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Low expression of SHP-2 is associated with less favorable prostate cancer outcomes.

Tassidis, Helena LU ; Brokken, Leon LU ; Jirström, Karin LU orcid ; Bjartell, Anders LU ; Ulmert, David LU ; Härkönen, Pirkko LU and Gjörloff Wingren, Anette LU (2013) In Tumor Biology 34(2). p.637-642
Abstract
ABSTACT: Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor specimens from 122 patients with prostate cancer were analyzed using a tissue microarray. Our data demonstrate that all four prostate cancer cell lines express the SHP-2 protein. Additionally, low staining intensity and SHP-2 expression in the cytoplasm of cancer cells in prostate tumor specimens was inversely correlated with prostate volume (p = 0.041... (More)
ABSTACT: Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor specimens from 122 patients with prostate cancer were analyzed using a tissue microarray. Our data demonstrate that all four prostate cancer cell lines express the SHP-2 protein. Additionally, low staining intensity and SHP-2 expression in the cytoplasm of cancer cells in prostate tumor specimens was inversely correlated with prostate volume (p = 0.041 and p = 0.042, respectively) whereas nuclear staining was positively correlated with extracapsular extension (p = 0.039). In our post-prostatectomy specimens, we found that patients with low SHP-2 expression had less favorable outcomes with respect to biochemical recurrence and clinical progression (p = 0.005 and p = 0.018, respectively). The loss of cytoplasmic SHP-2 expression is associated with increased growth and prostatic cancer progression. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Tumor Biology
volume
34
issue
2
pages
637 - 642
publisher
Springer
external identifiers
  • wos:000316364500004
  • pmid:23192641
  • scopus:84877110354
  • pmid:23192641
ISSN
1423-0380
DOI
10.1007/s13277-012-0590-1
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Urological Cancers (013243420), Pathology, (Lund) (013030000), Tumour Biology, Malmö (013031300) Department affilation moved from v1000588 (Tumour Biology, Malmö) to v1000562 (Department of Translational Medicine) on 2016-01-18 14:39:29.
id
eca0c28f-7aa9-44c1-998a-c11ba91448b6 (old id 3218392)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23192641?dopt=Abstract
date added to LUP
2016-04-01 10:12:53
date last changed
2024-01-06 10:47:05
@article{eca0c28f-7aa9-44c1-998a-c11ba91448b6,
  abstract     = {{ABSTACT: Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor specimens from 122 patients with prostate cancer were analyzed using a tissue microarray. Our data demonstrate that all four prostate cancer cell lines express the SHP-2 protein. Additionally, low staining intensity and SHP-2 expression in the cytoplasm of cancer cells in prostate tumor specimens was inversely correlated with prostate volume (p = 0.041 and p = 0.042, respectively) whereas nuclear staining was positively correlated with extracapsular extension (p = 0.039). In our post-prostatectomy specimens, we found that patients with low SHP-2 expression had less favorable outcomes with respect to biochemical recurrence and clinical progression (p = 0.005 and p = 0.018, respectively). The loss of cytoplasmic SHP-2 expression is associated with increased growth and prostatic cancer progression.}},
  author       = {{Tassidis, Helena and Brokken, Leon and Jirström, Karin and Bjartell, Anders and Ulmert, David and Härkönen, Pirkko and Gjörloff Wingren, Anette}},
  issn         = {{1423-0380}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{637--642}},
  publisher    = {{Springer}},
  series       = {{Tumor Biology}},
  title        = {{Low expression of SHP-2 is associated with less favorable prostate cancer outcomes.}},
  url          = {{http://dx.doi.org/10.1007/s13277-012-0590-1}},
  doi          = {{10.1007/s13277-012-0590-1}},
  volume       = {{34}},
  year         = {{2013}},
}