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Development of dosimetric procedures for experimental ultra-high dose rate irradiation at a clinical linear accelerator

Konradsson, E. LU ; Petersson, K. LU ; Adrian, G. LU orcid ; Lempart, M. LU ; Blad, B. LU ; Ceberg, S. LU ; Knöös, T. LU orcid ; Bäck, S. Å.J. LU and Ceberg, C. LU orcid (2022) 11th International Conference on 3D Radiation Dosimetry, IC3DDose 2021 2167.
Abstract

As radiotherapy using ultra-high dose rates has gained new interest, the dosimetric challenges arising at these conditions needs to be addressed. Ionization chambers suffer from a large decrease in ion collection efficiency due to ion recombination, making on-line dosimetry difficult. In this work we present experimental setups and dosimetric procedures for FLASH irradiation of cells, zebrafish embryos and small animals using a 10 MeV electron beam at a modified clinical linear accelerator, and describe the dosimetric steps required to initiate clinical trials. The dosimetric equipment used for our pre-clinical experiments consisted of radiochromic film, thermoluminescent dosimeters, a Farmer-type ionization chamber and phantom material... (More)

As radiotherapy using ultra-high dose rates has gained new interest, the dosimetric challenges arising at these conditions needs to be addressed. Ionization chambers suffer from a large decrease in ion collection efficiency due to ion recombination, making on-line dosimetry difficult. In this work we present experimental setups and dosimetric procedures for FLASH irradiation of cells, zebrafish embryos and small animals using a 10 MeV electron beam at a modified clinical linear accelerator, and describe the dosimetric steps required to initiate clinical trials. The dosimetric equipment used for our pre-clinical experiments consisted of radiochromic film, thermoluminescent dosimeters, a Farmer-type ionization chamber and phantom material mimicking the experimental setup for irradiation. In preparation for small animal irradiation, dose profiles and depth dose curves were measured for all collimator sizes. The average dose rates were ≥620 Gy/s, ≥640 Gy/s and ≥400 Gy/s for cells, zebrafish embryos and small animals, respectively.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Journal of Physics: Conference Series
volume
2167
article number
012003
edition
1
publisher
IOP Publishing
conference name
11th International Conference on 3D Radiation Dosimetry, IC3DDose 2021
conference location
Quebec City, Virtual, Canada
conference dates
2021-06-15
external identifiers
  • scopus:85124685147
DOI
10.1088/1742-6596/2167/1/012003
language
English
LU publication?
yes
id
eda38b88-e68f-49ba-a48f-dcee7237cb39
date added to LUP
2022-04-13 12:41:36
date last changed
2023-05-08 16:26:21
@inproceedings{eda38b88-e68f-49ba-a48f-dcee7237cb39,
  abstract     = {{<p>As radiotherapy using ultra-high dose rates has gained new interest, the dosimetric challenges arising at these conditions needs to be addressed. Ionization chambers suffer from a large decrease in ion collection efficiency due to ion recombination, making on-line dosimetry difficult. In this work we present experimental setups and dosimetric procedures for FLASH irradiation of cells, zebrafish embryos and small animals using a 10 MeV electron beam at a modified clinical linear accelerator, and describe the dosimetric steps required to initiate clinical trials. The dosimetric equipment used for our pre-clinical experiments consisted of radiochromic film, thermoluminescent dosimeters, a Farmer-type ionization chamber and phantom material mimicking the experimental setup for irradiation. In preparation for small animal irradiation, dose profiles and depth dose curves were measured for all collimator sizes. The average dose rates were ≥620 Gy/s, ≥640 Gy/s and ≥400 Gy/s for cells, zebrafish embryos and small animals, respectively.</p>}},
  author       = {{Konradsson, E. and Petersson, K. and Adrian, G. and Lempart, M. and Blad, B. and Ceberg, S. and Knöös, T. and Bäck, S. Å.J. and Ceberg, C.}},
  booktitle    = {{Journal of Physics: Conference Series}},
  language     = {{eng}},
  publisher    = {{IOP Publishing}},
  title        = {{Development of dosimetric procedures for experimental ultra-high dose rate irradiation at a clinical linear accelerator}},
  url          = {{http://dx.doi.org/10.1088/1742-6596/2167/1/012003}},
  doi          = {{10.1088/1742-6596/2167/1/012003}},
  volume       = {{2167}},
  year         = {{2022}},
}