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Dietary intervention with an Okinawan-based Nordic diet in type 2 diabetes renders decreased interleukin-18 concentrations and increased neurofilament light concentrations in plasma

Nilholm, Clara LU ; Roth, Bodil LU ; Höglund, Peter LU ; Blennow, Kaj LU ; Englund, Elisabet LU ; Hansson, Oskar LU ; Zetterberg, Henrik LU and Ohlsson, Bodil LU (2018) In Nutrition Research 60. p.13-25
Abstract

Food may induce inflammation and favor development of metabolic diseases, which have been associated with increased inflammation and potential risk of cognitive impairment. It is customary to know whether food or disease promote inflammation. Our hypothesis was that Okinawan-based Nordic (O-BN) diet leads to decreased circulating concentrations of inflammatory and neural biomarkers. The objectives of this study were to examine the effects of the O-BN diet on inflammatory and neural responses. First, 2 different breakfasts; one standard and another O-BN-based, were given in random order to 19 healthy volunteers. Second, a 12-week O-BN-dietary intervention was performed in type 2 diabetes mellitus (T2DM), where the participants were... (More)

Food may induce inflammation and favor development of metabolic diseases, which have been associated with increased inflammation and potential risk of cognitive impairment. It is customary to know whether food or disease promote inflammation. Our hypothesis was that Okinawan-based Nordic (O-BN) diet leads to decreased circulating concentrations of inflammatory and neural biomarkers. The objectives of this study were to examine the effects of the O-BN diet on inflammatory and neural responses. First, 2 different breakfasts; one standard and another O-BN-based, were given in random order to 19 healthy volunteers. Second, a 12-week O-BN-dietary intervention was performed in type 2 diabetes mellitus (T2DM), where the participants were followed for another 16-weeks, with registration of anthropometry and metabolic parameters. Non-diabetic subjects served as controls at baseline. Plasma was analyzed for cytokines by a 10-plex Luminex assay and neurofilament light (NfL) by an ultrasensitive Single molecule assay. Cytokine levels decreased after a single breakfast intake, independent of diet composition. Cytokine levels were higher in T2DM than in controls. Anthropometric and metabolic parameters were improved by the dietary intervention. In parallel, cytokine levels were lowered, although only significantly for IL-18 (P =.001), with a tendency of significance for IL-12p70 (P =.07). Levels of IL-18 correlated with glucose, HbA1c and lipids, but not with body mass index, insulin or blood pressure. NfL levels increased during the intervention (P =.049). O-BN-based diet does not affect postprandial cytokine levels in health, whereas it renders decreased circulating IL-18 levels along with metabolic biomarkers in T2DM, with no beneficial effect on NfL.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cytokines, Glucose metabolism, IL-18, Inflammation, Neurofilament light, Okinawan-based Nordic diet, Type 2 diabetes
in
Nutrition Research
volume
60
pages
13 pages
publisher
Elsevier
external identifiers
  • scopus:85054247558
ISSN
0271-5317
DOI
10.1016/j.nutres.2018.08.002
language
English
LU publication?
yes
id
f8a318d2-2434-43ea-aa27-dbc1b796e175
date added to LUP
2018-10-26 14:41:36
date last changed
2019-04-05 13:02:35
@article{f8a318d2-2434-43ea-aa27-dbc1b796e175,
  abstract     = {<p>Food may induce inflammation and favor development of metabolic diseases, which have been associated with increased inflammation and potential risk of cognitive impairment. It is customary to know whether food or disease promote inflammation. Our hypothesis was that Okinawan-based Nordic (O-BN) diet leads to decreased circulating concentrations of inflammatory and neural biomarkers. The objectives of this study were to examine the effects of the O-BN diet on inflammatory and neural responses. First, 2 different breakfasts; one standard and another O-BN-based, were given in random order to 19 healthy volunteers. Second, a 12-week O-BN-dietary intervention was performed in type 2 diabetes mellitus (T2DM), where the participants were followed for another 16-weeks, with registration of anthropometry and metabolic parameters. Non-diabetic subjects served as controls at baseline. Plasma was analyzed for cytokines by a 10-plex Luminex assay and neurofilament light (NfL) by an ultrasensitive Single molecule assay. Cytokine levels decreased after a single breakfast intake, independent of diet composition. Cytokine levels were higher in T2DM than in controls. Anthropometric and metabolic parameters were improved by the dietary intervention. In parallel, cytokine levels were lowered, although only significantly for IL-18 (P =.001), with a tendency of significance for IL-12p70 (P =.07). Levels of IL-18 correlated with glucose, HbA1c and lipids, but not with body mass index, insulin or blood pressure. NfL levels increased during the intervention (P =.049). O-BN-based diet does not affect postprandial cytokine levels in health, whereas it renders decreased circulating IL-18 levels along with metabolic biomarkers in T2DM, with no beneficial effect on NfL.</p>},
  author       = {Nilholm, Clara and Roth, Bodil and Höglund, Peter and Blennow, Kaj and Englund, Elisabet and Hansson, Oskar and Zetterberg, Henrik and Ohlsson, Bodil},
  issn         = {0271-5317},
  keyword      = {Cytokines,Glucose metabolism,IL-18,Inflammation,Neurofilament light,Okinawan-based Nordic diet,Type 2 diabetes},
  language     = {eng},
  pages        = {13--25},
  publisher    = {Elsevier},
  series       = {Nutrition Research},
  title        = {Dietary intervention with an Okinawan-based Nordic diet in type 2 diabetes renders decreased interleukin-18 concentrations and increased neurofilament light concentrations in plasma},
  url          = {http://dx.doi.org/10.1016/j.nutres.2018.08.002},
  volume       = {60},
  year         = {2018},
}