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Severe intestinal dysbiosis is prevalent in primary Sjögren's syndrome and is associated with systemic disease activity.

Mandl, Thomas LU ; Marsal, Jan LU ; Olsson, Peter LU ; Ohlsson, Bodil LU and Andréasson, Kristofer LU (2017) In Arthritis Research & Therapy 19(1).
Abstract (Swedish)
BACKGROUND:

Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren's syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis.

METHODS:

Forty-two consecutive pSS patients and 35 age-matched and sex-matched control subjects were included in the study in an open clinic setting. Stool samples were analyzed for intestinal dysbiosis using a validated 16S rRNA-based microbiota test (GA-map™ Dysbiosis Test; Genetic Analysis, Oslo, Norway). Dysbiosis and severe dysbiosis were defined in accordance with the... (More)
BACKGROUND:

Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren's syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis.

METHODS:

Forty-two consecutive pSS patients and 35 age-matched and sex-matched control subjects were included in the study in an open clinic setting. Stool samples were analyzed for intestinal dysbiosis using a validated 16S rRNA-based microbiota test (GA-map™ Dysbiosis Test; Genetic Analysis, Oslo, Norway). Dysbiosis and severe dysbiosis were defined in accordance with the manufacturer's instructions. Patients were evaluated with regard to disease activity (European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease Activity Index (ESSDAI) and Clinical ESSDAI (ClinESSDAI)). In addition, patients were examined for laboratory and serological features of pSS as well as fecal calprotectin levels. Furthermore, patients were investigated regarding patient-reported outcomes for pSS (EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI)) and irritable bowel syndrome (IBS)-like symptoms according to the Rome III criteria.

RESULTS:

Severe dysbiosis was more prevalent in pSS patients in comparison to controls (21 vs 3%; p = 0.018). Subjects with pSS and severe dysbiosis had higher disease activity as evaluated by the ESSDAI total score (13 vs 5; p = 0.049) and the ClinESSDAI total score (12 vs 5; p = 0.049), lower levels of complement component 4 (0.11 vs 0.17 g/L; p = 0.004), as well as higher levels of fecal calprotectin (110 vs 33 μg/g; p = 0.001) compared to the other pSS patients. In contrast, severe dysbiosis among pSS patients was not associated with disease duration, IBS-like symptoms, or the ESSPRI total score.

CONCLUSIONS:

Severe intestinal dysbiosis is a prevalent finding in pSS and is associated both with clinical and laboratory markers of systemic disease activity as well as gastrointestinal inflammation. Further studies are warranted to elucidate a potential causative link between dysbiosis and pSS.
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Abstract
Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren’s syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis Research & Therapy
volume
19
issue
1
pages
7 pages
publisher
BioMed Central
external identifiers
  • pmid:29065905
ISSN
1478-6354
DOI
10.1186/s13075-017-1446-2
language
English
LU publication?
yes
id
eb5e0955-c28c-47b2-a1b2-a440b0e72d71
date added to LUP
2017-11-08 16:08:59
date last changed
2017-11-10 03:00:03
@article{eb5e0955-c28c-47b2-a1b2-a440b0e72d71,
  abstract     = {Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren’s syndrome (pSS). The aims of the current study were to study the intestinal microbial balance in pSS and to identify clinical features associated with dysbiosis.},
  articleno    = {237},
  author       = {Mandl, Thomas and Marsal, Jan and Olsson, Peter and Ohlsson, Bodil and Andréasson, Kristofer},
  issn         = {1478-6354},
  language     = {eng},
  month        = {10},
  number       = {1},
  pages        = {7},
  publisher    = {BioMed Central},
  series       = {Arthritis Research & Therapy},
  title        = {Severe intestinal dysbiosis is prevalent in primary Sjögren's syndrome and is associated with systemic disease activity.},
  url          = {http://dx.doi.org/10.1186/s13075-017-1446-2},
  volume       = {19},
  year         = {2017},
}