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Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition

Clasen, Joanna L. ; Mabunda, Rita ; Heath, Alicia K. ; Kaaks, Rudolf ; Katzke, Verena ; Schulze, Matthias B. ; Birukov, Anna ; Tagliabue, Giovanna ; Chiodini, Paolo and Tumino, Rosario , et al. (2023) In Cancer Medicine 12(14). p.15588-15600
Abstract

Background: Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology. Materials & Methods: We investigated associations of age at menarche and age at menopause, pregnancy-related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Results: During 15 years of follow-up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and... (More)

Background: Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology. Materials & Methods: We investigated associations of age at menarche and age at menopause, pregnancy-related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Results: During 15 years of follow-up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs. <20 years HR = 0.53, 95% CI 0.34, 0.82). Additionally, we identified a positive association for hysterectomy (HR = 1.43 95% CI 1.09, 1.86) and bilateral ovariectomy (HR = 1.67, 95% CI 1.13, 2.47), but not unilateral ovariectomy (HR = 0.99, 95% CI 0.61, 1.62) with RCC risk. No clear associations were found for age at menarche, age at menopause or exogenous hormone use. Conclusion: Our results suggest that parity and reproductive organ surgeries may play a role in RCC aetiology.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Medicine
volume
12
issue
14
pages
13 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:37269199
  • scopus:85161398621
ISSN
2045-7634
DOI
10.1002/cam4.6207
language
English
LU publication?
yes
id
efad6441-7602-4e76-8d1b-1c930ade0fa4
date added to LUP
2023-08-30 09:43:56
date last changed
2024-04-20 02:11:26
@article{efad6441-7602-4e76-8d1b-1c930ade0fa4,
  abstract     = {{<p>Background: Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology. Materials &amp; Methods: We investigated associations of age at menarche and age at menopause, pregnancy-related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Results: During 15 years of follow-up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs. &lt;20 years HR = 0.53, 95% CI 0.34, 0.82). Additionally, we identified a positive association for hysterectomy (HR = 1.43 95% CI 1.09, 1.86) and bilateral ovariectomy (HR = 1.67, 95% CI 1.13, 2.47), but not unilateral ovariectomy (HR = 0.99, 95% CI 0.61, 1.62) with RCC risk. No clear associations were found for age at menarche, age at menopause or exogenous hormone use. Conclusion: Our results suggest that parity and reproductive organ surgeries may play a role in RCC aetiology.</p>}},
  author       = {{Clasen, Joanna L. and Mabunda, Rita and Heath, Alicia K. and Kaaks, Rudolf and Katzke, Verena and Schulze, Matthias B. and Birukov, Anna and Tagliabue, Giovanna and Chiodini, Paolo and Tumino, Rosario and Milani, Lorenzo and Braaten, Tonje and Gram, Inger and Lukic, Marko and Luján-Barroso, Leila and Rodriguez-Barranco, Miguel and Chirlaque, María Dolores and Ardanaz, Eva and Amiano, Pilar and Manjer, Jonas and Huss, Linnea and Ljungberg, Börje and Travis, Ruth and Smith-Byrne, Karl and Gunter, Marc and Johansson, Matthias and Rinaldi, Sabina and Weiderpass, Elisabete and Riboli, Elio and Cross, Amanda J. and Muller, David C.}},
  issn         = {{2045-7634}},
  language     = {{eng}},
  number       = {{14}},
  pages        = {{15588--15600}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Cancer Medicine}},
  title        = {{Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition}},
  url          = {{http://dx.doi.org/10.1002/cam4.6207}},
  doi          = {{10.1002/cam4.6207}},
  volume       = {{12}},
  year         = {{2023}},
}