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Longer colonic transit time is associated with laxative and drug use, Lifestyle factors and symptoms of constipation

Bohlin, Johan; Dahlin, Erik; Dreja, Julia; Roth, Bodil LU ; Ekberg, Olle LU and Ohlsson, Bodil LU (2018) In Acta radiologica open 7(10).
Abstract
Background
Gastrointestinal symptoms and changes in colonic transit time (CTT) are common in the population.
Purpose
To evaluate consecutive patients who had been examined for CTT, along with completion of a diary about laxative and drug use, lifestyle factors, and gastrointestinal symptoms, to identify possible associations with longer or prolonged CTT.
Material and Methods
A total of 610 consecutive patients had undergone the radiopaque marker method with an abdominal X-ray for clinical purposes. The patients had completed a diary regarding medical treatment, lifestyle factors, stool habits, and their perceived constipation and abdominal pain during the examination period. The associations between CTT and laxative... (More)
Background
Gastrointestinal symptoms and changes in colonic transit time (CTT) are common in the population.
Purpose
To evaluate consecutive patients who had been examined for CTT, along with completion of a diary about laxative and drug use, lifestyle factors, and gastrointestinal symptoms, to identify possible associations with longer or prolonged CTT.
Material and Methods
A total of 610 consecutive patients had undergone the radiopaque marker method with an abdominal X-ray for clinical purposes. The patients had completed a diary regarding medical treatment, lifestyle factors, stool habits, and their perceived constipation and abdominal pain during the examination period. The associations between CTT and laxative use, lifestyle factors, stool habits, and symptoms were calculated by logistic regression.
Results
Women had longer CTT (2.5 [1.6–3.9] vs. 1.7 [1.1–3.0] days, P < 0.001), lower weekly stool frequency (6 [3–10] vs. 8 [5–12], P = 0.001), and perceived more constipation (P = 0.025) and abdominal pain (P = 0.001) than men. High coffee consumption (P = 0.045), bulk-forming (P = 0.007) and osmotic (P = 0.001) laxatives, and lower stool frequency, shaped stool, and perceived constipation (P for trend < 0.001) were associated with longer CTT. In total, 382 patients (63%) were treated with drugs affecting motility. In the 228 patients without drug treatment, longer CTT was associated with female sex and smoking, and lower frequency of symptoms and prolonged CTT were observed compared to patients using drugs. Tea, alcohol, and abdominal pain did not associate with CTT.
Conclusions
Female sex, coffee, smoking, drug use, infrequent stools, shaped stool, and perception of constipation are associated with longer or prolonged CTT. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta radiologica open
volume
7
issue
10
publisher
SAGE Publications Inc.
ISSN
2058-4601
DOI
10.1177/2058460118807232
language
English
LU publication?
yes
id
dcf4779f-c011-423c-93de-4be3650a6b6e
date added to LUP
2019-06-17 12:58:48
date last changed
2019-06-19 13:02:40
@article{dcf4779f-c011-423c-93de-4be3650a6b6e,
  abstract     = {Background<br>
Gastrointestinal symptoms and changes in colonic transit time (CTT) are common in the population.<br>
Purpose<br>
To evaluate consecutive patients who had been examined for CTT, along with completion of a diary about laxative and drug use, lifestyle factors, and gastrointestinal symptoms, to identify possible associations with longer or prolonged CTT.<br>
Material and Methods<br>
A total of 610 consecutive patients had undergone the radiopaque marker method with an abdominal X-ray for clinical purposes. The patients had completed a diary regarding medical treatment, lifestyle factors, stool habits, and their perceived constipation and abdominal pain during the examination period. The associations between CTT and laxative use, lifestyle factors, stool habits, and symptoms were calculated by logistic regression.<br>
Results<br>
Women had longer CTT (2.5 [1.6–3.9] vs. 1.7 [1.1–3.0] days, P &lt; 0.001), lower weekly stool frequency (6 [3–10] vs. 8 [5–12], P = 0.001), and perceived more constipation (P = 0.025) and abdominal pain (P = 0.001) than men. High coffee consumption (P = 0.045), bulk-forming (P = 0.007) and osmotic (P = 0.001) laxatives, and lower stool frequency, shaped stool, and perceived constipation (P for trend &lt; 0.001) were associated with longer CTT. In total, 382 patients (63%) were treated with drugs affecting motility. In the 228 patients without drug treatment, longer CTT was associated with female sex and smoking, and lower frequency of symptoms and prolonged CTT were observed compared to patients using drugs. Tea, alcohol, and abdominal pain did not associate with CTT.<br>
Conclusions<br>
Female sex, coffee, smoking, drug use, infrequent stools, shaped stool, and perception of constipation are associated with longer or prolonged CTT.},
  author       = {Bohlin, Johan and Dahlin, Erik and Dreja, Julia and Roth, Bodil and Ekberg, Olle and Ohlsson, Bodil},
  issn         = {2058-4601},
  language     = {eng},
  number       = {10},
  publisher    = {SAGE Publications Inc.},
  series       = {Acta radiologica open},
  title        = {Longer colonic transit time is associated with laxative and drug use, Lifestyle factors and symptoms of constipation},
  url          = {http://dx.doi.org/10.1177/2058460118807232},
  volume       = {7},
  year         = {2018},
}