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Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Zamora-Ros, Raul; Cayssials, Valerie; Jenab, Mazda; Rothwell, Joseph A.; Fedirko, Veronika; Aleksandrova, Krasimira; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim and Boutron-Ruault, Marie Christine, et al. (2018) In European Journal of Epidemiology 33(11). p.1063-1075
Abstract

Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary... (More)

Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99–1.14) or in men (HRlog2 = 0.97, 95% CI 0.90–1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85–0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02–1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.

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keywords
Colorectal cancer, Diet, EPIC, Intake, Polyphenols, Prospective cohort
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European Journal of Epidemiology
volume
33
issue
11
pages
13 pages
publisher
Springer
external identifiers
  • scopus:85054798017
ISSN
0393-2990
DOI
10.1007/s10654-018-0408-6
language
English
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yes
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f72bb247-fa31-4110-be60-0df7c05ee871
date added to LUP
2018-10-31 15:02:32
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2019-02-20 11:34:13
@article{f72bb247-fa31-4110-be60-0df7c05ee871,
  abstract     = {<p>Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HR<sub>log2</sub> = 1.06, 95% CI 0.99–1.14) or in men (HR<sub>log2</sub> = 0.97, 95% CI 0.90–1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HR<sub>log2</sub> = 0.91, 95% CI 0.85–0.97) and positively associated with rectal cancer in women (HR<sub>log2</sub> = 1.10, 95% CI 1.02–1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.</p>},
  author       = {Zamora-Ros, Raul and Cayssials, Valerie and Jenab, Mazda and Rothwell, Joseph A. and Fedirko, Veronika and Aleksandrova, Krasimira and Tjønneland, Anne and Kyrø, Cecilie and Overvad, Kim and Boutron-Ruault, Marie Christine and Carbonnel, Franck and Mahamat-Saleh, Yahya and Kaaks, Rudolf and Kühn, Tilman and Boeing, Heiner and Trichopoulou, Antonia and Valanou, Elissavet and Vasilopoulou, Effie and Masala, Giovanna and Pala, Valeria and Panico, Salvatore and Tumino, Rosario and Ricceri, Fulvio and Weiderpass, Elisabete and Lukic, Marko and Sandanger, Torkjel M. and Lasheras, Cristina and Agudo, Antonio and Sánchez, Maria Jose and Amiano, Pilar and Navarro, Carmen and Ardanaz, Eva and Sonestedt, Emily and Ohlsson, Bodil and Nilsson, Lena Maria and Rutegård, Martin and Bueno-de-Mesquita, Bas and Peeters, Petra H. and Khaw, Kay Thee and Wareham, Nicholas J. and Bradbury, Kathryn and Freisling, Heinz and Romieu, Isabelle and Cross, Amanda J. and Vineis, Paolo and Scalbert, Augustin},
  issn         = {0393-2990},
  keyword      = {Colorectal cancer,Diet,EPIC,Intake,Polyphenols,Prospective cohort},
  language     = {eng},
  month        = {11},
  number       = {11},
  pages        = {1063--1075},
  publisher    = {Springer},
  series       = {European Journal of Epidemiology},
  title        = {Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort},
  url          = {http://dx.doi.org/10.1007/s10654-018-0408-6},
  volume       = {33},
  year         = {2018},
}