczmarek, Katarzyna and Evertsson, Maria and Svensson, Ingrid and Farrington, Susan M. and Moug, Susan and Jansson, Tomas and Moran, Carmel M. and Mulvana, Helen}},
  booktitle    = {{44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022}},
  isbn         = {{9781728127828}},
  issn         = {{1557-170X}},
  language     = {{eng}},
  pages        = {{194--197}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  series       = {{Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS}},
  title        = {{Contrast enhanced magneto-motive ultrasound in lymph nodes-modelling and pre-clinical imaging using magnetic microbubbles}},
  url          = {{http://dx.doi.org/10.1109/EMBC48229.2022.9871876}},
  doi          = {{10.1109/EMBC48229.2022.9871876}},
  volume       = {{2022-July}},
  year         = {{2022}},
}